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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2014

Open Access 01-12-2014 | Meeting abstract

Urine with stones: nephrocalcinosis and vitamin D

Authors: Luisa Santangelo, Mario Giordano

Published in: Italian Journal of Pediatrics | Special Issue 1/2014

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Excerpt

Nephrocalcinosis (NC) refers to diffuse, fine, renal parenchymal calcification, as assessed by radiology or ultrasonography. In medullary NC, the calcification tends to occur in the area of the renal pyramids. It is typically associated with elevated urinary calcium, phosphate, and oxalate, or it can occur with alkaline urine. Any disorder that can lead to hypercalcemia or hypercalciuria may be implicated. Instead of stone formation, smaller parenchymal calcifications are deposited in the medulla, usually bilateral and symmetric. …
Literature
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Jones G, Prosser DE, Kaufmann M: 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D. Arch Biochem Biophys. 2012, 523: 9-18. 10.1016/j.abb.2011.11.003.CrossRefPubMed
2.
Schlingmann KP, Kaufmann M, Weber S, Irwin A, Goos C, John U, Misselwitz J, Klaus G, Kuwertz-Bröking E, Fehrenbach H, Wingen AM, Güran T, Hoenderop JG, Bindels RJ, Prosser DE, Jones G, Konrad M: Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med. 2011, 365: 410-421. 10.1056/NEJMoa1103864.CrossRefPubMed
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Ammenti A, Pelizzoni A, Cecconi M, Molinari PP, Montini G: Nephrocalcinosis in children: a retrospective multi-centre study. Acta Paediatr. 2009, 98: 1628-31. 10.1111/j.1651-2227.2009.01401.x.CrossRefPubMed
Metadata
Title
Urine with stones: nephrocalcinosis and vitamin D
Authors
Luisa Santangelo
Mario Giordano
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue Special Issue 1/2014
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/1824-7288-40-S1-A18

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