Skip to main content
Top
Published in: BMC Pediatrics 1/2009

Open Access 01-12-2009 | Research article

Use of the Italian version of the Pediatric Asthma Quality of Life Questionnaire in the daily practice: results of a prospective study

Authors: Giampaolo Ricci, Arianna Dondi, Elena Baldi, Barbara Bendandi, Arianna Giannetti, Massimo Masi

Published in: BMC Pediatrics | Issue 1/2009

Login to get access

Abstract

Background

Asthma is a serious global health problem and its prevalence is increasing, especially among children. It represents a significant social and economic burden, and it can severely affect the health-related quality of life (HRQL) of patients. Among the numerous questionnaires aiming at evaluating asthma HRQL in children, the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) has proved to have good measurement properties.
The present study was aimed at investigating the possible role of the Italian, self-administered version of the PAQLQ in the routine clinical evaluation of children affected by bronchial asthma.

Methods

52 Italian children and adolescents (40 males and 12 females), aged 6 to 17 years, affected by allergic asthma, were enrolled. Each patient was evaluated twice, and at each visit asthma control and severity were assessed, spirometry was performed and the patients completed the self-administered version of the PAQLQ.

Results

The questionnaire was well-accepted and understood by the children. Children showed an overall good quality of life, with mild impairment in the activity and emotional function domains. The PAQLQ showed an overall good correlation with the clinical and functional indexes that are normally evaluated in follow-up visits of asthmatic patients. The PAQLQ appeared to be strongly related to asthma control, both at the first (p < 0.01) and second (p < 0.001) time of the study. The PAQLQ was also seen to decrease with increasing asthma severity. The results suggest a better compliance of the children towards completion of the questionnaire at t1. Finally, the PAQLQ does not appear to discriminate HRQL in patients with good lung function.

Conclusion

The Italian version of the PAQLQ is a quick-to-administer aid to clinical activity and can add valuable information to symptom reports, objective measurements and clinical assessment of asthma control and severity in daily clinical practice. Re-administration at each follow-up visit allows HRQL to be monitored over time.
Appendix
Available only for authorised users
Literature
1.
go back to reference Constitution of the World Health Organization. Handbook of basic documents. 1952, World Health Organization. Geneva: Palais des Nations, 3-20. 5 Constitution of the World Health Organization. Handbook of basic documents. 1952, World Health Organization. Geneva: Palais des Nations, 3-20. 5
2.
go back to reference Testa MA, Simonson DC: Assessment of quality-of-life outcomes. N Engl J Med. 1996, 334: 835-40. 10.1056/NEJM199603283341306.CrossRefPubMed Testa MA, Simonson DC: Assessment of quality-of-life outcomes. N Engl J Med. 1996, 334: 835-40. 10.1056/NEJM199603283341306.CrossRefPubMed
3.
go back to reference Rutishauser C, Sawyer SM, Bowes G: Quality-of-life assessment in children and adolescents with asthma. Eur Respir J. 1998, 12: 486-94. 10.1183/09031936.98.12020486.CrossRefPubMed Rutishauser C, Sawyer SM, Bowes G: Quality-of-life assessment in children and adolescents with asthma. Eur Respir J. 1998, 12: 486-94. 10.1183/09031936.98.12020486.CrossRefPubMed
4.
go back to reference Schumacher M, Olschewski M, Schulgen G: Assessment of quality of life in clinical trials. Stat Med. 1991, 10: 1915-30. 10.1002/sim.4780101207.CrossRefPubMed Schumacher M, Olschewski M, Schulgen G: Assessment of quality of life in clinical trials. Stat Med. 1991, 10: 1915-30. 10.1002/sim.4780101207.CrossRefPubMed
5.
go back to reference Schipper H, Clinch J, Powell V: Definitions and conceptual issues. Quality of Life Assessments in Clinical Trials. Edited by: Spilker B. 1990, New York: Raven Press, 11-35. Schipper H, Clinch J, Powell V: Definitions and conceptual issues. Quality of Life Assessments in Clinical Trials. Edited by: Spilker B. 1990, New York: Raven Press, 11-35.
6.
go back to reference Simon AE, Chan KS, Forrest CB: Assessment of children's health-related quality of life in the United States with a multidimensional index. Pediatrics. 2008, 121: e118-126. 10.1542/peds.2007-0480.CrossRefPubMed Simon AE, Chan KS, Forrest CB: Assessment of children's health-related quality of life in the United States with a multidimensional index. Pediatrics. 2008, 121: e118-126. 10.1542/peds.2007-0480.CrossRefPubMed
7.
go back to reference Bacharier LB, Boner A, Carlsen KH, Eigenmann PA, Frischer T, Götz M, Helms PJ, Hunt J, Liu A, Papadopoulos N, Platts-Mills T, Pohunek P, Simons FE, Valovirta E, Wahn U, Wildhaber J, European Pediatric Asthma Group: Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy. 2008, 63: 5-34. 10.1111/j.1398-9995.2008.01640.x.CrossRefPubMed Bacharier LB, Boner A, Carlsen KH, Eigenmann PA, Frischer T, Götz M, Helms PJ, Hunt J, Liu A, Papadopoulos N, Platts-Mills T, Pohunek P, Simons FE, Valovirta E, Wahn U, Wildhaber J, European Pediatric Asthma Group: Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy. 2008, 63: 5-34. 10.1111/j.1398-9995.2008.01640.x.CrossRefPubMed
8.
go back to reference Baiardini I, Braido F, Brandi S, Canonica GW: Allergic diseases and their impact on quality of life. Ann Allergy Asthma Immunol. 2006, 97: 419-28.CrossRefPubMed Baiardini I, Braido F, Brandi S, Canonica GW: Allergic diseases and their impact on quality of life. Ann Allergy Asthma Immunol. 2006, 97: 419-28.CrossRefPubMed
9.
go back to reference Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H, ISAAC Phase Three Study Group: Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006, 368: 733-43. 10.1016/S0140-6736(06)69283-0.CrossRefPubMed Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, Williams H, ISAAC Phase Three Study Group: Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006, 368: 733-43. 10.1016/S0140-6736(06)69283-0.CrossRefPubMed
10.
go back to reference Sennahauser FH, Braun-Fahrländer C, Wildhaber JH: The burden of asthma in children: a European perspective. Paediatr Respir Rev. 2005, 6: 2-7. 10.1016/j.prrv.2004.11.001.CrossRef Sennahauser FH, Braun-Fahrländer C, Wildhaber JH: The burden of asthma in children: a European perspective. Paediatr Respir Rev. 2005, 6: 2-7. 10.1016/j.prrv.2004.11.001.CrossRef
11.
go back to reference Global Strategy for Asthma Management and Prevention: Mortality and morbidity. 2002, Bethesda, MD: National Heart, Lung and Blood Institute, NIH, 16-18. Global Strategy for Asthma Management and Prevention: Mortality and morbidity. 2002, Bethesda, MD: National Heart, Lung and Blood Institute, NIH, 16-18.
12.
go back to reference Juniper E, Fabbri LM, Boner A: Asma e qualità di vita. Strumenti per la valutazione delle limitazioni funzionali e dello stato di benessere. 1999, Roma: II Pensiero Scientifico Editore Juniper E, Fabbri LM, Boner A: Asma e qualità di vita. Strumenti per la valutazione delle limitazioni funzionali e dello stato di benessere. 1999, Roma: II Pensiero Scientifico Editore
13.
go back to reference Annett RD, Bender BG, Lapidus J, Duhamel TR, Lincoln A: Predicting children's quality of life in an asthma clinical trial: what do children's report tell us?. J Pediatr. 2001, 139: 854-61. 10.1067/mpd.2001.119444.CrossRefPubMed Annett RD, Bender BG, Lapidus J, Duhamel TR, Lincoln A: Predicting children's quality of life in an asthma clinical trial: what do children's report tell us?. J Pediatr. 2001, 139: 854-61. 10.1067/mpd.2001.119444.CrossRefPubMed
14.
go back to reference Fabbri LM, Stoloff S: Is mild asthma really mild?. Int J Clin Practice. 2005, 59: 692-703. 10.1111/j.1742-1241.2005.00505.x.CrossRef Fabbri LM, Stoloff S: Is mild asthma really mild?. Int J Clin Practice. 2005, 59: 692-703. 10.1111/j.1742-1241.2005.00505.x.CrossRef
15.
go back to reference Juniper EF: How important is quality of life in pediatric asthma?. Pediatr Pulmonol Suppl. 1997, 15: 17-21. 10.1002/(SICI)1099-0496(199709)15+<17::AID-PPUL5>3.0.CO;2-O.CrossRefPubMed Juniper EF: How important is quality of life in pediatric asthma?. Pediatr Pulmonol Suppl. 1997, 15: 17-21. 10.1002/(SICI)1099-0496(199709)15+<17::AID-PPUL5>3.0.CO;2-O.CrossRefPubMed
16.
go back to reference Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M: Measuring quality of life in children with asthma. Qual Life Res. 1996, 5: 35-46. 10.1007/BF00435967.CrossRefPubMed Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M: Measuring quality of life in children with asthma. Qual Life Res. 1996, 5: 35-46. 10.1007/BF00435967.CrossRefPubMed
17.
go back to reference Guillemin F, Bombardier C, Beaton D: Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. J Clin Epidemiol. 1993, 46: 1417-32. 10.1016/0895-4356(93)90142-N.CrossRefPubMed Guillemin F, Bombardier C, Beaton D: Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. J Clin Epidemiol. 1993, 46: 1417-32. 10.1016/0895-4356(93)90142-N.CrossRefPubMed
19.
go back to reference Bateman ED, Frith LF, Braunstein GL: Achieving guideline-based asthma control: does the patient benefit?. Eur Respir J. 2002, 20: 588-95. 10.1183/09031936.02.00294702.CrossRefPubMed Bateman ED, Frith LF, Braunstein GL: Achieving guideline-based asthma control: does the patient benefit?. Eur Respir J. 2002, 20: 588-95. 10.1183/09031936.02.00294702.CrossRefPubMed
20.
go back to reference Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology and Joint Council of Allergy, Asthma and Immunology: Attaining optimal asthma control: a practice parameter. J Allergy Clin Immunol. 2005, 116 (5): S3-11. 10.1016/j.jaci.2005.08.017.CrossRef Joint Task Force on Practice Parameters, American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology and Joint Council of Allergy, Asthma and Immunology: Attaining optimal asthma control: a practice parameter. J Allergy Clin Immunol. 2005, 116 (5): S3-11. 10.1016/j.jaci.2005.08.017.CrossRef
22.
go back to reference Reichenberg K, Broberg AG: Quality of life in childhood asthma: use of the Paediatric Asthma Quality of Life Questionnaire in a Swedish sample of children 7 to 9 years old. Acta Paediatr. 2000, 89: 989-95. 10.1080/080352500750043495.CrossRefPubMed Reichenberg K, Broberg AG: Quality of life in childhood asthma: use of the Paediatric Asthma Quality of Life Questionnaire in a Swedish sample of children 7 to 9 years old. Acta Paediatr. 2000, 89: 989-95. 10.1080/080352500750043495.CrossRefPubMed
23.
go back to reference Tauler E, Vilagut G, Grau G, González A, Sánchez E, Figueras G, Vall O, Ferrer M, Alonso J: The Spanish version of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ): metric characteristics and equivalence with the original version. Qual Life Res. 2001, 10: 81-91. 10.1023/A:1016622519987.CrossRefPubMed Tauler E, Vilagut G, Grau G, González A, Sánchez E, Figueras G, Vall O, Ferrer M, Alonso J: The Spanish version of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ): metric characteristics and equivalence with the original version. Qual Life Res. 2001, 10: 81-91. 10.1023/A:1016622519987.CrossRefPubMed
24.
go back to reference Raat H, Bueving HJ, de Jongste JC, Grol MH, Juniper EF, Wouden van der JC: Responsiveness, longitudinal- and cross-sectional validity of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Dutch children with asthma. Qual Life Res. 2005, 14: 265-72.CrossRefPubMed Raat H, Bueving HJ, de Jongste JC, Grol MH, Juniper EF, Wouden van der JC: Responsiveness, longitudinal- and cross-sectional validity of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Dutch children with asthma. Qual Life Res. 2005, 14: 265-72.CrossRefPubMed
25.
go back to reference Wu AC, Smith L, Bokhour B, Hohman KH, Lieu TA: Racial/ethnic variation in parent perceptions of asthma. Ambul Pediatr. 2008, 8: 89-97. 10.1016/j.ambp.2007.10.007.CrossRefPubMedPubMedCentral Wu AC, Smith L, Bokhour B, Hohman KH, Lieu TA: Racial/ethnic variation in parent perceptions of asthma. Ambul Pediatr. 2008, 8: 89-97. 10.1016/j.ambp.2007.10.007.CrossRefPubMedPubMedCentral
26.
go back to reference Williams J, Williams K: Asthma-specific quality of life questionnaires in children: are they useful and feasible in routine clinical practice?. Pediatr Pulmonol. 2003, 35: 114-18. 10.1002/ppul.10206.CrossRefPubMed Williams J, Williams K: Asthma-specific quality of life questionnaires in children: are they useful and feasible in routine clinical practice?. Pediatr Pulmonol. 2003, 35: 114-18. 10.1002/ppul.10206.CrossRefPubMed
27.
go back to reference Reichenberg K, Broberg AG: To the editor: Re: "Asthma-specific quality of life questionnaires in children: are they useful and feasible in routine clinical practice?". Pediatr Pulmonol. 2003, 36: 552-53. 10.1002/ppul.10328.CrossRefPubMed Reichenberg K, Broberg AG: To the editor: Re: "Asthma-specific quality of life questionnaires in children: are they useful and feasible in routine clinical practice?". Pediatr Pulmonol. 2003, 36: 552-53. 10.1002/ppul.10328.CrossRefPubMed
28.
go back to reference Mussaffi H, Omer R, Prais D, Mei-Zahav M, Weiss-Kasirer T, Botzer Z, Blau H: Computerized paediatric asthma quality of life questionnaires in routine care. Arch Dis Child. 2007, 92: 678-682. 10.1136/adc.2006.111971.CrossRefPubMedPubMedCentral Mussaffi H, Omer R, Prais D, Mei-Zahav M, Weiss-Kasirer T, Botzer Z, Blau H: Computerized paediatric asthma quality of life questionnaires in routine care. Arch Dis Child. 2007, 92: 678-682. 10.1136/adc.2006.111971.CrossRefPubMedPubMedCentral
29.
go back to reference Juniper EF: Interpreting quality of life data: should we listen to the patient or the clinician?. Ann Allergy Asthma Immunol. 2003, 91: 115-16.CrossRefPubMed Juniper EF: Interpreting quality of life data: should we listen to the patient or the clinician?. Ann Allergy Asthma Immunol. 2003, 91: 115-16.CrossRefPubMed
30.
go back to reference Bailey WC, Higgins DM, Richards BM, Richards JM: Asthma severity: a factor analytic investigation. Am J Med. 1992, 93: 263-69. 10.1016/0002-9343(92)90231-Y.CrossRefPubMed Bailey WC, Higgins DM, Richards BM, Richards JM: Asthma severity: a factor analytic investigation. Am J Med. 1992, 93: 263-69. 10.1016/0002-9343(92)90231-Y.CrossRefPubMed
31.
go back to reference Juniper EF, Wisniewski ME, Cox FM, Emmett AH, Nielsen KE, O'Byrne PM: Relationship between quality of life and clinical status in asthma: a factor analysis. Eur Respir J. 2004, 23: 287-91. 10.1183/09031936.04.00064204.CrossRefPubMed Juniper EF, Wisniewski ME, Cox FM, Emmett AH, Nielsen KE, O'Byrne PM: Relationship between quality of life and clinical status in asthma: a factor analysis. Eur Respir J. 2004, 23: 287-91. 10.1183/09031936.04.00064204.CrossRefPubMed
32.
go back to reference Schatz M, Mosen D, Apter AJ, Zeiger RS, Vollmer WM, Stibolt TB, Leong A, Johnson MS, Mendoza G, Cook EF: Relationships among quality of life, severity, and control measures in asthma: an evaluation using factor analysis. J Allergy Clin Immunol. 2005, 115: 1049-55. 10.1016/j.jaci.2005.02.008.CrossRefPubMed Schatz M, Mosen D, Apter AJ, Zeiger RS, Vollmer WM, Stibolt TB, Leong A, Johnson MS, Mendoza G, Cook EF: Relationships among quality of life, severity, and control measures in asthma: an evaluation using factor analysis. J Allergy Clin Immunol. 2005, 115: 1049-55. 10.1016/j.jaci.2005.02.008.CrossRefPubMed
Metadata
Title
Use of the Italian version of the Pediatric Asthma Quality of Life Questionnaire in the daily practice: results of a prospective study
Authors
Giampaolo Ricci
Arianna Dondi
Elena Baldi
Barbara Bendandi
Arianna Giannetti
Massimo Masi
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2009
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/1471-2431-9-30

Other articles of this Issue 1/2009

BMC Pediatrics 1/2009 Go to the issue