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Open Access 01-12-2024 | Urinary Incontinence | Research

Urinary phenols and parabens exposure in relation to urinary incontinence in the US population

Authors: Jinjiang Jiang, Bo Chen, Bo Tang, Jinze Li, Chensong Zhang, Daqing Tan, Ting Zhang, Qiang Wei

Published in: BMC Public Health | Issue 1/2024

Abstract

Background

Our study aimed to investigate the impact of urinary concentrations of personal care products (PCPs)-related phenols (PNs) and parabens (PBs), including Triclosan (TCS), Bisphenol A (BPA), Benzophenone-3 (BP-3), Butylparaben (BPB), Ethylparaben (EPB), Methylparaben (MPB), and Propylparaben (PPB), on urinary incontinence (UI) occurrence.

Method

We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2016. Regression analysis was employed to investigate the relationship between exposure to PCPs-related substances, various levels of exposure, and UI within both the general population and the female demographic. Additionally, the Bayesian Kernel Machine Regression (BKMR) model was used to assess the effects of mixtures on UI.

Results

Our analysis comprised 7,690 participants who self-reported their diagnosis. Among them, 12.80% experienced stress urinary incontinence (SUI), 11.80% reported urge urinary incontinence (UUI), and 10.22% exhibited mixed urinary incontinence (MUI). In our fully adjusted multivariable models, BP-3 exposure exhibited a positive association with SUI (OR 1.07, 95% CI 1.02–1.14, p = 0.045). BPA exposure correlated with an increased risk of UUI (OR 1.21, 95% CI 1.01–1.44, p = 0.046) and MUI (OR 1.26, 95% CI 1.02–1.54, p = 0.029). TCS exposure displayed a negative correlation with the incidence of MUI (OR 0.87, 95% CI 0.79–0.97, p = 0.009). No significant links were observed between parabens and urinary incontinence. Notably, among the female population, our investigation revealed that BPA exposure heightened the risk of MUI (OR 1.28, 95% CI 1.01–1.63, p = 0.043). Participants in the highest tertile of BP-3 exposure demonstrated elevated likelihoods of SUI and MUI compared to those in the lowest tertile. In the BKMR analysis, negative trends were observed between the mixture and the risks of UUI and MUI when the mixture ranged from the 25th to the 40th and 35th to the 40th percentiles or above, respectively. Additionally, a positive trend was identified between the mixture and MUI when it was in the 40th to 55th percentile.

Conclusion

In conclusion, our findings suggest that exposure to BPA, TCS, and BP-3 may contribute to the development of urinary incontinence.

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Title: Urinary phenols and parabens exposure in relation to urinary incontinence in the US population
Authors: Jinjiang Jiang
Bo Chen
Bo Tang
Jinze Li
Chensong Zhang
Daqing Tan
Ting Zhang
Qiang Wei
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Urinary Incontinence
Urinary Incontinence
Stress Incontinence
Published in: BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-024-17872-9

2024 ASCO Annual Meeting

Springer Medicine

Urinary phenols and parabens exposure in relation to urinary incontinence in the US population

Abstract

Background

Method

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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