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Published in: International Journal of Clinical Oncology 3/2014

01-06-2014 | Original Article

Usefulness of CT-lymphography in sentinel lymph node navigation

Authors: Masato Yasuta, Suguru Sato, Tomokazu Ishida, Takahiro Kiyohara

Published in: International Journal of Clinical Oncology | Issue 3/2014

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Abstract

Background

There are many methods for sentinel lymph node (SLN) navigation. The methods using radioisotopes and blue dyes are performed mainly for the identification of SLN. Our current method for SLN biopsy is a combination of three techniques with 99mTc-phytate, patent blue V dye, and preoperative CT-lymphography (CTLG).

Patients and methods

Iomeprol (Iomeron®) as a water-soluble contrast agent is diluted twofold with 1 % lidocaine and intradermally injected into a few sites (2–5 ml at each site) around the tumor. After the injection, CT imaging is performed using a 64-row MDCT system (Siemens SOMATOM Definition AS+). We performed CTLG in 34 patients (16 men, 18 women) between September 2008 and March 2013.

Results

CTLG clearly visualized the SLN and the lymphatic drainage in 21 out of 34 patients.

Conclusions

We can detect the SLN and lymphatic flow near to tumors without shine-through effect, especially in the head and neck regions. It is thought that CTLG may be useful to determine the range of lymph node dissection.
Literature
1.
go back to reference Hashimoto M, Taguchi M, Suzuki T et al (2004) A study of the actual state and usefulness of sentinel node biopsy for malignant melanoma (in Japanese). Jpn J Dermatol 114:1655–1661 Hashimoto M, Taguchi M, Suzuki T et al (2004) A study of the actual state and usefulness of sentinel node biopsy for malignant melanoma (in Japanese). Jpn J Dermatol 114:1655–1661
2.
go back to reference Asagoe K, Yamasaki O, Otsuka M et al (2006) Sentinel node biopsies for malignant melanoma performed at Okayama University Medical School (in Japanese). Skin Cancer (Japan) 21:151–157CrossRef Asagoe K, Yamasaki O, Otsuka M et al (2006) Sentinel node biopsies for malignant melanoma performed at Okayama University Medical School (in Japanese). Skin Cancer (Japan) 21:151–157CrossRef
3.
go back to reference Yoshida H, Nobeyama Y, Matsuo K et al (2009) A summary of sentinel node biopsy in patients with cutaneous malignant melanoma using the combination of blue dye and radiocolloid (in Japanese). Jpn J Dermatol 119:1993–2001 Yoshida H, Nobeyama Y, Matsuo K et al (2009) A summary of sentinel node biopsy in patients with cutaneous malignant melanoma using the combination of blue dye and radiocolloid (in Japanese). Jpn J Dermatol 119:1993–2001
4.
go back to reference Yanagisawa K, Takada T, Hida T et al (2011) Analysis of 44 patients with malignant melanoma on whom sentinel lymph node biopsy was performed using the technique of blue dye and radioisotope (in Japanese). Skin Cancer (Japan) 26:85–88 Yanagisawa K, Takada T, Hida T et al (2011) Analysis of 44 patients with malignant melanoma on whom sentinel lymph node biopsy was performed using the technique of blue dye and radioisotope (in Japanese). Skin Cancer (Japan) 26:85–88
5.
go back to reference Eberbach MA, Wahl RL, Argenta LC et al (1987) Utility of lymphoscintigraphy in directing surgical therapy for melanomas of the head, neck, and upper thorax. Surgery 102:433–442PubMed Eberbach MA, Wahl RL, Argenta LC et al (1987) Utility of lymphoscintigraphy in directing surgical therapy for melanomas of the head, neck, and upper thorax. Surgery 102:433–442PubMed
6.
go back to reference Jimenez RE, Panageas K, Busam KJ et al (2005) Prognostic implications of multiple lymphatic basin drainage in patients with truncal melanoma. J Clin Oncol 23:518–524PubMedCrossRef Jimenez RE, Panageas K, Busam KJ et al (2005) Prognostic implications of multiple lymphatic basin drainage in patients with truncal melanoma. J Clin Oncol 23:518–524PubMedCrossRef
7.
go back to reference Tangoku A, Nagao T, Kira M et al (2009) Sentinel node navigation endoscopic surgery using 3D CT lymphography and real time virtual sonography (in Japanese). Jpn J Breast Cancer 24:85–93 Tangoku A, Nagao T, Kira M et al (2009) Sentinel node navigation endoscopic surgery using 3D CT lymphography and real time virtual sonography (in Japanese). Jpn J Breast Cancer 24:85–93
8.
go back to reference Saito M, Nishiyama H, Oda Y et al (2012) The lingual lymph node identified as a sentinel node on CT lymphography in a patient with cN0 squamous cell carcinoma of the tongue. Dentomaxillofac Radiol 41:254–258PubMedCentralPubMedCrossRef Saito M, Nishiyama H, Oda Y et al (2012) The lingual lymph node identified as a sentinel node on CT lymphography in a patient with cN0 squamous cell carcinoma of the tongue. Dentomaxillofac Radiol 41:254–258PubMedCentralPubMedCrossRef
9.
10.
go back to reference Yuasa Y, Seike J, Yoshida T et al (2012) Sentinel lymph node biopsy using intraoperative indocyanine green fluorescence imaging navigated with preoperative CT lymphography for superficial esophageal cancer. Ann Surg Oncol 19:486–493PubMedCrossRef Yuasa Y, Seike J, Yoshida T et al (2012) Sentinel lymph node biopsy using intraoperative indocyanine green fluorescence imaging navigated with preoperative CT lymphography for superficial esophageal cancer. Ann Surg Oncol 19:486–493PubMedCrossRef
11.
go back to reference Yasuta M, Sato S, Isida T et al (2012) Sentinel lymph node navigation using ST-lymphography (in Japanese). Skin Cancer (Japan) 27:171–178 Yasuta M, Sato S, Isida T et al (2012) Sentinel lymph node navigation using ST-lymphography (in Japanese). Skin Cancer (Japan) 27:171–178
12.
go back to reference Tangoku A, Seike J, Nakano K et al (2007) Current status of sentinel lymph node navigation surgery in breast and gastrointestinal tract. J Med Invest 54:1–18PubMedCrossRef Tangoku A, Seike J, Nakano K et al (2007) Current status of sentinel lymph node navigation surgery in breast and gastrointestinal tract. J Med Invest 54:1–18PubMedCrossRef
13.
go back to reference Minohata J, Tatsumi K, Yoshida A et al (2009) Sentinel lymph node biopsy using CT-lymphography with ICG fluorescence navigation in breast cancer (in Japanese). Jpn J Breast Cancer 24:183–188 Minohata J, Tatsumi K, Yoshida A et al (2009) Sentinel lymph node biopsy using CT-lymphography with ICG fluorescence navigation in breast cancer (in Japanese). Jpn J Breast Cancer 24:183–188
Metadata
Title
Usefulness of CT-lymphography in sentinel lymph node navigation
Authors
Masato Yasuta
Suguru Sato
Tomokazu Ishida
Takahiro Kiyohara
Publication date
01-06-2014
Publisher
Springer Japan
Published in
International Journal of Clinical Oncology / Issue 3/2014
Print ISSN: 1341-9625
Electronic ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-013-0582-1

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