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Journal of Hepato-Biliary-Pancreatic Sciences

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01-07-2009 | Original article

Usefulness of the CLIP scoring system for prediction of postoperative prognosis of patients with large hepatocellular carcinoma

Authors: Takehiro Noda, Yo Sasaki, Terumasa Yamada, Hidetoshi Eguchi, Masahiko Yano, Hiroaki Ohigashi, Osamu Ishikawa, Shingi Imaoka

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 4/2009

Abstract

Background

Some patients with large hepatocellular carcinoma (HCC > 10 cm in diameter) have favorable surgical outcome, but the selection criteria are controversial. The relationship among various staging systems [(AJCC/UICC TNM classification, Liver Cancer Study Group of Japan TNM classification, the Cancer of the Liver Italian Program (CLIP) scoring system and the Japan Integrated Staging scoring system] and postsurgical prognosis of patients with large HCC is unknown. The aim of this study was to identify the staging system with the best prognostic value for such patients.

Methods

The subjects of this retrospective study were 42 patients with large HCC. Various prognostic factors were assessed by multivariate analysis. The disease state was staged by the above four staging systems. The accuracy of prediction of 1-year, 3-year and 5-year mortality for each system was evaluated by the area under the receiver operating characteristic curve.

Results

Serum α-fetoprotein and curability were identified by multivariate analysis as the only significant prognostic factors. The discriminatory ability of the CLIP scoring system was superior to other systems. Patients with CLIP scores <2 had better prognosis (score = 0, 100% of 1-year survival rate; score = 1, 75%) than those with scores >2 (score = 2, 3 and 4; 50%, 46% and 33%, respectively).

Conclusions

The CLIP scoring system is the best for classifying patients with large HCC and prediction of their prognosis after surgery.

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Title: Usefulness of the CLIP scoring system for prediction of postoperative prognosis of patients with large hepatocellular carcinoma
Authors: Takehiro Noda
Yo Sasaki
Terumasa Yamada
Hidetoshi Eguchi
Masahiko Yano
Hiroaki Ohigashi
Osamu Ishikawa
Shingi Imaoka
Publication date: 01-07-2009
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 4/2009
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-009-0096-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Usefulness of the CLIP scoring system for prediction of postoperative prognosis of patients with large hepatocellular carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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