Top

Published in:

01-06-2010 | Urology - Review

Urethral diverticular carcinoma: an overview of current trends in diagnosis and management

Authors: Kamran Ahmed, Ranan Dasgupta, Amit Vats, Kamal Nagpal, Hutan Ashrafian, Batul Kaj, Thanos Athanasiou, Prokar Dasgupta, Mohammad Shamim Khan

Published in: International Urology and Nephrology | Issue 2/2010

Abstract

Aims

To review the management of female urethral diverticular tumours, and rationalize treatment protocols.

Methods

A literature search through Medline, Psychoinfo, EMBASE and the Cochrane library from 1951 was performed for all reports and series of urethral diverticular tumours.

Results

A total of one male patient and 75 female patients were reported, with data on demographics, presentation, diagnosis, treatment modalities, recurrence rates and mortality. There is considerable variation in the method of reporting outcomes, and heterogeneity in treatment methods.

Conclusion

There appears to be no current consensus in the management of these rare tumours. There is an urgent need to establish an international registry of rare tumours to help formulate guidelines on management of such tumours. We propose a management algorithm based on the evidence gathered from review of the published literature.

Gonzalez MO, Harrison ML, Boileau MA (1985) Carcinoma in diverticulum of female urethra. Urology 26:328–332. doi:10.1016/0090-4295(85)90177-3 CrossRefPubMed

Maier U, Dorfinger K, Susani M (1998) Clear cell adenocarcinoma of the female urethra. J Urol 160:492–493. doi:10.1016/S0022-5347(01)62934-3 CrossRefPubMed

Hey H (1805) Practical observation in surgery. Humphreys, Philadelphia

Hamilton JD, Leach WB (1951) Adenocarcinoma arising in a diverticulum of the female urethra. AMA Arch Pathol 51:90–98PubMed

Rajan N, Tucci P, Mallouh C et al (1993) Carcinoma in female urethral diverticulum: case reports and review of management. J Urol 150:1911–1914PubMed

Clayton M, Siami P, Guinan P (1992) Urethral diverticular carcinoma. Cancer 70:665–670. doi:10.1002/1097-0142(19920801)70:3<665::AID-CNCR2820700321>3.0.CO;2-H CrossRefPubMed

Seballos RM, Rich RR (1995) Clear cell adenocarcinoma arising from a urethral diverticulum. J Urol 153:1914–1915. doi:10.1016/S0022-5347(01)67352-X CrossRefPubMed

Liew LC, Kesavan E, Thamboo TP et al (2003) Squamous cell carcinoma in a male urethral diverticulum. BJU Int 92(suppl. 3):e29. doi:10.1046/j.1464-410X.92.s1.6.x PubMed

Davis BL, Robinson DG (1970) Diverticula of the female urethra: assay of 120 cases. J Urol 104:850–853PubMed

10.

Shalev M, Mistry S, Kernen K et al (2002) Squamous cell carcinoma in a female urethral diverticulum. Urology 59:773. doi:10.1016/S0090-4295(02)01537-6 CrossRefPubMed

11.

Keefe B, Warshauer DM, Tucker MS et al (1991) Diverticula of the female urethra: diagnosis by endovaginal and transperineal sonography. AJR Am J Roentgenol 156:1195–1197PubMed

12.

Hickey N, Murphy J, Herschorn S (2000) Carcinoma in a urethral diverticulum: magnetic resonance imaging and sonographic appearance. Urology 55:588–589. doi:10.1016/S0090-4295(99)00584-1 CrossRefPubMed

13.

Hricak H, Secaf E, Buckley DW et al (1991) Female urethra: MR imaging. Radiology 178:527–535PubMed

14.

Neitlich JD, Foster HE Jr, Glickman MG et al (1998) Detection of urethral diverticula in women: comparison of a high resolution fast spin echo technique with double balloon urethrography. J Urol 159:408–410. doi:10.1016/S0022-5347(01)63934-X CrossRefPubMed

15.

Eilber KS, Raz S (2003) Benign cystic lesions of the vagina: a literature review. J Urol 170:717–722. doi:10.1097/01.ju.0000062543.99821.a2 CrossRefPubMed

16.

Evans KJ, McCarthy MP, Sands JP (1981) Adenocarcinoma of a female urethral diverticulum: case report and review of the literature. J Urol 126:124–126PubMed

17.

Grabstald H, Hilaris B, Henschke U et al (1966) Cancer of the female urethra. JAMA 197:835–842. doi:10.1001/jama.197.11.835 CrossRefPubMed

18.

Srinivas V, Dow D (1983) Transitional cell carcinoma in a urethral diverticulum with a calculus. J Urol 129:372–373PubMed

19.

Awakura Y, Nonomura M, Itoh N et al (2003) Adenocarcinoma of the female urethral diverticulum treated by multimodality therapy. Int J Urol 10:281–283. doi:10.1046/j.1442-2042.2003.00613.x CrossRefPubMed

20.

Davis R, Peterson AC, Lance R (2003) Clear cell adenocarcinoma in a female urethral diverticulum. Urology 61:644. doi:10.1016/S0090-4295(02)02407-X CrossRefPubMed

21.

Brown EW (1956) Diverticulum of the female urethra: report of 23 cases with adenocarcinoma in one. South Med J 49:982–988PubMed

22.

Hinman F Jr, Cohlan WR (1960) Gartner’s duct carcinoma in a urethral diverticulum. J Urol 83:414–415PubMed

23.

Wishard WN Jr, Nourse MH, Mertz JH (1963) Carcinoma in a diverticulum of the female urethra. J Urol 89:431–432PubMed

24.

Ney C, Miller HL, Ochs D (1971) Adenocarcinoma in a diverticulum of the female urethra: a case report of mucous adenocarcinoma with a summary of the literature. J Urol 106:874–877PubMed

25.

Torres SA, Quattlebaum RB (1972) Carcinoma in a urethral diverticulum. South Med J 65:1374–1376PubMed

26.

Rhamy RK, Boldus RA, Allison RC et al (1973) Therapeutic modalities in adenocarcinoma of the female urethra. J Urol 109:638–640PubMed

27.

Klotz PG (1974) Carcinoma of Skene’s gland associated with urethral diverticulum: a case report. J Urol 112:487–488PubMed

28.

Cea PC, Ward JN, Lavengood RW Jr et al (1977) Mesonephric adenocarcinomas in urethral diverticula. Urology 10:58–61. doi:10.1016/0090-4295(77)90044-9 CrossRefPubMed

29.

Marshall S, HIsrch K (1977) Carcinoma within urethral diverticula. Urology 10:161–163. doi:10.1016/0090-4295(77)90020-6 CrossRefPubMed

30.

Allen R, Nelson RP (1978) Primary urethral malignancy: review of 22 cases. South Med J 71:547–550PubMed

31.

Murayama T, Komatsu H, Asano M et al (1978) Mesonephric adenocarcinoma of the urethra in a woman: report of a case. J Urol 120:500–501PubMed

32.

Peterson LJ, Matsumoto LM (1978) Nephrogenic adenoma in urethral diverticulum. Urology 11:193–195. doi:10.1016/0090-4295(78)90109-7 CrossRefPubMed

33.

Reheis JP, Goldstein IS, Mogil RA (1981) Papillary adenocarcinoma arising in a urethral diverticulum accompanied by adenocarcinoma of the bladder: case report and review of the literature. J Urol 126:695–697PubMed

34.

Tesluk H (1981) Primary adenocarcinoma of female urethra associated with diverticula. Urology 17:197–199. doi:10.1016/0090-4295(81)90241-7 CrossRefPubMed

35.

Tanabe ET, Mazur MT, Schaeffer AJ (1982) Clear cell adenocarcinoma of the female urethra: clinical and ultrastructural study suggesting a unique neoplasm. Cancer 49:372–378. doi:10.1002/1097-0142(19820115)49:2<372::AID-CNCR2820490227>3.0.CO;2-E CrossRefPubMed

36.

Schnoy N, Leistenschneider W (1982) Tumor of mesonephric origin in a diverticulum of the urethra. An ultrastructural study. Virchows Arch A Pathol Anat Histol 397:335–345. doi:10.1007/BF00496574 CrossRefPubMed

37.

Tines SC, Bigongiari LR, Weigel JW (1982) Carcinoma in diverticulum of the female urethra. AJR Am J Roentgenol 138:582–585PubMed

38.

Patanaphan V, Prempree T, Sewchand W et al (1983) Adenocarcinoma arising in female urethral diverticulum. Urology 22:259–264. doi:10.1016/S0090-4295(83)80009-0 CrossRefPubMed

39.

Godec CJ, Anderson WR, Cass AS et al (1984) Urinary retention in female patients induced by adenocarcinoma of urethra. Urology 23:256–259. doi:10.1016/S0090-4295(84)90041-4 CrossRefPubMed

40.

Noguchi S, Ida T (1983) Carcinoma in diverticulum of female urethra—a case report and review of the literature. Hinyokika Kiyo 29:921–929PubMed

41.

Jimenez de Leon J, Luz Picazo M, Mora M et al (1989) Intra-diverticular adenocarcinoma of the urethra in women. Arch Esp Urol 42:931–935PubMed

42.

Klutke CG, Akdman EI, Brown JJ (1995) Nephrogenic adenoma arising from a urethral diverticulum: magnetic resonance features. Urology 45:323–325. doi:10.1016/0090-4295(95)80026-3 CrossRefPubMed

43.

Geisler E, Basu A, Abughaida A et al (1998) Mesonephric carcinoma arising from a female urethral diverticulum. Br J Urol 81:637–638PubMed

44.

Davis JW, Schellhammer PF, Schlossberg SM (1999) Conservative surgical therapy for penile and urethral carcinoma. Urology 53:386–392. doi:10.1016/S0090-4295(98)00483-X CrossRefPubMed

45.

Ghoniem G, Khater U, Hairston J et al (2004) Urinary retention caused by adenocarcinoma arising in recurrent urethral diverticulum. Int Urogynecol J Pelvic Floor Dysfunct 15:363–365PubMed

46.

Wishard WN Jr, Nourse MH (1952) Carcinoma in diverticulum of female urethra. J Urol 68:320–323PubMed

47.

Roth AA (1955) Carcinoma of the female urethra. Ohio Med 51:872–874PubMed

48.

Melnick JL, Birdsall TM (1960) Carcinoma of diverticulum of female urethra. Am J Obstet Gynecol 80:347–352

49.

Faulkner JW (1959) Primary carcinoma in a diverticulum of the female urethra: review of the literature and report of a case. J Urol 82:337–340PubMed

50.

Graf EC, Callahan DH, Sozer I (1962) A study of tumors of the female urethra. J Urol 88:64–70PubMed

51.

Thompson IM, Bivings FG (1962) Aspects of urethral carcinoma. J Urol 87:891–895PubMed

52.

Rosenfield LJ, Fruchtman B (1964) Carcinoma in diverticulum of the female urethra. Obstet Gynecol 24:924–927

53.

McLoughlin MG (1975) Carcinoma in situ in urethral diverticulum: pitfalls of marsupialization alone. Urology 6:343. doi:10.1016/0090-4295(75)90761-X CrossRefPubMed

54.

Bracken RB, Johnson DE, Miller LS et al (1976) Primary carcinoma of the female urethra. J Urol 116:188–192PubMed

55.

DeToledo WP, Montellato NI, Arap S et al (1978) Carcinoma in diverticulum of female urethra. Urol Int 33:393–398CrossRef

56.

Huvos AG, Muggia FM, Markewitz M (1969) Carcinoma of female urethra. Occurrence with hyperparathyroidism. N Y State J Med 69:2042–2045PubMed

57.

Oliva E, Young RH (1996) Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. Mod Pathol 9:513–520PubMed

58.

Niemiec TR, Mercer LJ, Stephens JK et al (1989) Unusual urethral diverticulum lined by colonic epithelium with Paneth cell metaplasia. Am J Obstet Gynecol 160:186–188PubMed

Title: Urethral diverticular carcinoma: an overview of current trends in diagnosis and management
Authors: Kamran Ahmed
Ranan Dasgupta
Amit Vats
Kamal Nagpal
Hutan Ashrafian
Batul Kaj
Thanos Athanasiou
Prokar Dasgupta
Mohammad Shamim Khan
Publication date: 01-06-2010
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 2/2010
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-009-9618-x

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aims

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 2/2010

Body mass index modulates postural proteinuria

Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis

Association of macroalbuminuria with oxidized LDL and TGF-β in type 2 diabetic patients: a case–control study

Group session teaching of behavioral modification program (BMP) for urinary incontinence: a randomized controlled trial among incontinent women

Clinicopathological study of infection-associated glomerulonephritis in adults

The clearance of unidentified uremic solutes (with molecular weight under 5 kDa) plays an important role in hemodialyzer selection

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials