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01-07-2017 | Review

Use of platelet-rich fibrin in regenerative dentistry: a systematic review

Authors: Richard J. Miron, Giovanni Zucchelli, Michael A. Pikos, Maurice Salama, Samuel Lee, Vincent Guillemette, Masako Fujioka-Kobayashi, Mark Bishara, Yufeng Zhang, Hom-Lay Wang, Fatiha Chandad, Cleopatra Nacopoulos, Alain Simonpieri, Alexandre Amir Aalam, Pietro Felice, Gilberto Sammartino, Shahram Ghanaati, Maria A Hernandez, Joseph Choukroun

Published in: Clinical Oral Investigations | Issue 6/2017

Abstract

Objectives

Research across many fields of medicine now points towards the clinical advantages of combining regenerative procedures with platelet-rich fibrin (PRF). This systematic review aimed to gather the extensive number of articles published to date on PRF in the dental field to better understand the clinical procedures where PRF may be utilized to enhance tissue/bone formation.

Materials and methods

Manuscripts were searched systematically until May 2016 and separated into the following categories: intrabony and furcation defect regeneration, extraction socket management, sinus lifting procedures, gingival recession treatment, and guided bone regeneration (GBR) including horizontal/vertical bone augmentation procedures. Only human randomized clinical trials were included for assessment.

Results

In total, 35 articles were selected and divided accordingly (kappa = 0.94). Overall, the use of PRF has been most investigated in periodontology for the treatment of periodontal intrabony defects and gingival recessions where the majority of studies have demonstrated favorable results in soft tissue management and repair. Little to no randomized clinical trials were found for extraction socket management although PRF has been shown to significantly decrease by tenfold dry sockets of third molars. Very little to no data was available directly investigating the effects of PRF on new bone formation in GBR, horizontal/vertical bone augmentation procedures, treatment of peri-implantitis, and sinus lifting procedures.

Conclusions

Much investigation now supports the use of PRF for periodontal and soft tissue repair. Despite this, there remains a lack of well-conducted studies demonstrating convincingly the role of PRF during hard tissue bone regeneration. Future human randomized clinical studies evaluating the use of PRF on bone formation thus remain necessary.

Clinical relevance

PRF was shown to improve soft tissue generation and limit dimensional changes post-extraction, with little available data to date supporting its use in GBR.

Available only for authorised users

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Title: Use of platelet-rich fibrin in regenerative dentistry: a systematic review
Authors: Richard J. Miron
Giovanni Zucchelli
Michael A. Pikos
Maurice Salama
Samuel Lee
Vincent Guillemette
Masako Fujioka-Kobayashi
Mark Bishara
Yufeng Zhang
Hom-Lay Wang
Fatiha Chandad
Cleopatra Nacopoulos
Alain Simonpieri
Alexandre Amir Aalam
Pietro Felice
Gilberto Sammartino
Shahram Ghanaati
Maria A Hernandez
Joseph Choukroun
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Oral Investigations / Issue 6/2017
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-017-2133-z

At a glance: The STEP trials

Springer Medicine

Use of platelet-rich fibrin in regenerative dentistry: a systematic review

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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