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Open Access 01-12-2021 | Urothelial Cancer | Research

Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection

Authors: Hiroki Hagimoto, Noriyuki Makita, Yuta Mine, Hidetoshi Kokubun, Shiori Murata, Yohei Abe, Masashi Kubota, Naofumi Tsutsumi, Toshinari Yamasaki, Mutsushi Kawakita

Published in: BMC Urology | Issue 1/2021

Abstract

Background

To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT).

Methods

Between June 2018 and October 2020, 114 patients and 282 lesions were included in the analysis. Patients were orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The bladder was inspected with white light (WL), PDD, and NBI for each patient, and all areas positive by at least one method were resected or biopsied. The imaging data were then compared to the pathology results.

Results

The sensitivities of WL, PDD, and NBI for detecting urothelial carcinoma were 88.1%, 89.6%, and 76.2%, respectively. The specificity, positive predictive value, and negative predictive value for detecting urothelial carcinoma were 47.5%, 80.9%, and 61.3%, respectively, for WL; 22.5%, 74.5%, and 46.2%, respectively, for PDD; and 46.3%, 78.2%, and 43.5%, respectively, for NBI. PDD was significantly more sensitive than NBI for all lesions (p < 0.001) and carcinoma in situ (CIS) lesions (94.6% vs. 54.1%, p < 0.001).

Conclusions

PDD can increase the detection rate of bladder cancer, compared to NBI, by greater than 10%. Therefore, 100% of CIS lesions can be detected by adding PDD to WL.

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Title: Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection
Authors: Hiroki Hagimoto
Noriyuki Makita
Yuta Mine
Hidetoshi Kokubun
Shiori Murata
Yohei Abe
Masashi Kubota
Naofumi Tsutsumi
Toshinari Yamasaki
Mutsushi Kawakita
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Urothelial Cancer
Urothelial Cancer
Published in: BMC Urology / Issue 1/2021
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/s12894-021-00946-w

2024 ASCO Annual Meeting

Springer Medicine

Comparison between 5-aminolevulinic acid photodynamic diagnosis and narrow-band imaging for bladder cancer detection

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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