Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Use of near-infrared light to reduce symptoms associated with restless legs syndrome in a woman: a case report

Author: Ulrike H Mitchell

Published in: Journal of Medical Case Reports | Issue 1/2010

Login to get access

Abstract

Introduction

We describe a potential new treatment option for patients suffering from restless legs syndrome. Contemporary treatment for restless legs syndrome consists mostly of dopaminergic drugs that leave some patients feeling nauseated and dizzy. A non-invasive, drug-free option would open new doors for patients suffering from restless legs syndrome.

Case presentation

A 69-year-old Caucasian woman met International Restless Legs Syndrome Study Group criteria for the diagnosis of restless legs syndrome. She had been afflicted with restless legs syndrome for over 30 years and tried many of the available pharmaceutical remedies without success. For this study she received 30-minute treatment sessions with near-infrared light, three times a week for four weeks. The restless legs syndrome rating scale was used to track symptom changes; at baseline she scored "27" on the 0 to 40 point scale, which is considered to be "severe". Our patient was almost symptom free at week two, indicated by a score of "2" on the rating scale. By week four she was completely symptom free. The symptoms slowly returned during week three post treatment.

Conclusions

The findings suggest that near-infrared light may be a feasible method for treating patients suffering from restless legs syndrome. Undesirable side-effects from medication are non-existent. This study might revive the neglected vascular mechanism theory behind restless legs syndrome and encourage further research into this area.
Appendix
Available only for authorised users
Literature
1.
go back to reference Kushida C, Allen R, Atkinson M: Modeling the causal relationship between symptoms associated with restless legs syndrome and the patient-reported impact of RLS. Sleep Med. 2004, 5: 485-488. 10.1016/j.sleep.2004.04.004.CrossRefPubMed Kushida C, Allen R, Atkinson M: Modeling the causal relationship between symptoms associated with restless legs syndrome and the patient-reported impact of RLS. Sleep Med. 2004, 5: 485-488. 10.1016/j.sleep.2004.04.004.CrossRefPubMed
3.
go back to reference Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J: Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003, 4: 101-119. 10.1016/S1389-9457(03)00010-8.CrossRefPubMed Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J: Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003, 4: 101-119. 10.1016/S1389-9457(03)00010-8.CrossRefPubMed
4.
go back to reference The International Restless Legs Syndrome Study Group: Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003, 4: 121-132. 10.1016/S1389-9457(02)00258-7.CrossRef The International Restless Legs Syndrome Study Group: Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003, 4: 121-132. 10.1016/S1389-9457(02)00258-7.CrossRef
5.
go back to reference Hoegl B, Gschliesser V: RLS assessment and sleep questionnaires in practice - Lessons learned from Parkinson's disease. Sleep Med. 2007, 8: S7-S12. 10.1016/j.sleep.2007.04.008.CrossRef Hoegl B, Gschliesser V: RLS assessment and sleep questionnaires in practice - Lessons learned from Parkinson's disease. Sleep Med. 2007, 8: S7-S12. 10.1016/j.sleep.2007.04.008.CrossRef
6.
go back to reference Ondo W: Restless legs syndrome. Neurologic Clinics. 2009, 27 (3): 779-799. 10.1016/j.ncl.2009.04.007.CrossRefPubMed Ondo W: Restless legs syndrome. Neurologic Clinics. 2009, 27 (3): 779-799. 10.1016/j.ncl.2009.04.007.CrossRefPubMed
7.
go back to reference Ferini-Strambi L, Aarskog D, Partinen M, Chaudhuri K, Sohr M, Verri D, Albrecht S: Effect of pramipexole on RLS symptoms and sleep: A randomized, double-blind, placebo-controlled trial. Sleep Med. 2008, 9 (8): 874-881. 10.1016/j.sleep.2008.09.001.CrossRefPubMed Ferini-Strambi L, Aarskog D, Partinen M, Chaudhuri K, Sohr M, Verri D, Albrecht S: Effect of pramipexole on RLS symptoms and sleep: A randomized, double-blind, placebo-controlled trial. Sleep Med. 2008, 9 (8): 874-881. 10.1016/j.sleep.2008.09.001.CrossRefPubMed
8.
go back to reference Silber M, Girish M, Izurieta R: Pramipexole in the management of restless legs syndrome; an extended study. Sleep. 2003, 26 (7): 819-821.PubMed Silber M, Girish M, Izurieta R: Pramipexole in the management of restless legs syndrome; an extended study. Sleep. 2003, 26 (7): 819-821.PubMed
9.
go back to reference Thorpy M: New paradigms in the treatment of restless legs syndrome. Neurology. 2005, 64 (Supplement 3): S28-S33.CrossRefPubMed Thorpy M: New paradigms in the treatment of restless legs syndrome. Neurology. 2005, 64 (Supplement 3): S28-S33.CrossRefPubMed
10.
go back to reference Anodyne Therapy: Anodyne therapy professional system, model 480, important safety information and instructions. 2005 Anodyne Therapy: Anodyne therapy professional system, model 480, important safety information and instructions. 2005
11.
go back to reference Horwitz L, Burke T, Carnegie D: Augmentation of wound healing using monochromatic infrared energy. Adv Wound Care. 1999, 12: 35-40.PubMed Horwitz L, Burke T, Carnegie D: Augmentation of wound healing using monochromatic infrared energy. Adv Wound Care. 1999, 12: 35-40.PubMed
12.
go back to reference Culotta E, Koshland D: NO news is good news. Science. 1992, 258 (5090): 1862-1865. 10.1126/science.1361684.CrossRefPubMed Culotta E, Koshland D: NO news is good news. Science. 1992, 258 (5090): 1862-1865. 10.1126/science.1361684.CrossRefPubMed
13.
go back to reference Buga G, Gold M, Fukuto J, Ingarro L: Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension. 1991, 17: 187-193.CrossRefPubMed Buga G, Gold M, Fukuto J, Ingarro L: Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension. 1991, 17: 187-193.CrossRefPubMed
14.
go back to reference Vladimirov Y, Borisenkoa G, Boriskinaa N, Kazarinovb K, Osipova A: NO-hemoglobin may be a light-sensitive source of nitric oxide both in solution and in red blood cells. J Photochem Photobiol B. 2000, 59 (1-3): 115-122. 10.1016/S1011-1344(00)00148-2.CrossRefPubMed Vladimirov Y, Borisenkoa G, Boriskinaa N, Kazarinovb K, Osipova A: NO-hemoglobin may be a light-sensitive source of nitric oxide both in solution and in red blood cells. J Photochem Photobiol B. 2000, 59 (1-3): 115-122. 10.1016/S1011-1344(00)00148-2.CrossRefPubMed
15.
go back to reference Phillips B, Hening W, Britz P, Mannino D: Prevalence and Correlates of Restless Legs Syndrome: Results From the 2005 National Sleep Foundation Poll. Chest. 2006, 129: 76-80. 10.1378/chest.129.1.76.CrossRefPubMed Phillips B, Hening W, Britz P, Mannino D: Prevalence and Correlates of Restless Legs Syndrome: Results From the 2005 National Sleep Foundation Poll. Chest. 2006, 129: 76-80. 10.1378/chest.129.1.76.CrossRefPubMed
16.
go back to reference Rajaram S, Shanahan J, Ash C, Walters A, Weisfogel G: Enhanced external counter pulsation (EECP) as a novel treatment for restless legs syndrome (RLS): a preliminary test of the vascular neurologic hypothesis for RLS. Sleep Med. 2005, 6: 101-106. 10.1016/j.sleep.2004.10.012.CrossRefPubMed Rajaram S, Shanahan J, Ash C, Walters A, Weisfogel G: Enhanced external counter pulsation (EECP) as a novel treatment for restless legs syndrome (RLS): a preliminary test of the vascular neurologic hypothesis for RLS. Sleep Med. 2005, 6: 101-106. 10.1016/j.sleep.2004.10.012.CrossRefPubMed
17.
go back to reference McDonagh B, King T, Guptan R: RLS in patients with chronic venous disorder. Phlebology. 2007, 22 (4): 156-163. 10.1258/026835507781477145.CrossRefPubMed McDonagh B, King T, Guptan R: RLS in patients with chronic venous disorder. Phlebology. 2007, 22 (4): 156-163. 10.1258/026835507781477145.CrossRefPubMed
18.
go back to reference Clifford P, Hellsten Y: Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol. 2004, 97: 393-403. 10.1152/japplphysiol.00179.2004.CrossRefPubMed Clifford P, Hellsten Y: Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol. 2004, 97: 393-403. 10.1152/japplphysiol.00179.2004.CrossRefPubMed
19.
go back to reference Matsunaga K, Furchgott R: Interactions of light and sodium nitrite in producing relaxation of rabbit aorta. J Pharmacol Exp Ther. 1989, 248: 687-694.PubMed Matsunaga K, Furchgott R: Interactions of light and sodium nitrite in producing relaxation of rabbit aorta. J Pharmacol Exp Ther. 1989, 248: 687-694.PubMed
20.
go back to reference Burke T: 5 Questions-and Answers-About MIRE Treatment. Adv Skin Wound Care. 2003, 16 (7): 369-371. 10.1097/00129334-200312000-00016.CrossRefPubMed Burke T: 5 Questions-and Answers-About MIRE Treatment. Adv Skin Wound Care. 2003, 16 (7): 369-371. 10.1097/00129334-200312000-00016.CrossRefPubMed
21.
go back to reference Ignarro L, Buga G, Wood K, Byrns R: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 1987, 84: 9265-9269. 10.1073/pnas.84.24.9265.CrossRefPubMedPubMedCentral Ignarro L, Buga G, Wood K, Byrns R: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 1987, 84: 9265-9269. 10.1073/pnas.84.24.9265.CrossRefPubMedPubMedCentral
22.
go back to reference Moncada S, Palmer R, Higgs E: Nitric Oxide: Physiology, Pathophysiology, and Pharmacology. Pharmacol Rev. 1991, 43 (2): 109-142.PubMed Moncada S, Palmer R, Higgs E: Nitric Oxide: Physiology, Pathophysiology, and Pharmacology. Pharmacol Rev. 1991, 43 (2): 109-142.PubMed
23.
go back to reference Hawkins D, Abrahamse H: Phototherapy - a treatment modality for wound healing and pain relief. African Journal of Biomedical Research. 2007, 10: 99-109. Hawkins D, Abrahamse H: Phototherapy - a treatment modality for wound healing and pain relief. African Journal of Biomedical Research. 2007, 10: 99-109.
24.
go back to reference Trenkwalder C, Paulus W: Why do restless legs occur at rest? - pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2). Clin Neurol. 2004, 115: 1975-1988. 10.1016/j.clinph.2004.01.031. Trenkwalder C, Paulus W: Why do restless legs occur at rest? - pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2). Clin Neurol. 2004, 115: 1975-1988. 10.1016/j.clinph.2004.01.031.
25.
go back to reference Winkelmann J, Wetter T, Collado-Seidel V, Gasser T, Dichgans M, Yassouridis A, Trenkwalder C: Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep. 2000, 23 (5): 597-602.PubMed Winkelmann J, Wetter T, Collado-Seidel V, Gasser T, Dichgans M, Yassouridis A, Trenkwalder C: Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients. Sleep. 2000, 23 (5): 597-602.PubMed
26.
go back to reference Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peglau I, Eisensehr I: Variants in the Neuronal Nitric Oxide Synthase (nNOS, NOS1) Gene are Associated with Restless Legs Syndrome. Mov Disord. 2008, 23 (3): 350-358. 10.1002/mds.21647.CrossRefPubMed Winkelmann J, Lichtner P, Schormair B, Uhr M, Hauk S, Stiasny-Kolster K, Trenkwalder C, Paulus W, Peglau I, Eisensehr I: Variants in the Neuronal Nitric Oxide Synthase (nNOS, NOS1) Gene are Associated with Restless Legs Syndrome. Mov Disord. 2008, 23 (3): 350-358. 10.1002/mds.21647.CrossRefPubMed
27.
go back to reference Fulda S, Wetter T: Where dopamine meets opioids: a meta-analysis of the placebo effect in RLS treatment studies. Brain. 2007, 131: 902-917. 10.1093/brain/awm244.CrossRefPubMed Fulda S, Wetter T: Where dopamine meets opioids: a meta-analysis of the placebo effect in RLS treatment studies. Brain. 2007, 131: 902-917. 10.1093/brain/awm244.CrossRefPubMed
Metadata
Title
Use of near-infrared light to reduce symptoms associated with restless legs syndrome in a woman: a case report
Author
Ulrike H Mitchell
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-286

Other articles of this Issue 1/2010

Journal of Medical Case Reports 1/2010 Go to the issue