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International Urology and Nephrology

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Open Access 30-10-2023 | Ureterorenoscopy | Urology - Original Paper

Does preoperative silodosin administration facilitate ureteral dilatation during flexible ureterorenoscopy? A randomized clinical trial

Authors: Tamer Diab, Waleed El-Shaer, Saad Ibrahim, Ehab El-Barky, Ahmed Abou Elezz

Published in: International Urology and Nephrology | Issue 3/2024

Abstract

Purpose

To assess whether preoperative administration of silodosin can facilitate the placement of ureteral access sheath (UAS) prior to flexible ureteroscopy (F-URS) and reduce the occurrence of ureteric injury in challenging cases.

Methods

This prospective randomized clinical trial was carried out on 147 patients diagnosed with upper ureteric stone or stone kidney, non-stented. The patients were randomly divided into two equal groups. Group A (silodosin group) included patients in whom F-URS was done with daily preoperative intake of 8 mg silodosin for 1 week and group B (placebo/control group) included patients in whom F-URS was done with daily preoperative intake of placebo tablets.

Results

In group A, a total of 23 (33.3%) experienced ureteral wall injury following UAS insertion, while in group B, this occurred in 40 patients (59.7%). There was a statistically significant difference in the grade of ureteral wall injury between the two groups (P < 0.001). In the multiple regression analysis, age, operative time and silodosin were found to be significant risk factors for ureteral wall injury (P = 0.007, 0.041 and < 0.001, respectively).

Conclusions

The administration of silodosin prior to retrograde intrarenal surgery (RIRS) effectively prevented significant ureteral wall damage and reduced initial postoperative discomfort.

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Title: Does preoperative silodosin administration facilitate ureteral dilatation during flexible ureterorenoscopy? A randomized clinical trial
Authors: Tamer Diab
Waleed El-Shaer
Saad Ibrahim
Ehab El-Barky
Ahmed Abou Elezz
Publication date: 30-10-2023
Publisher: Springer Netherlands
Keyword: Ureterorenoscopy
Published in: International Urology and Nephrology / Issue 3/2024
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-023-03824-6

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