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Open Access 01-12-2013 | Research article

Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

Authors: Rachel C Dirks, Jeffrey S Richard, Angela M Fearon, Alexander Scott, Lauren G Koch, Steven L Britton, Stuart J Warden

Published in: BMC Musculoskeletal Disorders | Issue 1/2013

Abstract

Background

The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.

Methods

Twenty-six mature rats selectively bred for high-capacity running were divided into run and cage control groups. Run group rats ran on a treadmill at a 15° incline for a maximum duration of 1 hr/d, 5 d/wk for 9 weeks at increasing speeds, while rats in the cage control group maintained normal cage activity. After 9 weeks, Achilles tendons were harvested for histological processing and semi-quantitative histopathological analysis.

Results

There were no significant group differences within each of the individual histopathological categories assessed (all p ≥ 0.16) or for total histopathological score (p = 0.14).

Conclusions

Uphill treadmill running in rats selectively bred for high-capacity running did not generate Achilles tendon changes consistent with the histopathological presentation of Achilles tendinosis in humans.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/14/90/prepub

Title: Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon
Authors: Rachel C Dirks
Jeffrey S Richard
Angela M Fearon
Alexander Scott
Lauren G Koch
Steven L Britton
Stuart J Warden
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: BMC Musculoskeletal Disorders / Issue 1/2013
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/1471-2474-14-90

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Uphill treadmill running does not induce histopathological changes in the rat Achilles tendon

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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