Published in:
01-09-2013 | Interesting Image
Usefulness of 18F-FDG-PET/CT in Evaluating a Brainstem Glioma in an Adult Patient with Neurofibromatosis Type 1
Published in: Nuclear Medicine and Molecular Imaging | Issue 3/2013
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We describe a case of a brainstem glioma (BSG) occurred in an adult patient with neurofibromatosis type 1 (NF1) and evaluated by Flourine-18-Fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT). A 32-year-old male patient with NF1 underwent brain magnetic resonance imaging (MRI) for the onset of diplopia, facial paresis and cerebellar signs and symptoms. MRI showed a brainstem lesion compatible with BSG. Biopsy was not performed. 18F-FDG-PET/CT demonstrated intense 18F-FDG uptake in the brainstem lesion, suggesting an aggressive neoplasm. The patient was referred to radiotherapy but he developed rapid disease progression. In this case, 18F-FDG-PET/CT provided useful information about this rare NF1-associated tumor (Figs. 1 and 2).
Fig. 1
We report the case of a 32-year-old male patient with neurofibromatosis type 1 (NF1) affected by a brainstem glioma (BSG). The patient underwent brain magnetic resonance imaging (MRI) for the onset of diplopia, facial paresis and cerebellar signs and symptoms. Coronal (a, b) and axial (c, d) enhanced T1-weighted (a, c) and T2-weighted (b, d) MR images showed the presence of a pontine-based infiltrative lesion (arrows), which presented inhomogenous signal intensity on both T1-weighted and T2-weighted images for the coexistence of isointense and hyperintense areas. These MRI findings were suggestive of a BSG
Fig. 2
The biopsy of the lesion was not performed and the patient underwent 18F-FDG-PET/CT for the metabolic characterization of this brainstem lesion. Before 18F-FDG injection, the patient had fasted for at least 6 h; at the time of the radiopharmaceutical injection, the patient presented glucose blood levels corresponding to 99 mg/dL. Images were acquired 1 h after intravenous injection of 280 MBq of 18F-FDG according to the body mass index. The unenhanced CT scan was performed from the vertex to the inguinal region with a voltage of 120 keV and tube current of 30 mA. This scan was used for the anatomic localization and the attenuation correction of PET data. PET scan was acquired in 3D mode (multiple bed positions, 3 min for each bed position). Iterative reconstruction and CT-based attenuation correction were used. Whole-body maximum intensity projection (MIP) 18F-FDG-PET image (a) showed an area of intense 18F-FDG uptake in the brainstem (arrow). 18F-FDG-PET (b–d), unenhanced CT (e–g) and fused PET/CT images (h–j), in axial (b, e, h), sagittal (c, f, i) and coronal (d, g, j) projection showed increased radiopharmaceutical uptake corresponding to the known brainstem lesion, with a maximal standardized uptake value of 10.7, suggesting the presence of an aggressive neoplasm
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