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Infectious Agents and Cancer
Published in: Infectious Agents and Cancer 1/2012

Open Access 01-12-2012 | Review

Using antimicrobial adjuvant therapy in cancer treatment: a review

Authors: Kenneth Alibek, Aliya Bekmurzayeva, Assel Mussabekova, Bolat Sultankulov

Published in: Infectious Agents and Cancer | Issue 1/2012

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Abstract

Recent clinical and pre-clinical data demonstrate that adjuvant antimicrobial therapy is beneficial in cancer treatment. There could be several reasons for this effect, which include treating cancer associated bacteria and viruses, prophylaxis of post-chemotherapy infections due to immunosuppression, and antiproliferative effect of certain antimicrobials. Targeting cancer associated viruses and bacteria with antimicrobial agents is currently used for gastric, cervical, hematopoietic, liver and brain cancer. However this treatment is effective only in combination with conventional therapies. Antimicrobials can also have a direct antiproliferative and cytotoxic effect, and can cause apoptosis. Moreover, some antimicrobials are known to be helpful in overcoming side effects of drugs commonly used in cancer treatment. Chemotherapy related bacteremia and neutropenia can be overcome by the appropriately timed use of antimicrobials. This review summarizes the data on the effects of antivirals and antibiotics on cancer treatment and describes their mechanisms.
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Metadata
Title
Using antimicrobial adjuvant therapy in cancer treatment: a review
Authors
Kenneth Alibek
Aliya Bekmurzayeva
Assel Mussabekova
Bolat Sultankulov
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Infectious Agents and Cancer / Issue 1/2012
Electronic ISSN: 1750-9378
DOI
https://doi.org/10.1186/1750-9378-7-33

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