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Current Neurology and Neuroscience Reports

Published in:

01-01-2010

Utility of Functional MRI in Pediatric Neurology

Authors: Emily R. Freilich, William D. Gaillard

Published in: Current Neurology and Neuroscience Reports | Issue 1/2010

Abstract

Functional MRI (fMRI), a tool increasingly used to study cognitive function, is also an important tool for understanding not only normal development in healthy children, but also abnormal development, as seen in children with epilepsy, attention-deficit/hyperactivity disorder, and autism. Since its inception almost 15 years ago, fMRI has seen an explosion in its use and applications in the adult literature. However, only recently has it found a home in pediatric neurology. New adaptations in study design and technologic advances, especially the study of resting state functional connectivity as well as the use of passive task design in sedated children, have increased the utility of functional imaging in pediatrics to help us gain understanding into the developing brain at work. This article reviews the background of fMRI in pediatrics and highlights the most recent literature and clinical applications.

Cohen MS, Bookheimer SY: Localization of brain function using magnetic resonance imaging. Trends Neurosci 1994, 17:268–277.CrossRefPubMed

Medina LS, Berna B, Dunoyer C, et al.: Seizure disorders: functional MR imaging for diagnostic evaluation and surgical treatment—prospective study. Radiology 2005, 236:247–253.CrossRefPubMed

Gaillard WD, Grandin CB, Xu B: Developmental aspects of pediatric fMRI: considerations for image acquisition, analysis, and interpretation. Neuroimage 2001, 13:239–249.CrossRefPubMed

Muzik O, Chugani DC, Juhasz C, et al.: Statistical parametric mapping: assessment of application in children. Neuroimage 2000, 12(5):538–549.CrossRefPubMed

Wilke M, Schmithorst VJ, Holland SK: Assessment of spatial normalization of whole-brain magnetic resonance images in children. Hum Brain Map 2002, 17:48–60.CrossRef

Wilke M, Holland SK, Altaye M, Gaser C: Template-O-Matic: a toolbox for creating customized pediatric templates. Neuroimage 2008, 41(3):903–913.CrossRefPubMed

• Yerys BE, Jankowski KF, Shook D, et al.: The fMRI success rate of children and adolescents: typical development, epilepsy, attention deficit/hyperactivity disorder, and autism spectrum disorders. Hum Brain Mapp 2009, 30:3426–3435. This study compared the fMRI success rates of typically developing children with those of various patient populations, including patients with epilepsy, ADHD, and autism. Success rates were higher in the typically developing children and also improved with increasing age.CrossRefPubMed

Byars AW, Holland SK, Strawsburg RH, et al.: Practical aspects of conducting large-scale fMRI studies in children. J Child Neurol 2002, 17(12):885–890.CrossRefPubMed

Redcay E, Kennedy DP, Courchesne E: fMRI during natural sleep as a method to study brain function during early childhood. Neuroimage 2007, 38(4):696–707.CrossRefPubMed

10.

Biswal B, Yetkin FZ, Haughton VM, Hyde JS: Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 1995, 34:537–541.CrossRefPubMed

11.

Cohen AL, Fair DA, Dosenbach NUF, et al.: Defining functional areas in individual human brains using resting functional connectivity MRI. Neuroimage 2008, 41(1):45–57.CrossRefPubMed

12.

Fair DA, Schlaggar BL, Cohen AL, et al.: A method for using blocked and event-related fMRI data to study “resting state” functional connectivity. Neuroimage 2007, 35:396–405.CrossRefPubMed

13.

Lin W, Zhu Q, Gao W, et al.: Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain. Am J Neuroradiol 2008, 29:1883–1889.CrossRefPubMed

14.

Fransson P, Skiold B, Horsch S et al.: Resting-state networks in the infant brain. Proc Natl Acad Sci U S A 2007, 104(39):15531–15536.CrossRefPubMed

15.

Fransson P, Skiold B, Engstrom M, et al.: Spontaneous brain activity in the newborn brain during natural sleep—an fMRI study in infants born at full term. Pediatr Res 2009, 66(3):301–305.CrossRefPubMed

16.

Raichle ME, MacLeod AM, Snyder AZ, et al.: A default mode of brain function. Proc Natl Acad Sci U S A 2001, 98(2):676–682.CrossRefPubMed

17.

• Fair DA, Cohen AL, Dosenbach NUF, et al.: The maturing architecture of the brain’s default network. Proc Natl Acad Sci U S A 2008, 105(10):4028–4032. This study used rfc-MRI to demonstrate a developmental progression in the default network of the brain from school age to adulthood.CrossRefPubMed

18.

Gao W, Zhu H, Giovanello KS, et al.: Evidence on the emergence of the brain’s default network from 2-week-old to 2-year-old healthy pediatric subjects. Proc Natl Acad Sci U S A 2009, 106(16):6790–6795.CrossRefPubMed

19.

Fitzgerald DB, Cosgrove GR, Ronner S, et al.: Location of language in the cortex: a comparison between functional MR imaging and electrocortical stimulation. Am J Neuroradiol 1997, 18:1529–1539.PubMed

20.

Springer JA, Binder JF, Hammeke TA, et al.: Language dominance in neurologically normal and epilepsy subjects. A functional MRI study. Brain 1999, 122:2033–2045.

21.

Hertz-Pannier L, Gaillard WD, Mott SH, et al.: Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 1997, 48:1003–1012.PubMed

22.

Binder JR, Swanson SJ, Hammeke TA, et al.: Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 1996, 46:978–984.PubMed

23.

Bizzi A, Blasi V, Falini A, et al.: Presurgical functional MR imaging of language and motor functions: validation with intraoperative electrocortical mapping. Radiology 2008, 248(2):579–589.CrossRefPubMed

24.

Medina LS, Bernal B, Ruiz J: Role of functional MR in determining language dominance in epilepsy and nonepilepsy populations: a Bayesian analysis. Radiology 2007, 242(1):94–100.CrossRefPubMed

25.

Yuan W, Szaflarski JP, Schmithorst VJ, et al.: FMRI shows atypical language lateralization in pediatric epilepsy patients. Epilepsia 2006, 47(3):593–600.CrossRefPubMed

26.

Anderson DP, Harvey AS, Saling MM, et al.: fMRI lateralization of expressive language in children with cerebral lesions. Epilepsia 2006, 47(6):998–1008.CrossRefPubMed

27.

Gaillard WD, Berl MM, Moore EN, et al.: Atypical language in lesional and nonlesional complex partial epilepsy. Neurology 2007, 69:1761–1771.CrossRefPubMed

28.

DeTiege X, Connelly A, Liegeois F, et al.: Influence of motor functional magnetic resonance imaging on the surgical management of children and adolescents with symptomatic focal epilepsy. Neurosurgery 2009, 64(5):856–864.CrossRef

29.

Ogg RJ, Laningham FH, Clarke D, et al.: Passive range of motion functional magnetic resonance imaging localizing sensorimotor cortex in sedated children. J Neurosurg Pediatrics 2009, 4:317–322.CrossRef

30.

Shimony JS, Zhang D, Johnston JM: Resting-state spontaneous fluctuations in brain activity: a new paradigm for presurgical planning using fMRI. Acad Radiol 2009, 16(5):578–583.CrossRefPubMed

31.

Heep A, Scheef L, Jankowski J, et al.: Functional magnetic resonance imaging of the sensorimotor system in preterm infants. Pediatrics 2009, 123:294–300.CrossRefPubMed

32.

Bernal B, Altman NR: Speech delay in children: a functional MR imaging study. Radiology 2003, 229:651–658.CrossRefPubMed

33.

Redcay E, Courchesne E: Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year old children with autism spectrum disorder. Biol Psychiatry 2008, 64(7):589–598.CrossRefPubMed

34.

Knaus TA, Silver AM, Lindgren KA, et al.: fMRI activation during a language task in adolescents with ASD. J Int Neuropsychol Soc 2008, 14(6):967–979.CrossRefPubMed

35.

Kennedy DP, Courchesne E: The intrinsic functional organization of the brain is altered in autism. Neuroimage 2008, 39(4):1877–1885.CrossRefPubMed

36.

Jones TB, Bandettini PA, Kenworthy L, et al.: Sources of group differences in functional connectivity: an investigation applied to autism spectrum disorder. Neuroimage 2010, 49:401–414.CrossRefPubMed

37.

Karunanayaka PR, Holland SK, Schmithorst VJ, et al.: Age-related connectivity changes in fMRI data from children listening to stories. Neuroimage 2007, 34(1):349–360.CrossRefPubMed

38.

Ment LR, Peterson BS, Vohr B, et al.: Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task. J Pediatrics 2006, 149:490–498.CrossRef

39.

• Gozzo Y, Vohr B, Lacadie C, et al.: Alterations in neural connectivity in preterm children at school age. J Neuroimage 2009, 48:458–463. This is the first report of functional connectivity differences in the preterm and term brain at school age during a passive auditory listening task.CrossRef

40.

• Schafer RJ, Lacadie C, Vohr B, et al.: Alterations in functional connectivity for language in prematurely born adolescents. Brain 2009, 132:661–670. The authors examined functional connectivity differences subserving a semantic language task in the preterm and term brain at age 12 despite equal performance on the task, illustrating possible brain plasticity.CrossRefPubMed

41.

Marsh R, Zhu H, Schultz RT, et al.: A developmental fMRI study of self-regulatory control. Hum Brain Mapp 2006, 27(100):848–863.CrossRefPubMed

42.

Solanto MV, Schulz KP, Fan J, et al.: Event-related FMRI of inhibitory control in the predominantly inattentive and combined subtypes of ADHD. J Neuroimaging 2009, 19(3):205–212.CrossRefPubMed

43.

Epstein JN, DelBello MP, Adler CM, et al.: Differential patterns of brain activation over time in adolescents with and without attention deficit hyperactivity disorder (ADHD) during performance of a sustained attention task. Neuropediatrics 2009, 40:1–5.CrossRefPubMed

44.

• Peterson BS, Potenza MN, Wang Z, et al.: An FMRI study of the effects of psychostimulants on default-mode processing during stroop task performance in youths with ADHD. Am J Psychiatry 2009, 166(11):1286–1294. This study used fMRI to look at the effects of medication on task performance in patients with ADHD and to compare activation patterns during and after an inhibition task in the ADHD patients versus controls. The investigators showed that the stimulants appear not only to improve symptoms, but also to bring the default mode activation patterns closer to that of controls.CrossRefPubMed

45.

Rubia K, Halari R, Cubillo A, et al.: Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task. Neuropharmacology 2009, 57(7–8):640–652.CrossRefPubMed

46.

Cao X, Cao Q, Long X, et al.: Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder. Brain Res 2009, 1303:195–206.CrossRefPubMed

Title: Utility of Functional MRI in Pediatric Neurology
Authors: Emily R. Freilich
William D. Gaillard
Publication date: 01-01-2010
Publisher: Current Science Inc.
Published in: Current Neurology and Neuroscience Reports / Issue 1/2010
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-009-0077-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Utility of Functional MRI in Pediatric Neurology

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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