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Open Access 01-12-2014 | Research

Use of FDG-PET to guide dose prescription heterogeneity in stereotactic body radiation therapy for lung cancers with volumetric modulated arc therapy: a feasibility study

Authors: Bénédicte Henriques de Figueiredo, Mikael Antoine, Renaud Trouette, Philippe Lagarde, Adeline Petit, Frédéric Lamare, Mathieu Hatt, Philippe Fernandez

Published in: Radiation Oncology | Issue 1/2014

Abstract

Background

The aim of this study was to assess if FDG-PET could guide dose prescription heterogeneity and decrease arbitrary location of hotspots in SBRT.

Methods

For three patients with stage I lung cancer, a CT-simulation and a FDG-PET were registered to define respectively the PTV_CT and the biological target volume (BTV). Two plans involving volumetric modulated arc therapy (VMAT) and simultaneous integrated boost (SIB) were calculated. The first plan delivered 4 × 12 Gy within the PTV_CT and the second plan, with SIB, 4 × 12 Gy and 13.8 Gy (115% of the prescribed dose) within the PTV_CT and the BTV respectively. The Dmax-PTV_CT had to be inferior to 60 Gy (125% of the prescribed dose). Plans were evaluated through the D95%, D99% and Dmax-PTV_CT, the D2 cm, the R50% and R100% and the dice similarity coefficient (DSC) between the isodose 115% and BTV. DSC allows verifying the location of the 115% isodose (ideal value = 1).

Results

The mean PTV_CT and BTV were 36.7 (±12.5) and 6.5 (±2.2) cm³ respectively. Both plans led to similar target coverage, same doses to the OARs and equivalent fall-off of the dose outside the PTV_CT. On the other hand, the location of hotspots, evaluated through the DSC, was improved for the SIB plans with a mean DSC of 0.31 and 0.45 for the first and the second plans respectively.

Conclusions

Use of PET to decrease arbitrary location of hotspots is feasible with VMAT and SIB for lung cancer.

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Title: Use of FDG-PET to guide dose prescription heterogeneity in stereotactic body radiation therapy for lung cancers with volumetric modulated arc therapy: a feasibility study
Authors: Bénédicte Henriques de Figueiredo
Mikael Antoine
Renaud Trouette
Philippe Lagarde
Adeline Petit
Frédéric Lamare
Mathieu Hatt
Philippe Fernandez
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2014
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-014-0300-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Use of FDG-PET to guide dose prescription heterogeneity in stereotactic body radiation therapy for lung cancers with volumetric modulated arc therapy: a feasibility study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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