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Obesity Surgery

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01-04-2016 | Brief Communication

Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy

Authors: Feng Li, Han Cao, Chunjun Sheng, Hang Sun, Kexiu Song, Shen Qu

Published in: Obesity Surgery | Issue 4/2016

Abstract

Purpose

Sleeve gastrectomy is an effective technique for the treatment of severe obesity, and its effects on the improved β-cell function have not yet been fully understood.

Materials and Methods

From February 2014 to July 2015, sleeve gastrectomy was performed in 5 patients with T2D, who were assessed before and after sleeve gastrectomy (SG). Moreover, a high-fat-diet (HFD) mouse model was also used to study the molecular mechanisms of β-cell functional improvement after SG.

Results

The glucose-stimulated acute insulin response was restored in the T2D patients after SG. The expression of GLP-1 in colonic tissue as well as β-cell specific transcription factors (TFs), Pdx1, and MafA in islets was significantly increased after SG.

Conclusion

β-cell dysfunction can be ameliorated by SG. The re-activation of key TFs contributes to the improvement of β cell function.

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Title: Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy
Authors: Feng Li
Han Cao
Chunjun Sheng
Hang Sun
Kexiu Song
Shen Qu
Publication date: 01-04-2016
Publisher: Springer US
Published in: Obesity Surgery / Issue 4/2016
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-016-2068-5

At a glance: The STEP trials

Springer Medicine

Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy

Abstract

Purpose

Materials and Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusion

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