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Intensive Care Medicine

Published in:

01-07-2007 | Brief Report

Urinary biomarker of oxidative stress correlating with outcome in critically septic patients

Authors: Wei-Erh Cheng, Chuen-Ming Shih, Liang-Wen Hang, Kuen-Yuh Wu, Hsin-Ling Yang, Wu-Huei Hsu, Te-Chun Hsia

Published in: Intensive Care Medicine | Issue 7/2007

Abstract

Objective

To determine whether urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), an in vivo parameter of oxidative stress, is correlated with the outcome of critically septic patients.

Design and setting

Clinical outcome study in an adult medical intensive care unit (ICU).

Patients

85 consecutive septic patients (59 men, 26 women).

Measurements and results

Patient characteristics and the clinical course were examined. Urinary 8-OHdG was analyzed using isotope-dilution liquid chromatography with tandem mass spectrometry (LC/MS/MS). ICU mortality was 25.9% (22/85) and hospital mortality 38.8% (33/85). Survivors' APACHE II scores on days 1 and 3 and the difference between them differed significantly from those of nonsurvivors (day 1, 21.0 ± 7.1 vs. 25.9 ± 8.0; day 3, 15.0 ± 5.8 vs. 23.2 ± 8.3; difference, 6.0 ± 5.5 vs. 1.7 ± 6.6). Urinary 8-OHdG was significantly lower in survivors than in nonsurvivors on day 1 (1.8 ± 2.4 vs. 3.0 ± 2.4). The area under receiver operating characteristic curve analysis for the association between day 1 urinary 8-OHdG and ICU mortality was 0.71. The comparison performed upon discharge from hospital revealed similar results.

Conclusions

This is a preliminary study. Excretion of urinary 8-OHdG, as measured using isotope-dilution LC/MS/MS, and the APACHE II score were correlated with the outcome of critically septic patients in medical ICU.

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Title: Urinary biomarker of oxidative stress correlating with outcome in critically septic patients
Authors: Wei-Erh Cheng
Chuen-Ming Shih
Liang-Wen Hang
Kuen-Yuh Wu
Hsin-Ling Yang
Wu-Huei Hsu
Te-Chun Hsia
Publication date: 01-07-2007
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 7/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0628-9

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Springer Medicine

Urinary biomarker of oxidative stress correlating with outcome in critically septic patients

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients

Measurements and results

Conclusions

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