Skip to main content
Top
Published in: Oral and Maxillofacial Surgery 4/2009

01-12-2009 | Review

Usefulness of fine-needle aspiration in parotid diagnostics

Authors: Attilio Carlo Salgarelli, Paolo Capparè, Pierantonio Bellini, Marco Collini

Published in: Oral and Maxillofacial Surgery | Issue 4/2009

Login to get access

Abstract

Purpose

Fine needle aspiration (FNA) is a safe diagnostic technique that is widely employed for lesions of the head and neck. Among head and neck sites, the parotid gland is unique in the number, diversity, and peculiarity of its pathological processes. This complexity has prompted a great deal of discussion regarding the application of FNA to parotid masses, primarily focusing on the reliability of FNA as a diagnostic tool in guiding patient management.

Methods

This review presents an analysis of the usefulness of FNA in differential diagnosis of parotid pathologies.

Results

Recent studies have confirmed a wide range of accuracy rates for FNA evaluation of parotid masses, varying from 79% to 97%. These data cannot be uniformly anticipated across all diagnostic scenarios. FNA is notoriously unreliable in recognising the malignant nature of parotid carcinoma providing its precise classification and establishing its grade. A few malignant neoplasms are particularly prone to diagnostic error: acinic cell carcinoma is frequently interpreted as benign, and low-grade lymphomas are often discounted as inflammatory processes.

Conclusions

FNA cytology is useful in avoiding surgery (inflammatory lesions) or limiting surgical procedures (benign tumours). For planning the extent of surgery of malignant parotid tumours, the histological subtype and/or grade should be determined; therefore, a histological diagnosis by frozen section analysis is required. Moreover, reliance on FNA findings at the expense of clinical, radiographic, and intraoperative findings is unwarranted. Regardless of whether FNA is used routinely or selectively in patients with parotid masses, the findings should contribute to, and not replace, the overall diagnostic impression.
Literature
1.
go back to reference Megerian CA, Maniglia AJ (1994) Parotidectomy: a ten-year experience with fine needle aspiration and frozen section biopsy correlation. Ear Nose Throat J 73:377–380PubMed Megerian CA, Maniglia AJ (1994) Parotidectomy: a ten-year experience with fine needle aspiration and frozen section biopsy correlation. Ear Nose Throat J 73:377–380PubMed
2.
go back to reference Stewart CJ, MacKenzie K, McGarry GW, Mowat A (2000) Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol 22:139–146CrossRefPubMed Stewart CJ, MacKenzie K, McGarry GW, Mowat A (2000) Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol 22:139–146CrossRefPubMed
3.
go back to reference Chan MK, McGuire LJ, King W et al (1992) Cytodiagnosis of 112 salivary gland lesions. Correlation with histologic and frozen section diagnosis. Acta Cytol 36:353–363PubMed Chan MK, McGuire LJ, King W et al (1992) Cytodiagnosis of 112 salivary gland lesions. Correlation with histologic and frozen section diagnosis. Acta Cytol 36:353–363PubMed
4.
go back to reference Orell SR (1995) Diagnostic difficulties in the interpretation of fine needle aspirates of salivary gland lesions: the problem revisited. Cytopathology 6:285–300CrossRefPubMed Orell SR (1995) Diagnostic difficulties in the interpretation of fine needle aspirates of salivary gland lesions: the problem revisited. Cytopathology 6:285–300CrossRefPubMed
5.
go back to reference Zbären P, Guélat D, Loosli H, Stauffer E (2008) Parotid tumors: fine-needle aspiration and/or frozen section. Otolaryngol Head Neck Surg 139:811–815CrossRefPubMed Zbären P, Guélat D, Loosli H, Stauffer E (2008) Parotid tumors: fine-needle aspiration and/or frozen section. Otolaryngol Head Neck Surg 139:811–815CrossRefPubMed
6.
go back to reference Guntinas-Lichius O, Klussmann JP, Wittekindt C et al (2006) Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope 116:534–540CrossRefPubMed Guntinas-Lichius O, Klussmann JP, Wittekindt C et al (2006) Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope 116:534–540CrossRefPubMed
7.
go back to reference McGurk M, Thomas BL, Renehan AG (2003) Extracapsular dissection for clinically benign parotid lumps: reduced morbidity without oncological compromise. Br J Cancer 89:1610–1613CrossRefPubMed McGurk M, Thomas BL, Renehan AG (2003) Extracapsular dissection for clinically benign parotid lumps: reduced morbidity without oncological compromise. Br J Cancer 89:1610–1613CrossRefPubMed
8.
go back to reference Witt RL (2002) The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope 112:2141–2154CrossRefPubMed Witt RL (2002) The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope 112:2141–2154CrossRefPubMed
9.
go back to reference Hussain A, Murray DP (2005) Preservation of the superficial lobe for deep-lobe parotid tumors: a better aesthetic outcome. Ear Nose Throat J 84:518–524PubMed Hussain A, Murray DP (2005) Preservation of the superficial lobe for deep-lobe parotid tumors: a better aesthetic outcome. Ear Nose Throat J 84:518–524PubMed
10.
go back to reference Zbären P, Schüpbach J, Stauffer E et al (2003) Carcinoma of the parotid gland. Am J Surg 186:57–62CrossRefPubMed Zbären P, Schüpbach J, Stauffer E et al (2003) Carcinoma of the parotid gland. Am J Surg 186:57–62CrossRefPubMed
11.
go back to reference Wong DS (2001) Signs and symptoms of malignant parotid tumours: an objective assessment. J R Coll Surg Edinb 46:91–95PubMed Wong DS (2001) Signs and symptoms of malignant parotid tumours: an objective assessment. J R Coll Surg Edinb 46:91–95PubMed
12.
go back to reference Zbären P, Schupbach J, Nuyens M et al (2005) Elective neck dissection versus observation in primary parotid carcinoma. Otolaryngol Head Neck Surg 132:387–391CrossRefPubMed Zbären P, Schupbach J, Nuyens M et al (2005) Elective neck dissection versus observation in primary parotid carcinoma. Otolaryngol Head Neck Surg 132:387–391CrossRefPubMed
13.
go back to reference Stennert E, Kisner D, Jungehuelsing M et al (2003) High incidence of lymph node metastasis in major salivary gland cancer. Arch Otolaryngol Head Neck Surg 129:720–723CrossRefPubMed Stennert E, Kisner D, Jungehuelsing M et al (2003) High incidence of lymph node metastasis in major salivary gland cancer. Arch Otolaryngol Head Neck Surg 129:720–723CrossRefPubMed
14.
go back to reference Armstrong JG, Harrison LB, Thaler HT et al (1992) The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 69:615–619CrossRefPubMed Armstrong JG, Harrison LB, Thaler HT et al (1992) The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 69:615–619CrossRefPubMed
15.
go back to reference Medina JE (1998) Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am 31:815–822CrossRefPubMed Medina JE (1998) Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am 31:815–822CrossRefPubMed
16.
go back to reference Zbären P, Nuyens M, Loosly H et al (2004) Diagnostic accuracy of fine-needle aspiration cytology and frozen section in primary parotid carcinoma. Cancer 100:1876–1883CrossRefPubMed Zbären P, Nuyens M, Loosly H et al (2004) Diagnostic accuracy of fine-needle aspiration cytology and frozen section in primary parotid carcinoma. Cancer 100:1876–1883CrossRefPubMed
17.
go back to reference Carvhalo MB, Soares JMA, Rapoport A et al (1999) Perioperative frozen section examination in parotid gland tumors. Sao Paulo Med J 117:233–237 Carvhalo MB, Soares JMA, Rapoport A et al (1999) Perioperative frozen section examination in parotid gland tumors. Sao Paulo Med J 117:233–237
18.
go back to reference Wong DS (2002) Frozen section during parotid surgery revisited: efficacy of its applications and changing trend of indications. Head Neck 24:191–197CrossRefPubMed Wong DS (2002) Frozen section during parotid surgery revisited: efficacy of its applications and changing trend of indications. Head Neck 24:191–197CrossRefPubMed
19.
go back to reference Layfield LJ, Tan P, Glasgow BJ (1987) Fine-needle aspiration of salivary gland lesions. Comparison with frozen sections and histologic findings. Arch Pathol Lab Med 111:346–353PubMed Layfield LJ, Tan P, Glasgow BJ (1987) Fine-needle aspiration of salivary gland lesions. Comparison with frozen sections and histologic findings. Arch Pathol Lab Med 111:346–353PubMed
20.
go back to reference Seethala RR, LiVolsi VA, Baloch ZW (2005) Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland. Head Neck 27:217–223CrossRefPubMed Seethala RR, LiVolsi VA, Baloch ZW (2005) Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland. Head Neck 27:217–223CrossRefPubMed
21.
go back to reference Klijanienko J, El-Naggar AK, Vielh P (1999) Fine-needle sampling findings in 26 carcinoma ex pleomorphic adenomas: diagnostic pitfalls and clinical considerations. Diagn Cytopathol 21:163–166CrossRefPubMed Klijanienko J, El-Naggar AK, Vielh P (1999) Fine-needle sampling findings in 26 carcinoma ex pleomorphic adenomas: diagnostic pitfalls and clinical considerations. Diagn Cytopathol 21:163–166CrossRefPubMed
22.
go back to reference Zbären P, Zbären S, Caversaccio MD et al (2008) Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg 138:601–605CrossRefPubMed Zbären P, Zbären S, Caversaccio MD et al (2008) Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg 138:601–605CrossRefPubMed
23.
go back to reference Zurrida S, Alasio L, Tradati N et al (1993) Fine-needle aspiration of parotid masses. Cancer 72:2306–2311CrossRefPubMed Zurrida S, Alasio L, Tradati N et al (1993) Fine-needle aspiration of parotid masses. Cancer 72:2306–2311CrossRefPubMed
24.
go back to reference Batsakis JG, Sueige N, el-Naggar AK (1992) Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol 101:185–188PubMed Batsakis JG, Sueige N, el-Naggar AK (1992) Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol 101:185–188PubMed
25.
go back to reference Owen EERTC, Banerjee AK, Prichard AJN, Hudson EA, Kark AE (1989) Role of fine-needle aspiration cytology and computed tomography in the diagnosis of parotid swellings. Br J Surg 76:1273–1274CrossRefPubMed Owen EERTC, Banerjee AK, Prichard AJN, Hudson EA, Kark AE (1989) Role of fine-needle aspiration cytology and computed tomography in the diagnosis of parotid swellings. Br J Surg 76:1273–1274CrossRefPubMed
26.
go back to reference Cramer H, Layfield L, Lampe H (1993) Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol 102:483–485PubMed Cramer H, Layfield L, Lampe H (1993) Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol 102:483–485PubMed
27.
go back to reference Spiro RH (1991) Diagnosis and pitfalls in the treatment of parotid tumors. Semin Surg Oncol 7:20–24CrossRefPubMed Spiro RH (1991) Diagnosis and pitfalls in the treatment of parotid tumors. Semin Surg Oncol 7:20–24CrossRefPubMed
28.
go back to reference Alphs HH, Eisele DW, Westra WH (2006) The role of fine needle aspiration in the evaluation of parotid masses. Curr Opin Otolaryngol Head Neck Surg 14:62–66CrossRefPubMed Alphs HH, Eisele DW, Westra WH (2006) The role of fine needle aspiration in the evaluation of parotid masses. Curr Opin Otolaryngol Head Neck Surg 14:62–66CrossRefPubMed
29.
30.
go back to reference Dudgeon LS, Patrick CV (1927) A new method for the rapid mircroscopical diagnosis of tumours. Br J Surg 15:250–261CrossRef Dudgeon LS, Patrick CV (1927) A new method for the rapid mircroscopical diagnosis of tumours. Br J Surg 15:250–261CrossRef
31.
go back to reference Mavec P, Eneroth CM, Franzen S, Moberger G, Zajicek J (1964) Aspiration biopsy of salivary gland tumors. Acta Otolaryngo (Stockh) 58:471–484CrossRef Mavec P, Eneroth CM, Franzen S, Moberger G, Zajicek J (1964) Aspiration biopsy of salivary gland tumors. Acta Otolaryngo (Stockh) 58:471–484CrossRef
32.
go back to reference Bonneau H, Sommer D (1959) L’orientation du diagnositc des tumeurs salivaires par la ponction a l’aiguille fine. Pathol Biol 7:786–791 Bonneau H, Sommer D (1959) L’orientation du diagnositc des tumeurs salivaires par la ponction a l’aiguille fine. Pathol Biol 7:786–791
33.
34.
go back to reference Marx RE, Stern D (2004) Oral and maxillofacial pathology: a rationale for diagnosis and treatment. Quintessence Pub, Chicago, IL Marx RE, Stern D (2004) Oral and maxillofacial pathology: a rationale for diagnosis and treatment. Quintessence Pub, Chicago, IL
35.
go back to reference Qizilbash AH, Sianos J, Young JE, Archibald SD (1985) Fine needle aspiration biopsy cytology of major salivary glands. Acta Cytol 29:503–512PubMed Qizilbash AH, Sianos J, Young JE, Archibald SD (1985) Fine needle aspiration biopsy cytology of major salivary glands. Acta Cytol 29:503–512PubMed
36.
go back to reference Eveson JW, Auclair P, Gnepp DR, El-Naggar AK (2005) Tumours of the salivary glands. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon, pp 209–282 Eveson JW, Auclair P, Gnepp DR, El-Naggar AK (2005) Tumours of the salivary glands. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon, pp 209–282
37.
go back to reference Al-Khafaji BM, Nestok BR, Katz RL (1998) Fine-needle aspiration of 154 parotid masses with histologic correlation. Cancer 84:153–159CrossRefPubMed Al-Khafaji BM, Nestok BR, Katz RL (1998) Fine-needle aspiration of 154 parotid masses with histologic correlation. Cancer 84:153–159CrossRefPubMed
38.
go back to reference Cristallini EG, Ascani S, Farabi R et al (1997) Fine-needle aspiration biopsy of salivary gland, 1985–1995. Acta Cytol 41:1421–1425PubMed Cristallini EG, Ascani S, Farabi R et al (1997) Fine-needle aspiration biopsy of salivary gland, 1985–1995. Acta Cytol 41:1421–1425PubMed
39.
go back to reference Smith Frable MA, Frable WJ (1991) Fine-needle aspiration biopsy of salivary glands. Laryngoscope 101:245–249 Smith Frable MA, Frable WJ (1991) Fine-needle aspiration biopsy of salivary glands. Laryngoscope 101:245–249
40.
go back to reference Filopoulos E, Angeli S, Daskalopoulou D, Kelessis N, Vassilopoulos P (1998) Pre-operative evaluation of parotid tumours by fine needle biopsy. Eur J Surg Oncol 24:180–183CrossRefPubMed Filopoulos E, Angeli S, Daskalopoulou D, Kelessis N, Vassilopoulos P (1998) Pre-operative evaluation of parotid tumours by fine needle biopsy. Eur J Surg Oncol 24:180–183CrossRefPubMed
41.
go back to reference Das DK, Petkar MA, Al Mane NM et al (2004) Role of fine needle aspiration cytology in the diagnosis of swellings in the salivary gland regions: a study of 712 cases. Med Princ Pract 13:95–106CrossRefPubMed Das DK, Petkar MA, Al Mane NM et al (2004) Role of fine needle aspiration cytology in the diagnosis of swellings in the salivary gland regions: a study of 712 cases. Med Princ Pract 13:95–106CrossRefPubMed
42.
go back to reference Bajaj Y, Singh S, Cozens N, Sharp J (2005) Critical clinical appraisal of the role of ultrasound guided fine needle aspiration cytology in the management of parotid tumours. J Laryngol Otol 19:289–292 Bajaj Y, Singh S, Cozens N, Sharp J (2005) Critical clinical appraisal of the role of ultrasound guided fine needle aspiration cytology in the management of parotid tumours. J Laryngol Otol 19:289–292
43.
go back to reference Sergi B, Contucci AM, Corina L, Paludetti G (2004) Value of fine-needle aspiration cytology of parotid gland masses. Laryngoscope 114:789–792CrossRefPubMed Sergi B, Contucci AM, Corina L, Paludetti G (2004) Value of fine-needle aspiration cytology of parotid gland masses. Laryngoscope 114:789–792CrossRefPubMed
44.
go back to reference Balakrishnan K, Castling B, McMahon J et al (2005) Fine needle aspiration cytology in the management of a parotid mass: a two centre retrospective study. Surgeon 3:67–72PubMedCrossRef Balakrishnan K, Castling B, McMahon J et al (2005) Fine needle aspiration cytology in the management of a parotid mass: a two centre retrospective study. Surgeon 3:67–72PubMedCrossRef
45.
go back to reference Hughes JH, Volk EE, Wilbur DC (2005) Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 129:26–31PubMed Hughes JH, Volk EE, Wilbur DC (2005) Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 129:26–31PubMed
46.
47.
go back to reference Nanson EM (1966) The surgery of the deep lobe of the parotid salivary gland. Surg Gynecol Obstet 122:811–816PubMed Nanson EM (1966) The surgery of the deep lobe of the parotid salivary gland. Surg Gynecol Obstet 122:811–816PubMed
48.
go back to reference Awan MS, Ahmad Z (2004) Diagnostic value of fine needle aspiration cytology in parotid tumors. J Pak Med Assoc 54:617–619PubMed Awan MS, Ahmad Z (2004) Diagnostic value of fine needle aspiration cytology in parotid tumors. J Pak Med Assoc 54:617–619PubMed
49.
go back to reference Riley N, Allison R, Stevenson S (2005) Fine-needle aspiration cytology in parotid masses: our experience in Canterbury. New Zealand ANZ J Surg 75:144–146CrossRef Riley N, Allison R, Stevenson S (2005) Fine-needle aspiration cytology in parotid masses: our experience in Canterbury. New Zealand ANZ J Surg 75:144–146CrossRef
50.
go back to reference Kim YH, Jeong WJ, Jung KY et al (2005) Diagnosis of major salivary gland tuberculosis: experience of eight cases and review of the literature. Acta Otolaryngol 125:1318–1322CrossRefPubMed Kim YH, Jeong WJ, Jung KY et al (2005) Diagnosis of major salivary gland tuberculosis: experience of eight cases and review of the literature. Acta Otolaryngol 125:1318–1322CrossRefPubMed
51.
go back to reference Cohen EG, Patel SG, Lin O et al (2004) Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population. Arch Otolaryngol Head Neck Surg 130:773–778CrossRefPubMed Cohen EG, Patel SG, Lin O et al (2004) Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population. Arch Otolaryngol Head Neck Surg 130:773–778CrossRefPubMed
Metadata
Title
Usefulness of fine-needle aspiration in parotid diagnostics
Authors
Attilio Carlo Salgarelli
Paolo Capparè
Pierantonio Bellini
Marco Collini
Publication date
01-12-2009
Publisher
Springer-Verlag
Published in
Oral and Maxillofacial Surgery / Issue 4/2009
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-009-0182-4

Other articles of this Issue 4/2009

Oral and Maxillofacial Surgery 4/2009 Go to the issue