Top

Published in:

Open Access 01-06-2009 | Meeting abstract

Update of recent studies in chronic myeloid leukemia

Author: Karen Seiter

Published in: Journal of Hematology & Oncology | Special Issue 1/2009

Excerpt

The use of tyrosine kinase inhibitors (TKIs) has dramatically improved outcomes for patients with chronic myeloid leukemia (CML). The IRIS study is the definitive phase III trial of imatinib mesylate as frontline therapy for CML. Seven year follow-up data has recently been reported [1]. The overall survival (including deaths from all causes) is 86% and the event free survival is 81% at seven years. Seven percent of patients have progressed to accelerated or blastic phase, with the highest risk being in the second year of treatment. Eighty-two percent of patients have achieved complete cytogenetic remission (CCyR) and 83% of these patients maintain that remission. Of the patients that discontinued study, 8% were for toxicity, 15% for efficacy and 17% for other reasons. …

O'Brien SG, Guilhot F, Goldman JM, Hochhaus A, Hughes TP, Radich JP, Rudoltz M, Filian J, Gathmann I, Druker BJ, Larson RA: International Randomized Study of Interferon Versus STI571 (IRIS) 7-Year Follow-up: Sustained Survival, Low Rate of Transformation and Increased Rate of Major Molecular Response (MMR) in Patients (pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CMLCP) Treated with Imatinib (IM). Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 186

Cortes J, Baccarani M, Guilhot F, Druker BJ, Branford S, Kim DW, Pane F, Rudoltz M, Yu R, Collins LT, Krahnke T, Radich JP, Hughes TP: A Phase III, Randomized, Open-Label Study of 400 Mg Versus 800 Mg of Imatinib Mesylate (IM) in Patients (pts) with Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Using Molecular Endpoints: 1-Year Results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) Study. Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 335

Petzer AL, Wolf D, Fong D, Lion T, Dyagil I, Masliak Z, Boskovic D, Griskevicius L, Lejniece S, Goranov S, Gercheva L, Stojanovic A, Peytchev D, Tzvetkov N, Griniute R, Oucheva R, Ulmer H, Kwakkelstein M, Fincato G, Gastl G: CELSG CML 11 "ISTAHIT" Phase III Study – Planned Interim Analysis: High Doses of Imatinib Mesylate (800 mg/day) Significantly Improve Rates of Major and Complete Cytogenetic Remissions (MCR, CCR) in Pretreated Ph⁺/BCR-ABL⁺ CML Patients in Chronic Phase. Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 1112

Baccarani M, Castagnetti F, Porkka K, Nielsen JL, Hjorth-Hansen H, Haznedaroglu I, Nagler A, Rege-Cambrin G, Specchia G, Amabile M, Testoni N, Palandri F, Pane F, Alimena G, Martinelli G, Rosti G, Simonsson B: A Prospective Study of Imatinib 400 mg vs 800 mg Frontline in High Risk Ph+ Chronic Myeloid Leukemia (CML) Patients. Blood (ASH Annual Meeting Abstracts). 2007, 110: Abstract 26

Müller MC, Hanfstein B, Erben P, Schnittger S, Saussele S, Leitner A, Proetel U, Lauseker M, Pfirrmann M, Ehninger G, Fischer T, Hasford J, Hossfeld DK, Kolb HJ, Krause SW, Nerl C, Pralle H, Gratwohl A, Tobler A, Hehlmann R, Hochhaus A, The German CML Study Group: Molecular Response to First Line Imatinib Therapy Is Predictive for Long Term Event Free Survival in Patients with Chronic Phase Chronic Myelogenous Leukemia – An Interim Analysis of the Randomized German CML Study IV. Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 333

Branford S, Lawrence R, Grigg A, Seymour JF, Schwarer A, Arthur C, Rudzki Z, Hughes T: Long Term Follow up of Patients with CML in Chronic Phase Treated with First-Line Imatinib Suggests That Earlier Achievement of a Major Molecular Response Leads to Greater Stability of Response. Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 2113

Guilhot F, Mahon FX, Guilhot J, Rigual-Huguet F, Maloisel F, Rousselot P, Gardembas M, Corm S, Guerci A, Vekhoff A, Etienne G, Legros L, Kiladjian JJ, Jourdan E, Schoenwald E, Berger M, Eclache V, Roche-Lestienne C, Nicolini FE, Preudhomme C: Randomized Comparison of Imatinib Versus Imatinib Combination Therapies in Newly Diagnosed Chronic Myeloid Leukaemia (CML) Patients in Chronic Phase (CP): First Results of the Phase III (SPIRIT) Trial from the French CML Group (FI LMC). Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 183

Cortes J, O'Brien S, Jones D, Ferrajoli A, Konopleva M, Borthakur G, Garcia-Manero G, Letvak LA, Kantarjian H: Efficacy of Nilotinib (formerly AMN107) in Patients (Pts) with Newly Diagnosed, Previously Untreated Philadelphia Chromosome (Ph)-Positive Chronic Myelogenous Leukemia in Early Chronic Phase (CML-CP). Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 446

Cortes J, O'Brien S, Jones D, Borthakur G, Giles F, Nicaise C, Kantarjian HM: Dasatinib (SPRYCEL^®) in Patients (pts) with Previously Untreated Chronic Myelogenous Leukemia (CML) in Chronic Phase (CML-CP). Blood (ASH Annual Meeting Abstracts). 2006, 108: Abstract 2161

10.

Mahon FX, Huguet F, Guilhot F, Legros L, Nicolini FE, Charbonnier A, Guerci A, Rea D, Varet BR, Gardembas M, Guilhot J, Etienne G, Milpied NJ, Aton E, Reiffers J, Rousselot P: Is It Possible to Stop Imatinib in Patients with Chronic Myeloid Leukemia? An Update from a French Pilot Study and First Results from the Multicentre «Stop Imatinib» (STIM) Study. Blood. 2008, 112: Abstract 187

11.

Cortes J, Bruemmendorf T, Kantarjian H, Khoury J, Rosti G, Fischer T, Tornaghi L, Hewes B, Martin EC, Gambacorti-Passerini C: Efficacy and Safety of Bosutinib (SKI-606) among Patients with Chronic Phase Ph+ Chronic Myelogenous Leukemia (CML). Blood (ASH Annual Meeting Abstracts). 2007, 110: Abstract 733

12.

Cortes J, Khoury HJ, Corm S, Nicolini FE, Lipton JH, Jones D, Hochhaus A, Craig AR, Benichou AC, Humphriss E, Kantarjian H: Safety and Efficacy of Subcutaneous (SC) Omacetaxine Mepesuccinate in Imatinib(IM)-Resistant Chronic Myeloid Leukemia (CML) Patients (pts) with the T315I Mutation – Results of An Ongoing Multicenter Phase II Study. Blood (ASH Annual Meeting Abstracts). 2008, 112: Abstract 3239

Title: Update of recent studies in chronic myeloid leukemia
Author: Karen Seiter
Publication date: 01-06-2009
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue Special Issue 1/2009
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/1756-8722-2-S1-A2

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 1/2009

What's new in the management of chronic lymphocytic leukemia? 2008 ASH Review (New York Medical College, January 31, 2009)

Molecular target therapy – towards curative regimen: a 20-year experience in the treatment of acute promyelocytic leukemia (APL) in the Shanghai Institute of Hematology

Recent progress in the treatment of multiple myeloma: updates and highlights from ASH 2008

New insights on low-grade and T-cell lymphoma

Update on chronic immune thrombocytopenic purpura (ITP)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer