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Pediatric Surgery International

Published in:

01-06-2018 | Original Article

Utility of pediatric female fertility preservation discussions following pelvic radiation

Authors: Rebecca M. Rentea, Ashwini S. Poola, Joy M. Fulbright, Shawn D. St. Peter, Sohail R. Shah

Published in: Pediatric Surgery International | Issue 6/2018

Abstract

Introduction

While many childhood cancers are curable with therapy, adverse consequences in fertility exist. We sought to assess the number of female patients with pelvic tumors receiving radiation therapy, and the proportion that undergo measures for fertility preservation (FP).

Methods

A total of 53 female patients treated with pelvic tumors from 2000 to 2016 were retrospectively identified.

Results

19 (34%) of these patients underwent pelvic radiation therapy (pXRT). Three of the patients received pXRT for palliative treatment. Of the 19 female patients receiving pXRT, six (31%) were prepubertal and 13 (68%) were postpubertal. Three patients (16%) had documentation of a discussion of FP measures prior to pXRT. One was prepubertal and the others were post-pubertal. Six patients (32%) were evaluated by endocrinology after radiation therapy, diagnosed with ovarian failure, and placed on hormone therapy. Current guidelines recommend discussion of FP in pre-and postpubertal patients with cancer. This 16-year retrospective review of female patients that underwent pXRT for pelvic tumors demonstrated < 17% of patients have documentation of a discussion of FP measures.

Conclusion

Female pediatric patients who underwent chemotherapy and pXRT suffer a high rate of premature ovarian failure, high morbidity and mortality as well as low rates of documented FP discussions. Based on these findings we have established a multi-disciplinary fertility preservation team available for consultation and a protocol for discussing and documenting the impact of pXRT, along with other treatments, on fertility.

Level of evidence

III.

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Title: Utility of pediatric female fertility preservation discussions following pelvic radiation
Authors: Rebecca M. Rentea
Ashwini S. Poola
Joy M. Fulbright
Shawn D. St. Peter
Sohail R. Shah
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 6/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4257-x

At a glance: The STEP trials

Springer Medicine

Utility of pediatric female fertility preservation discussions following pelvic radiation

Abstract

Introduction

Methods

Results

Conclusion

Level of evidence

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

Level of evidence

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