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Journal of Ophthalmic Inflammation and Infection

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Open Access 01-12-2013 | Brief report

Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits

Authors: Magda Luzia Neves, Letícia Yamasaki, Osimar de Carvalho Sanches, Marcelo Sávio Paiva do Amaral, Helaine Stevanin, Rogério Giuffrida, Eudes Ramalho Candido, Jonatas Eduardo Góes, Luís Felipe da Costa Zulim, Augusto Schweigert, Rosimery Missuzu Fukui, Carlos Collares Meirelles, Carolina Akemi Sasaki, Silvia Franco Andrade

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2013

Abstract

Background

The objective of this study was to evaluate the effectiveness of various linseed oil (LO) preparations (oral, topical, oral and topical combined) in treating experimentally induced keratoconjunctivitis sicca (KCS) in rabbits. Twenty male New Zealand white rabbits were divided into four groups: group C (control), group OLO (oral LO), group TLO (topical LO), and group OTLO (oral and topical LO). The animals were evaluated weekly using Schirmer's tear test (STT), fluorescein test (FT), and Rose Bengal test (RBT) and were euthanized at the end of the experiment for histopathological analysis.

Findings

There were significant improvements in the parameters analyzed (STT, FT, and RBT) and in the histopathological finding in all of the groups using LO.

Conclusions

The analyzed results demonstrate that LO, administered orally or topically, was effective in treating experimentally induced KCS in rabbits, although combined oral and topical LO did not show additional benefits greater than those with a single route of administration.

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Title: Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits
Authors: Magda Luzia Neves
Letícia Yamasaki
Osimar de Carvalho Sanches
Marcelo Sávio Paiva do Amaral
Helaine Stevanin
Rogério Giuffrida
Eudes Ramalho Candido
Jonatas Eduardo Góes
Luís Felipe da Costa Zulim
Augusto Schweigert
Rosimery Missuzu Fukui
Carlos Collares Meirelles
Carolina Akemi Sasaki
Silvia Franco Andrade
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: Journal of Ophthalmic Inflammation and Infection / Issue 1/2013
Electronic ISSN: 1869-5760
DOI: https://doi.org/10.1186/1869-5760-3-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Use of linseed oil to treat experimentally induced keratoconjunctivitis sicca in rabbits

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusions

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