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International Urogynecology Journal

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09-02-2024 | Urinary Incontinence | Original Article

Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women

Authors: David Sheyn, Hasina Momotaz, Adonis Hijaz, Oana Zeleznik, Vatche Minassian, Kathryn L. Penney

Published in: International Urogynecology Journal | Issue 3/2024

Abstract

Introduction and hypothesis

The objective of this study was to determine whether differences in the cumulative dietary intake of choline, is associated with the risk of developing urge urinary incontinence (UUI).

Methods

This was an analysis within the Nurses’ Health Study (NHS) I and II. The main exposure was the cumulative daily intake for each choline-containing compound obtained from a detailed daily food frequency questionnaire. The primary outcome was UUI, defined as urine loss with a sudden feeling of bladder fullness or when a toilet is inaccessible, occurring >1/month. Cox proportional hazards regression models were used to calculate multivariate-adjusted relative risks and 95% confidence intervals (CIs) for the association between total choline and choline derivatives and risk of UUI. Fixed effects meta-analyses of results from NHSI and NHSII were performed for postmenopausal women only to obtain a pooled estimate of the impact of choline consumption on UUI.

Results

There were 33,273 participants in NHSI and 38,732 in NHSII who met all the criteria for inclusion in the analysis. The incidence of UUI was 9.41% (n=3,139) in NHSI and 4.25% (n=1,646) in NHSII. After adjusting for confounders choline was not found to be associated with UUI in postmenopausal women. However, in premenopausal women, relative to the lowest quartile, the highest quartile of consumption of total choline (aRR = 0.79, 95% CI: 0.64–0.99), free choline (aRR = 0.74, 95% CI: 0.58–0.94), and phosphocholine (aRR = 0.77, 95% CI: 0.61–0.96) were associated with a reduced risk of UUI.

Conclusions

Increased dietary choline consumption was associated with a reduced risk of UUI among premenopausal women.

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Title: Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women
Authors: David Sheyn
Hasina Momotaz
Adonis Hijaz
Oana Zeleznik
Vatche Minassian
Kathryn L. Penney
Publication date: 09-02-2024
Publisher: Springer International Publishing
Keywords: Urinary Incontinence
Urinary Incontinence
Published in: International Urogynecology Journal / Issue 3/2024
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-024-05740-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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