Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2013

Open Access 01-12-2013 | Research

Use of health-related quality of life measures to predict health utility in postmenopausal osteoporotic women: results from the Multiple Outcomes of Raloxifene Evaluation study

Authors: Russel Burge, Wei Shen, April N Naegeli, Jahangir Alam, Stuart Silverman, Deborah T Gold, Tsehua Shih

Published in: Health and Quality of Life Outcomes | Issue 1/2013

Login to get access

Abstract

Background

The aim of this study is to examine the associations between health utility (HU), health-related quality of life (HRQoL), and patient characteristics in postmenopausal osteoporotic (PMO) women.

Methods

Baseline data from a subsample of 1,245 participants of the Multiple Outcomes of Raloxifene Evaluation study, a randomized, placebo-controlled, multinational clinical trial to evaluate the safety and efficacy of raloxifene, were analyzed. The study cohort included 694 participants from non-European Union (non-EU) countries and 551 participants from EU countries. All participants with complete baseline HU and HRQoL assessments were included in the following analyses: 1) HU (HUI or EQ-5D) and HRQoL (QualEFFO or OPAQ and NHP) associations; 2) HU variability explained by HRQoL domains; and 3) the percentage of HU variability explained by statistically significant (p < 0.05) HRQoL domains, after adjusting for baseline characteristics.

Results

Several domains were significantly associated with HU scores. HU variance was well explained (41% to 61%) by 4 to 6 (p < 0.05) significant HRQoL domains. After controlling for baseline characteristics, 48% to 64% of the HU variance was well explained by 5 to 7 significant (p < 0.05) HRQoL domains. Additional trend analyses detected statistically significant decreases in HRQoL and HU scores with an increased number of vertebral and non-vertebral fractures.

Conclusions

Both disease-targeted and generic HRQoL domains were well correlated with HU. A large percentage (48% to 64%) of the HU variance was explained by HRQoL, after adjusting for baseline characteristics. Both disease-targeted and generic HRQoL measures were significant predictors of HU. HRQoL and HU scores decreased with increased vertebral and non-vertebral fractures.
Appendix
Available only for authorised users
Literature
1.
2.
Reginster J-Y, Burlet N: Osteoporosis: a still increasing prevalence. Bone 2005, 38: S4-S9.CrossRef
3.
Cummings SR, Melton LJ: Epidemiology and outcomes of osteoporotic fractures. Lancet 2002, 359: 1761. 10.1016/S0140-6736(02)08657-9PubMedCrossRef
4.
Kanis JA, on behalf of the World Health Organization Scientific Group Technical Report. World Health Organization Collaborating Centre for Metabolic Bone Diseases. In Assessment of Osteoporosis at the Primary Health-Care Level. Sheffield: University of Sheffield; 2007.
5.
U.S. Department of Health and Human Services (USDHHS): Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville: Office of the Surgeon General; 2004.
6.
7.
Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Johnell O, Kanis JA, Kellingray S, Leplege A, Liberman UA, McCloskey E, Minne H, Reeve J, Reginster JY, Scholz M, Todd C, de Vernejoul MC, Wiklund I, on behalf of the Working Party for Quality of Life of the European Foundation for Osteoporosis: Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Osteoporos Int 1999, 10: 150–160. 10.1007/s001980050210PubMedCrossRef
8.
Nevitt MC, Ettinger B, Black DM, Stone K, Jamal SA, Ensrud K, Segal M, Genant HK, Cummings SR: The association of radiographically detected vertebral fractures with back pain and function: a prospective study. Ann Intern Med 1998, 128: 793–800. 10.7326/0003-4819-128-10-199805150-00001PubMedCrossRef
9.
Silverman SL, Minshall ME, Shen W, Harper KD, Xie S, on behalf of the Health-Related Quality of Life Subgroup of the Multiple Outcomes of Raloxifene Evaluation Study: The relationship of health-related quality of life to prevalent and incident vertebral fractures in postmenopausal women with osteoporosis: results from the Multiple Outcomes of Raloxifene Evaluation Study. Arthritis Rheum 2001, 44: 2611–2619. 10.1002/1529-0131(200111)44:11<2611::AID-ART441>3.0.CO;2-NPubMedCrossRef
10.
Oglesby AK, Minshall ME, Shen W, Xie S, Silverman SL: The impact of incident vertebral and non-vertebral fragility fractures on health-related quality of life in established postmenopausal osteoporosis: results from the teriparatide randomized, placebo-controlled trial in postmenopausal women. J Rheumatol 2003, 30: 1579–1583.PubMed
11.
Oleksik A, Lips P, Dawson A, Minshall ME, Shen W, Cooper C, Kanis J: Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures. J Bone Miner Res 2000, 15: 1384–1392. 10.1359/jbmr.2000.15.7.1384PubMedCrossRef
12.
Oleksik AM, Ewing S, Shen W, van Schoor NM, Lips P: Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures. Osteoporos Int 2005, 16: 861–870. 10.1007/s00198-004-1774-3PubMedCrossRef
13.
Adachi JD, Ioannidis G, Pickard L, Berger C, Prior JC, Joseph L, Hanley DA, Olszynski WP, Murray TM, Anastassiades T, Hopman W, Brown JP, Kirkland S, Joyce C, Papaioannou A, Poliquin S, Tenenhouse A, Papadimitropoulos EA: The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 2003, 14: 895–904. 10.1007/s00198-003-1483-3PubMedCrossRef
14.
Cockerill W, Lunt M, Silman AJ, Cooper C, Lips P, Bhalla AK, Cannata JB, Eastell R, Felsenberg D, Gennari C, Johnell O, Kanis JA, Kiss C, Masaryk P, Naves M, Poor G, Raspe H, Reid DM, Reeve J, Stepan J, Todd C, Woolf AD, O’Neill TW: Health-related quality of life and radiographic vertebral fracture. Osteoporos Int 2004, 15: 113–119. 10.1007/s00198-003-1547-4PubMedCrossRef
15.
Silverman SL: The Osteoporosis Assessment Questionnaire (OPAQ): a reliable and valid disease-targeted measure of health-related quality of life (HRQOL) in osteoporosis. Qual Life Res 2000, 9: 767–774. 10.1023/A:1008934208764CrossRef
16.
Lips P, van Schoor NM: Quality of life in patients with osteoporosis. Osteoporos Int 2005, 16: 447–455. 10.1007/s00198-004-1762-7PubMedCrossRef
17.
Peasgood T, Herrmann K, Kanis JA, Brazier JE: An updated systematic review of Health State Utility Values for osteoporosis related conditions. Osteoporos Int 2009, 20: 853–868. 10.1007/s00198-009-0844-yPubMedCrossRef
18.
Lipscomb J, Drummond M, Fryback D, Gold M, Revicki D: Retaining, and enhancing, the QALY. Value Health 2009,12(S1):S18-S26.PubMedCrossRef
19.
Marciniak A, Pfeilschifter J, Shepherd S, Wade S, Tosteson A, Freemantle N, Guillemin F, Martinez L, Calvert M, Cooper C, Ganiats T, Gitlin M, Horne R: Determinants of health-related quality of life in postmenopausal women receiving or initiating bone loss medications: POSSIBLE EU® AND POSSIBLE US™ [abstract]. Osteoporos Int 2011,22(Suppl 1):S252.
20.
McDonough CM, Grove MR, Elledge AD, Tosteson A: Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire. Osteoporos Int 2012, 23: 723–732. 10.1007/s00198-011-1619-9PubMedCentralPubMedCrossRef
21.
Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta JR, Stakkestad J, Glüer CC, Krueger K, Cohen FJ, Eckert S, Ensrud KE, Avioli LV, Lips P, Cummings SR, on behalf of the Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators: Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. JAMA 1999, 282: 637–645. 10.1001/jama.282.7.637PubMedCrossRef
22.
Hunt SM, McKenna SP, McEwen J, Williams J, Papp E: The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med A 1981, 15: 221–229.PubMed
23.
Tosteson AN, Hammond CS: Quality-of-life assessment in osteoporosis: health-status and preference-based measures. Pharmacoeconomics 2002, 20: 289–303. 10.2165/00019053-200220050-00001PubMedCrossRef
24.
Feeny D, Furlong W, Torrance GW, Goldsmith CH, Zhu Z, DePauw S, Denton M, Boyle M: Multiattribute and single-attribute utility functions for the health utilities index mark 3 system. Med Care 2002, 40: 113–128. 10.1097/00005650-200202000-00006PubMedCrossRef
25.
Brooks R: EuroQol: the current state of play. Health Policy 1996, 37: 53–72. 10.1016/0168-8510(96)00822-6PubMedCrossRef
26.
Fryback DG, Dunham NC, Palta M, Hanmer J, Beuchner J, Cherepanov D, Herrington SA, Hays RD, Kaplan RM, Ganiats TG, Feeny D, Kind P: US norms for six generic health-related quality-of-life indexes from the National Health Measurement study. Med Care 2007, 45: 1162–1170. 10.1097/MLR.0b013e31814848f1PubMedCentralPubMedCrossRef
27.
Luo N, Johnson JA, Shaw JW, Feeny D, Coons SJ: Self-reported health status of the general adult U.S. population as assessed by the EQ-5D and Health Utilities Index. Med Care 2005, 43: 1078–1086. 10.1097/01.mlr.0000182493.57090.c1PubMedCrossRef
Metadata
Title
Use of health-related quality of life measures to predict health utility in postmenopausal osteoporotic women: results from the Multiple Outcomes of Raloxifene Evaluation study
Authors
Russel Burge
Wei Shen
April N Naegeli
Jahangir Alam
Stuart Silverman
Deborah T Gold
Tsehua Shih
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2013
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-11-189

Other articles of this Issue 1/2013

Health and Quality of Life Outcomes 1/2013 Go to the issue

Research

Psychometric properties of the Fatigue Severity Scale in obese patients

Research

The quality of life of people with epilepsy at a tertiary referral centre in Malaysia

Research

Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire in diarrheal-predominant irritable bowel syndrome patients

Research

Health related quality of life of children with rheumatic heart diseases: reliability of the Brazilian version of the pediatric quality of life inventory™ cardiac module scale

Research

Posttraumatic growth, posttraumatic stress and psychological adjustment in the aftermath of the 2011 Oslo bombing attack

Letter to the Editor

A response to Gadarowski’s letter to the editor