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Journal of Cancer Research and Clinical Oncology
Published in: Journal of Cancer Research and Clinical Oncology 4/2024

Open Access 01-04-2024 | Review

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Authors: Sara Abdolmaleki, Alireza Aliabadi, Samad Khaksar

Published in: Journal of Cancer Research and Clinical Oncology | Issue 4/2024

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Abstract

Copper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in various cancers, including locally advanced rectal cancer and bulky tumors. Several studies have shown that copper nanoparticles can be used as effective agents in chemodynamic therapy, phototherapy, hyperthermia, and immunotherapy. Despite the promising anticancer activity of copper-based compounds, their use in clinical trials is subject to certain limitations. Elevated copper concentrations may promote tumor growth, angiogenesis, and metastasis by affecting cellular processes.
Literature
Abdolmaleki S, Ghadermazi M (2017) Novel pyridinedicarboxamide derivatives and a polymeric copper (II) complex: synthesis, structural characterization, electrochemical behavior, catalytic and cytotoxic studies. Inorg Chim Acta 461:221
Abdolmaleki S, Ghadermazi M, Fattahi A, Sheshmani S (2016) Synthesis, characterization, spectral studies and cytotoxic effects of mixed-ligand mono and binuclear copper (II) complexes and their amide ligands. Inorg Chim Acta 443:284
Abdolmaleki S, Ghadermazi M, Fattahi A, Shokraii S, Alimoradi M, Shahbazi B, Judy Azar AR (2017) Synthesis, crystallographic and spectroscopic studies, evaluation as antimicrobial and cytotoxic agents of a novel mixed-ligand nickel (II) complex. J Coord Chem 70:1406
Abdolmaleki S, Ghadermazi M, Ashengroph M, Saffari A, Sabzkohi SM (2018) Cobalt (II), zirconium (IV), calcium (II) complexes with dipicolinic acid and imidazole derivatives: X-ray studies, thermal analyses, evaluation as in vitro antibacterial and cytotoxic agents. Inorg Chim Acta 480:70
Abdolmaleki S, Yarmohammad N, Adibi H, Ghadermazi M, Ashengroph M, Amiri Rudbari H, Brunoe G (2019) X-ray studies, electrochemical properties, evaluation as in vitro cytotoxic and antibacterial agents of two antimony (III) complexes with dipicolinic acid. Polyhedron 159:239
Abdolmaleki S, Ghadermazi M, Bagheri F, Rudbari HA, Bruno G (2020) Evaluation of two novel macrocycles containing pyridine-2, 6-dicarboxamide unit as cationic fluorescent sensor. Polyhedron 176:114292
Abdolmaleki S, Ghadermazia M, Aliabadi A (2021a) Study on electrochemical behavior and in vitro anticancer effect of Co (II) and Zn (II) complexes containing pyridine-2, 6-dicarboxylate. Inorg Chim Acta 527:120549
Abdolmaleki S, Ghadermazi M, Aliabadi A (2021b) Novel Tl (III) complexes containing pyridine-2, 6-dicarboxylate derivatives with selective anticancer activity through inducing mitochondria-mediated apoptosis in A375 cells. Sci Rep 11:1
Abdolmaleki S, Aliabadi A, Ghadermazi M (2022a) Two La (III) complexes containing pyridine-2, 6-dicarboxylate as in vitro potent cytotoxic agents toward human lymphocyte cells. Inorg Chim Acta 542:121152
Abdolmaleki S, Aslani A, Aliabadi A, Khazayel S, Amininasab SM, Izadi Z, Ghadermazi M, Motieiyan E, Marabello D, Hugo Nunes Rodrigues V (2022b) Study on a Ru (III) complex containing picolinate with potent inhibition effect against melanoma cell line. J Coord Chem 75:147
Abdolmaleki S, Panjehpour A, Khaksar S, Ghadermazi M, Rostamnia S (2023a) Evaluation of central-metal effect on anticancer activity and mechanism of action of isostructural Cu (II) and Ni (II) complexes containing pyridine-2, 6-dicarboxylate. Eur J Med Chem 245:114897PubMed
Abdolmaleki S, Khaksar S, Aliabadi A, Panjehpour A, Motieiyan E, Marabello D, Faraji MH, Beihaghi M (2023b) Cytotoxicity and mechanism of action of metal complexes: an overview. Toxicology 492:153516PubMed
Abu-Serie MM, Abdelfattah EZ (2023) A comparative study of smart nanoformulations of diethyldithiocarbamate with Cu4O3 nanoparticles or zinc oxide nanoparticles for efficient eradication of metastatic breast cancer. Sci Rep 13:3529PubMedPubMedCentral
Adibi H, Abdolmaleki S, Shahabadi N, Golabi A, Mahdavi M, Zendehcheshm S, Ghadermazi M, Ansari M, Amiri Rudbari H, Bruno G, Nemati A (2019) Investigation of crystallographic structure, in vitro cytotoxicity and DNA interaction of two La (III) and Ce (IV) complexes containing dipicolinic acid and 4-dimethylaminopyridine. Polyhedron 163:20
Adsule S, Barve V, Chen D, Ahmed F, Dou QP, Padhye S, Sarkar FH (2006) Novel schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells. J Med Chem 49:7242PubMed
Ahmed F, Adsule S, Ali AS, Banerjee S, Ali S, Kulkarni S, Padhye S, Sarkar FH (2007) A novel copper complex of 3-benzoylalpha methyl benzene acetic acid with antitumor activity mediated via cyclooxygenase pathway. Int J Cancer 120:734PubMed
Aishajiang R, Liu Z, Wang T, Zhou L, Yu D (2023a) Recent advances in cancer therapeutic copper-based nanomaterials for antitumor therapy. Molecules 28:2303PubMedPubMedCentral
Alem MB, Damena T, Desalegn T, Koobotse M, Eswaramoorthy R, Ngwira KJ, Ombito JO, Zachariah M, Demissie TB (2022) Cytotoxic mixed-ligand complexes of Cu (II): a combined experimental and computational study. Front Chem 10:1028957PubMedPubMedCentral
Al-Fakeh MS, Messaoudi S, Alresheedi FI, Albadri AE, El-Sayed WA, Saleh EE (2023) Preparation, characterization, DFT calculations, antibacterial and molecular docking study of Co (II), Cu (II), and Zn (II) mixed ligand complexes. Crystals 13:118
Aliabadi A, Motieiyan E, Hosseinabadi F, Ghadermazi M, Abdolmaleki S (2021a) One-pot synthesis, crystallographic characterization, evaluation as in vitro antibacterial and cytotoxic agents of two mercury (II) complexes containing pyridine dicarboxylic acid derivatives. J Mol Struct 1226:129405
Aliabadi A, Hakimi M, Hosseinabadi F, Motieiyan E, Hugo Nunes Rodrigues V, Ghadermazid M, Marabello D, Abdolmaleki S (2021b) Investigation of X-ray crystal structure and in vitro cytotoxicity of two Ga (III) complexes containing pyridine dicarboxylic acid derivatives and 2-aminobenzimidazole. J Mol Struct 1223:129005
Aliabadi A, Zangeneh M, Izadi Z, Badzohre M, Ghadermazi M, Marabello D, Bagheri F, Farokhi A, Motieiyan E, Abdolmaleki S (2022) Green synthesis, X-ray crystal structure, evaluation as in vitro cytotoxic and antibacterial agents of a new Zn (II) complex containing dipicolinic acid. J Mol Struct 1247:131327
Amatya R, Lee D, Sultana M, Min KA, Shin MC (2023) Albumin-coated copper nanoparticles for photothermal cancer therapy: synthesis and in vitro characterization. Heliyon 9:e17732PubMedPubMedCentral
Ambike V, Adsule S, Ahmed F, Wang Z, Afrasiabi Z, Sinn E, Sarkar F, Padhye S (2007) Copper conjugates of nimesulide Schiff bases targeting VEGF, COX and Bcl-2 in pancreatic cancer cells. J Inorg Biochem 101:1517PubMed
Atakul T, Altinkaya SO, Abas BI, Yenisey C (2020) Serum copper and zinc levels in patients with endometrial cancer. Biol Trace Elem Res 195:46PubMed
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J et al (2020) Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nat Commun 11:3701PubMedPubMedCentral
Baldini M, Belicchi-Ferrari M, Bisceglie F, Dall’Aglio PP, Pelosi G, Pinelli S, Tarasconi P (2004) Copper(II) complexes with substituted thiosemicarbazones of alpha-Ketoglutaric acid: synthesis, X-ray structures, DNA binding studies, and nuclease and biological activity. Inorg Chem 43:7170PubMed
Beckford FA, Webb KR (2017) Copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: antimicrobial and biophysical properties. Spectrochim Acta Part A Mol Biomol Spect 183:158
Bestwick CS, Milne L, Pirie L, Duthie SJ (2005) The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells. Biochim Biophys Acta Mol Basis Dis 1740:340
Bisaglia M, Bubacco L (2020) Copper Ions and Parkinson’s disease: why is homeostasis so relevant? Biomolecules 10:195PubMedPubMedCentral
Cai X, Pan N, Zou G (2007) Copper-1,10-phenanthroline-induced apoptosis in liver carcinoma Bel-7402 cells associates with copper overload, reactive oxygen species production, glutathione depletion and oxidative DNA damage. Biometals 20:1PubMed
Cai DH, Zhang CL, Liu QY, He L, Liu YJ, Xiong YH, Le XY (2021) Synthesis, DNA binding, antibacterial and anticancer properties of two novel water-soluble copper (II) complexes containing gluconate. Eur J Med Chem 213:113182PubMed
Cantiello F, Crocerossa F, Cascini GL, Russo GI, Ferro M, Cimino S, Lucarelli F, Damiano R (2021) 64CuCl2 PET/CT as a potential new imaging method in prostate cancer: illusion or reality? Minerva Urol, Nephrol 73:668PubMed
Capasso G, Durzu A, Piras S, Zandieh S, Knoll P, Haug A (2015) Role of 64CuCl2 PET/CT in staging of prostate cancer. Ann Nucl Med 6:482
Capriotti G, Piccardo A, Giovannelli E, Signore A (2022) Targeting copper in cancer imaging and therapy: a new theragnostic agent. J Clin Med 12:223PubMedPubMedCentral
Ceramella J, Mariconda A, Iacopetta D, Saturnino C, Barbarossa A, Caruso A, Rosano C, Sinicropi MS, Longo P (2020) From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases. Bioorg Med Chem Lett 30:126905PubMed
Cerchiaro G, Aquilano K, Filomeni G, Rotilio G, Ciriolo MR, Ferreira AMDC (2005) Isatin-Schiff base copper(II) complexes and their influence on cellular viability. J Inorg Biochem 99:1433PubMed
Chen X, Zhang X, Chen J, Yang Q, Yang L, Xu D, Zhang P, Wang X, Liu J (2017) Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells. Eur J Pharmacol 815:147–155PubMed
Chen C, Ma Y, Du S, Wu Y, Shen P, Yan T, Li X, Song Y, Zha Z, Han X (2021) Controlled CRISPR-Cas9 ribonucleoprotein delivery for sensitized photothermal therapy. Small 17:e2101155PubMed
Chen X, Liu J, Li Y, Pandey NK, Chen T, Wang L, Amador EH, Chen W, Liu F, Xiao E et al (2022) Study of copper-cysteamine based X-ray induced photodynamic therapy and its effects on cancer cell proliferation and migration in a clinical mimic setting. Bioact Mater 7:504PubMed
Cheng Q, Li Y, Huang W, Li K, Lan M, Wang B, Wang J, Song X (2023) Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy. Chem Commun 59:5886
Cheung EC, Vousden KH (2022) The role of ROS in tumor development and progression. Nat Rev Cancer 22:280PubMed
Climova A, Pivovarova E, Szczesio M, Gobis K, Ziembicka D, Korga-Plewko A, Kubik J, Iwan M, Antos-Bielska M, Krzyżowska M, Czylkowska A (2023) Anticancer and antimicrobial activity of new copper (II) complexes. J Inorg Biochem 240:112108PubMed
Cui R, Li B, Liao C, Zhang S (2023) Copper-mediated chemodynamic therapy with ultra-low copper consumption by doping cupric ion on cross-linked (R)-(+)-lipoic acid nanoparticles. Regen. Biomater. 10:021
Dallavalle F, Gaccioli F, Franchi-Gazzola R, Lanfranchi M, Marchio L, Pellinghelli MA, Tegoni M (2002) Synthesis, molecular structure, solution equilibrium, and antiproliferative activity of thioxotriazoline and thioxotriazole complexes of copper(II) and palladium(II). J Inorg Biochem 92:95PubMed
Datta NR, Ordonez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S (2015) Local hyperthermia combined with radiotherapy and/or chemotherapy: Recent advances and promises for the future. Cancer Treat Rev 41:742PubMed
de Hoog P, Boldron C, Gamez P, Sliedregt-Bol K, Roland I, Pitie M, Kiss R, Meunier B, Reedijk J (2007) New approach for the preparation of efficient DNA cleaving agents: ditopic copper-platinum complexes based on 3-clip-phen and cisplatin. J Med Chem 50:3148PubMed
Deegan C, Coyle B, McCann M, Devereux M, Egan DA (2006) In vitro anti-tumor effect of 1,10-phenanthroline-5,6-dione (phendione), [Cu(phendione)3](ClO4)2·4H2O and [Ag(phendione)2]ClO4 using human epithelial cell lines. Chemico-Biol Interact 164:115
Deegan C, McCann M, Devereux M, Coyle B, Egan D (2007a) In vitro cancer chemotherapeutic activity of 1,10-phenanthroline(phen), [Ag2(phen)3(mal)].2H2O, [Cu(phen)2(mal)].2H2O and [Mn(phen)2(mal)].2H2O (malH2 = malonic acid) using human cancer cells. Cancer Lett 247:224PubMed
Deegan C, McCann M, Devereux M, Coyle B, Egan DA (2007b) In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)].2H2O, [Cu(phen)2(mal)].2H2O and [Mn(phen)2(mal)].2H2O (malH2 = malonic acid) using human cancer cells. Cancer Lett 247:224PubMed
Del Bello F, Pellei M, Bagnarelli L, Santini C, Giorgioni G, Piergentili A, Quaglia W, Battocchio C, Iucci G, Schiesaro I, Meneghini C (2022) Cu (I) and Cu (II) complexes based on lonidamine-conjugated ligands designed to promote synergistic antitumor effects. Inorg Chem 61:4919PubMedPubMedCentral
Devereux M, McCann M, Shea DO, Kelly R, Egan D, Deegan C, Kavanagh K, McKee V, Finn G (2004) Synthesis, antimicrobial activity and chemotherapeutic potential of inorganic derivatives of 2-(4’-thiazolyl)benzimidazole{thiabendazole}: X-ray crystal structures of [Cu(TBZH)2Cl]Cl.H2O.EtOH and TBZH2NO3 (TBZH = thiabendazole). J Inorg Biochem 98:1023PubMed
Devereux M, O’Shea D, O’Connor M, Grehan H, Connor G, McCann M, Rosair G, Lyng F, Kellett A, Walsh M, Egan D, Thati B (2007) Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)2(bipy)(H2O)], [Cu(SalH)2(BZDH)2], and [Cu(CH3COO)2(5,6-DMBZDH)2] (SalH2 = salicylic acid; BZAH = benzoic acid; BZDH = benzimidazole and 5,6-DMBZDH = 5,6-dimethylbenzimidazole). Polyhedron 26:4073
Elkanzi NA, Hrichi H, Salah H, Albqmi M, Ali AM, Abdou A (2023) Synthesis, physicochemical properties, biological, molecular docking and DFT investigation of Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) complexes of the 4-[(5-oxo-4, 5-dihydro-1, 3-thiazol-2-yl) hydrazono] methyl} phenyl 4-methylbenzenesulfonate Schiff-base ligand. Polyhedron 230:116219
Evans CW, Atkins C, Pathak A, Gilbert BE, Noah JW (2015) Benzimidazole analogs inhibit respiratory syncytial virus G protein function. Antivir Res 121:31PubMed
Falcone E, Stellato F, Vileno B, Bouraguba M, Lebrun V, Ilbert M, Morante S, Faller P (2023) Revisiting the pro-oxidant activity of copper: interplay of ascorbate, cysteine and glutathione. Metallomics 15:mfad040PubMedPubMedCentral
Fan K, Dong Y, Li T, Li Y (2022) Cuproptosis-associated CDKN2A is targeted by plicamycin to regulate the microenvironment in patients with head and neck squamous cell carcinoma. Front Genet 13:1036408PubMed
Fang A-P, Chen P-Y, Wang X-Y, Liu Z-Y, Zhang D-M, Luo Y et al (2019) Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the guangdong liver cancer cohort. Int J Cancer 144:2823PubMed
Feng W, Ye F, Xue W, Zhou Z, Kang YJ (2009) Copper regulation of hypoxia-inducible factor-1 activity. Mol Pharmacol 75:174PubMed
Feng LC, Zhang J, Dou L, Dong WK (2023) Synthesis, structure, theoretical studies, and fluorescence properties of two multinuclear Cu (II) bis (salamo)-like complexes. J Coord Chem 76:648
Fernández CY, Alvarez N, Rocha A, Ellena J, Costa-Filho AJ, Batista AA, Facchin G (2023) New Copper (II)-L-dipeptide-bathophenanthroline complexes as potential anticancer agents—synthesis, characterization and cytotoxicity studies—and comparative DNA-binding study of related phen complexes. Molecules 28:896PubMedPubMedCentral
Ferrari MB, Gasparri Fava F, Tarasconi P, Albertini R, Pinelli S, Starcich R (1994) Synthesis, spectroscopic and structural characterization, and biological activity of aquachloro(pyridoxal thiosemicarbazone)copper(II) chloride. J Inorg Biochem 53:13
Ferrari MB, Fava GG, Leporati E, Pelosi G, Rossi R, Tarasconi P, Albertini R, Bonati A, Lunghi P, Pinelli S (1998) Synthesis, characterization and biological activity of three copper(II) complexes with a modified nitrogenous base: 5-formyluracil thiosemicarbazone. J Inorg Biochem 70:145PubMed
Ferrari MB, Capacchi S, Pelosi G, Reffo G, Tarasconi P, Albertini R, Pinelli S, Lunghi P (1999) Synthesis, structural characterization and biological activity of helicin thiosemicarbazone monohydrate and a copper(II) complex of salicylaldehyde thiosemicarbazone. Inorg Chim Acta 286:134
Ferrari MB, Bisceglie F, Leporati E, Pelosi G, Tarasconi P (2002) Synthesis, solution chemistry, x-ray structure and biological activity of novel pyridoxal thiosemicarbazone derivatives. Bull Chem Soc Jpn 75:781
Fiadjoe HK, Lambring C, Sankpal UT, Alajroush D, Holder AA, Basha R (2023) Anti-proliferative effect of two copper complexes against medulloblastoma cells. Cancer Res 83:1538
Filomeni G, Cerchiaro G, Da Costa Ferreira AM, De Martino A, Pedersen JZ, Rotilio G, Ciriolo MR (2007a) Pro-apoptotic activity of novel isatin-schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage. J Biol Chem 282:12010PubMed
Fiz F, Bottoni G, Ugolini M, Righi S, Cirone A, Garganese MC, Verrico A, Rossi A (2022) Diagnostic and dosimetry features of [64Cu]CuCl2 in high-grade paediatric infiltrative gliomas. Mol Imaging Biol 25:391PubMed
Gajare SP, Bansode PA, Patil PV, Aalhusaini TN, Chavan SS, Pore DM, Chhowala TN, Khot VM, Rashinkar GS (2022) Nano-magnetic copper complexes as double-edged sword against MCF-7 breast cancer cells. Chem Select 7:e202103818
Gandin V, Pellei M, Tisato F, Porchia M, Santini C, Marzano C (2012) A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signaling. J Cell Mol Med 16:142PubMed
Gandin V, Tisato F, Dolmella A, Pellei M, Santini C, Giorgetti M, Marzano C, Porchia M (2014) In vitro and in vivo anticancer activity of copper (I) complexes with homoscorpionate tridentate tris (pyrazolyl) borate and auxiliary monodentate phosphine ligands. J Med Chem 57:2014
García-Pérez FO, Medina-Ornelas SS, Barron-Barron F, Arrieta-Rodriguez O (2020) Evaluation of non-small cell lung cancer by PET/CT with 64CuCl2: initial experience in humans. Am J Nucl Med Mol Imaging 10:143PubMedPubMedCentral
Geraki K, Farquharson MJ, Bradley DA (2002) Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study. Phys Med Biol 47:2327PubMed
Ghaleh HEG, Zarei L, Mansori Motlagh B, Jabbari N (2019) Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy. Artif Cells Nanomed Biotechnol. 47:1396
Gomathi R, Andy R (2013) Synthesis, Characterization of novel Cu(II) complexes of isatin derivatives as potential cytotoxicity DNA binding, cleavage and antibacterial agents. Intl J Innov Res Sci Eng Techn 2:4852
Graur V, Usataia I, Graur I, Garbuz O, Bourosh P, Kravtsov V, Lozan-Tirsu C, Balan G, Fala V, Gulea A (2023) Novel Copper (II) complexes with N 4, S-diallylisothiosemicarbazones as potential antibacterial/anticancer drugs. Inorganics 11:195
Gu J, Chen F, Zheng Z, Bi L, Morovvati H, Goorani S (2023) Novel green formulation of copper nanoparticles by Foeniculum vulgare: chemical characterization and determination of cytotoxicity, anti-human lung cancer and antioxidant effects. Inorg Chem Commun 150:110442
Guan D, Zhao L, Shi X, Ma X, Chen Z (2023) Copper in cancer: from pathogenesis to therapy. Biomed Pharmacother 63:114791
Guerreiro JF, Alves V, Abrunhosa AJ, Paulo A, Gil OM, Mendes F (2018) Radiobiological characterization of 64CuCl2 as a simple tool for prostate cancer theranostics. Molecules 23:2944PubMedPubMedCentral
Gul NS, Khan TM, Chen M, Huang KB, Hou C, Choudhary MI, Liang H, Chen ZF (2020) New copper complexes inducing bimodal death through apoptosis and autophagy in A549 cancer cells. J Inorg Biochem 213:111260PubMed
Guo Z, Zhou X, Hou C, Ding Z, Wen C, Zhang L-J, Jiang B-P, Shen X-C (2019) A chloroplast-inspired nanoplatform for targeting cancer and synergistic photodynamic/photothermal therapy. Biomater Sci 7:3886PubMed
Guo Y, Fan Y, Wang Z, Li G, Zhan M, Gong J, Majoral JP, Shi X, Shen M (2022) Chemotherapy mediated by biomimetic polymeric nanoparticles potentiates enhanced tumor immunotherapy via amplification of endoplasmic reticulum stress and mitochondrial dysfunction. Adv Mater 34:2206861
Ha JW, Choi JY, Boo YC (2023) Differential effects of histidine and histidinamide versus cysteine and cysteinamide on copper ion-induced oxidative stress and cytotoxicity in HaCaT keratinocytes. Antioxidants 12:801PubMedPubMedCentral
Habib NS, Rida SM, Badawey EA, Fahmy HT, Ghozlan HA (1997) Synthesis and biological investigations of some novel thiazolylbenzimidazoles, and benzimidazolyl-thiazolo[4,5-d]pyrimidines. Pharmazie 52:346PubMed
Han J (2023) Copper trafficking system in cells: insights into coordination chemistry and toxicity. Dalton Trans 52:15277PubMed
Hanson S, Dharan A, Pv J, Pal S, Nair BG, Kar R, Mishra N (2023) Paraptosis: a unique cell death mode for targeting cancer. Front Pharmacol 14:1159409PubMedPubMedCentral
Hariprabu KNG, Sathya M, Vimalraj S (2021) CRISPR/Cas9 in cancer therapy: a review with a special focus on tumor angiogenesis. Int J Biol Macromol 192:913PubMed
He G, Li Y, Younis MR, Fu L-H, He T, Lei S, Lin J, Huang P (2022) Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy. Nat Commun 13:6238PubMedPubMedCentral
Heydari R, Motieiyan E, Aliabadi A, Abdolmaleki S, Ghadermazi M, Yarmohammadi N (2020a) Synthesis, crystallographic studies, electrochemical and in vitro cytotoxicity properties of two Mn (II) and U (IV) complexes containing dipicolinic acid and 4-dimethylaminopyridine. Polyhedron 181:114477
Heydari R, Motieiyan E, Abdolmaleki S, Aliabadi A, Ghadermazi M, Bagheri F, Amiri Rudbari H (2020b) X-ray crystal structure, thermal behavior and evaluation as an in vitro cytotoxic agent of a tin (IV) complex containing dipicolinic acid. J Coord Chem 73:2347
Hu C, Cai L, Liu S, Liu Y, Zhou Y, Pang M (2020) Copper-doped nanoscale covalent organic polymer for augmented photo/chemodynamic synergistic therapy and immunotherapy. Bioconjug Chem 31:1661PubMed
Huang C, Tang J, Liu Y, Chen T, Qi J, Sun S, Hao H, Zeng W, Zhao J, Wu M (2023) Hyperthermia-triggered NO release based on Cu-doped polypyrrole for synergistic catalytic/gas cancer therapy. Acta Biomater 167:463PubMed
Hussain A, AlAjmi MF, Rehman MT, Amir S, Husain FM, Alsalme A, Siddiqui MA, AlKhedhairy AA, Khan RA (2019) Copper (II) complexes as potential anticancer and nonsteroidal anti-inflammatory agents: in vitro and in vivo studies. Sci Rep 9:5237PubMedPubMedCentral
Ilbasmis-Tamer S, Turk M, Evran Ş, Boyaci IH, Ciftci H, Tamer U (2023) Cytotoxic, apoptotic and necrotic effects of starch coated copper nanoparticles on Capan 1 pancreatic cancer cells. J Drug Deliv Sci Technol 79:104077
Jenkins H, MacLean L, McClean S, Cooke G, Devereux M, Howe O, Pereira MD, May NV, Enyedy ÉA, Creaven BS (2023) Structural and solution speciation studies on selected [Cu (NN)(OO)] complexes and an investigation of their biomimetic activity, ROS generation and their cytotoxicity in normoxic, hypoxic and anoxic environments in MCF-7 breast cancer-derived cells. J Inorg Biochem 249:112383PubMed
Jensen EL, Gonzalez-Ibanez AM, Mendoza P, Ruiz LM, Riedel CA, Simon F et al (2019) Copper deficiency-induced anemia is caused by a mitochondrial metabolic reprograming in erythropoietic cells. Metallomics 11:282PubMed
Ji P, Wang P, Chen H, Xu Y, Ge J, Tian Z, Yan Z (2023) Potential of copper and copper compounds for anticancer applications. Pharmaceuticals 16:234PubMedPubMedCentral
Kang X, Wang J, Huang CH, Wibowo FS, Amin R, Chen P, Li F (2023) Diethyldithiocarbamate copper nanoparticle overcomes resistance in cancer therapy without inhibiting P-glycoprotein. Nanomed Nanotech Biol Med 47:102620
Karginova O, Weekley CM, Raoul A, Alsayed A, Wu T, Lee SS-Y et al (2019) Inhibition of copper transport induces apoptosis in triple-negative breast cancer cells and suppresses tumor angiogenesis. Mol Cancer Ther 18:873PubMed
Karpenko MN, Muruzheva ZM, Ilyechova EY, Babich PS, Puchkova LV (2023) Abnormalities in copper status associated with an elevated risk of Parkinson’s phenotype development. Antioxidants 12:1654PubMedPubMedCentral
Kaska WC, Carrans C, Michalowski J, Jackson J, Levinson W (1978) Inhibition of the RNA dependent DNA polymerase and the malignant transforming ability of Rous sarcoma virus by thiosemicarbazone- transition metal complexes. Bioinorg Chem 8:245
Kathiresan S, Mugesh S, Annaraj J, Murugan M (2017) Mixed-ligand copper (II) Schiff base complexes: the vital role of co-ligands in DNA/protein interactions and cytotoxicity. New J Chem 41:1267
Khaksar S, Panjehpour A, Ghadermazi E, Motieiyan E, Aliabadi A, Rostamnia S, Marabello D, Abdolmaleki S (2023a) Study on crystallographic structure and antiproliferative effect of mixed-ligand strontium (II) complex and N, Nˊ–bis (2-hydroxy-5-methylphenyl) pyridine-2, 6-dicarboxamide ligand. J Mol Struct 1274:134432
Khaksar S, Aliabadi A, Panjehpour A, Abdolmaleki S (2023b) Effect of the extra-nuclear cation on the cytotoxicity and mechanism of action of pyridine-2, 6-dicarboxylate Ga (III) complexes. Toxicology 495:153609PubMed
Khan RA et al (2016) Transition-metal norharmane compounds as possible cytotoxic agents: new insights based on a coordination chemistry perspective. J Inorg Biochem 165:128PubMed
Koo S, Park OK, Kim J, Han SI, Yoo TY, Lee N, Kim YG, Kim H, Lim C, Bae JS, Yoo J (2022) Enhanced chemodynamic therapy by Cu–Fe peroxide nanoparticles: tumor microenvironment-mediated synergistic Fenton reaction. ACS Nano 16:2535PubMed
Kostova I, Momekov G, Zaharieva M, Karaivanova M (2005) Cytotoxic activity of new lanthanum(III) complexes of bis-coumarins. Eur J Med Chem 40:542PubMed
Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513PubMed
Li GY, Du KJ, Wang JQ, Liang JW, Kou JF, Hou XJ, Ji LN, Chao H (2013) Synthesis, crystal structure, DNA interaction and anticancer activity of tridentate copper (II) complexes. J Inorg Biochem 119:43PubMed
Li N, Sun Q, Yu Z, Gao X, Pan W, Wan X, Tang B (2018) Nuclear-targeted photothermal therapy prevents cancer recurrence with near-infrared triggered copper sulfide nanoparticles. ACS Nano 12:5197PubMed
Lin LS, Huang T, Song J, Ou XY, Wang Z, Deng H, Tian R, Liu Y, Wang JF, Liu Y, Yu G (2019) Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy. J Am Chem Soc 141:9937PubMed
Liu T, Karlsen M, Karlberg AM, Redalen KR (2020) Hypoxia imaging and theranostic potential of [(64)Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms. Eur J Nucl Med Mol Imaging Res 10:33
Liu B, Bian Y, Liang S, Yuan M, Dong S, He F, Gai S, Yang P, Cheng Z, Lin J (2021a) One-step integration of tumor microenvironment-responsive calcium and copper peroxides nanocomposite for enhanced chemodynamic/ion-interference therapy. ACS Nano 16:617PubMed
Liu M, Wu H, Wang S, Hu J, Sun B (2021b) Glutathione-triggered nanoplatform for chemodynamic/metal-ion therapy. J Mater Chem B 9:9413PubMed
Liu S-Y, Xu Y, Yang H, Liu L, Zhao M, Yin W, Xu Y-T, Huang Y, Tan C, Dai Z et al (2021c) Ultrathin 2D Copper(I) 1,2,4-triazolate coordination polymer nanosheets for efficient and selective gene silencing and photodynamic therapy. Adv Mater 33:e2100849PubMed
Liu J, Peng Y, Wei W (2022a) Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends Cell Biol 32:30PubMed
Liu T, Redalen KR, Karlsen M (2022b) Development of an automated production process of [(64)Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications. J Labelled Comp Radiopharm 65:191PubMedPubMedCentral
Liu Z, Ma H, Lai Z (2023a) The role of ferroptosis and cuproptosis in curcumin against hepatocellular carcinoma. Molecules 28:1623PubMedPubMedCentral
Liu L, Zhang H, Peng L, Wang D, Zhang Y, Yan B, Xie J, Xing S, Peng F, Liu X (2023b) A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy. Acta Biomater 158:660PubMed
Lopez J, Ramchandani D, Vahdat L (2019) Copper depletion as a therapeutic strategy in cancer. Met Ions Life Sci 19:303
Ma Z, Shao J, Bao W, Qiang Z, Xu J (2014) A thiosemicarbazone copper(II) complex as a potential anticancer agent. J Coord Chem 68:277
Machado JF, Marques F, Pinheiro T, de Brito MJ, Scalese G, Pérez-Díaz L, Otero L, António JP, Gambino D, Morais TS (2023) Copper (I)-thiosemicarbazone complexes with dual anticancer and antiparasitic activity. ChemMedChem 18:e202300074PubMed
Magrì A, Tabbì G, Naletova I, Attanasio F, Arena G, Rizzarelli E (2022) A deeper insight in metal binding to the hCtr1 N-terminus fragment: affinity, speciation and binding mode of binuclear Cu2+ and mononuclear ag+ complex species. Int J Mol Sci 23:2929PubMedPubMedCentral
Mariani D, Ghasemishahrestani Z, Freitas W, Pezzuto P, Costa-da-Silva AC, Tanuri A, Kanashiro MM, Fernandes C, Horn A Jr, Pereira MD (2021) Antitumoral synergism between a copper (II) complex and cisplatin improves in vitro and in vivo anticancer activity against melanoma, lung and breast cancer cells. Biochim Biophys Acta-Gen Subj 1865:129963PubMed
Marzano C, Gandin V, Pellei M, Colavito D, Papini G, Lobbia GG, Del Giudice E, Porchia M, Tisato F, Santini C (2008) In vitro antitumor activity of the water soluble copper(I) complexes bearing the Tris(hydroxymethyl)phosphine ligand. J Med Chem 51:798PubMed
Marzano C, Pellei M, Tisato F, Santini C (2009) Copper complexes as anticancer agents. Anticancer Agents Med Chem 9:185PubMed
Mascia M, Villano C, De Francesco V, Schips L, Marchioni M, Cindolo L (2021) Efficacy and safety of the 64Cu(II)Cl2 PET/CT for urological malignancies: phase IIa clinical study. Clin Nuclear Med 46:443
Matsumoto H, Yoshii Y, Baden A, Kaneko E, Hashimoto H, Suzuki H et al (2019) Preclinical pharmacokinetic and safety studies of copper-diacetyl-bis(N(4)-methylthiosemicarbazone) (Cu-ATSM): translational studies for internal radiotherapy. Transl Oncol 12:1206PubMedPubMedCentral
Maurer RI, Blower PJ, Dilworth JR, Reynolds CA, Zheng Y, Mullen GE (2002) Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals. J Med Chem 45:1420PubMed
McMillan DD, Maeda J, Bell JJ, Genet MD, Phoonswadi G, Mann KA et al (2015) Validation of 64Cu-ATSM damaging DNA via high-LET Auger electron emission. J Radiat Res 56:784PubMedPubMedCentral
Mhaske A, Dileep KV, Kumar M, Poojary M, Pandhare K, Zhang KY, Scaria V, Binukumar BK (2020) ATP7A Clinical Genetics Resource—a comprehensive clinically annotated database and resource for genetic variants in ATP7A gene. Comput Struct Biotechnol J 18:2347PubMedPubMedCentral
Molinaro C, Martoriati A, Pelinski L, Cailliau K (2020) Copper complexes as anticancer agents targeting topoisomerases I and II. Cancers 12:2863PubMedPubMedCentral
Nakamura H, Takada K (2021) Reactive oxygen species in cancer: current findings and future directions. Cancer Sci 112:3945PubMedPubMedCentral
Nam B, Lee W, Sarkar S, Kim JH, Bhise A, Park H et al (2022) In vivo detection of hydrogen sulfide in the brain of live mouse: application in neuroinflammation models. Eur J Nucl Med Mol Imaging 49:4073PubMed
Narayanan G, Bharathidevi SR, Vuyyuru H, Muthuvel B, Konerirajapuram Natrajan SC (2013) CTR1 silencing inhibits angiogenesis by limiting copper entry into endothelial cells. PLoS ONE 8:e71982PubMedPubMedCentral
Obata A, Yoshimoto M, Kasamatsu S, Naiki H, Takamatsu S, Kashikura K et al (2003) Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG. Nucl Med Biol 30:529PubMed
Oe S, Miyagawa K, Honma Y, Harada M (2016) Copper induces hepatocyte injury due to endoplasmic reticulum stress in cultured cells and patients with Wilson disease. Exp Cell Res 347:192PubMed
Orlov IA, Sankova TP, Skvortsov AN, Klotchenko SA, Sakhenberg EI, Mekhova AA, Kiseleva IV, Ilyechova EY, Puchkova LV (2023) Properties of recombinant extracellular N-terminal domain of human high-affinity copper transporter 1 (hNdCTR1) and its interactions with Cu (ii) and Ag (i) ions. Dalton Trans 52:3403PubMed
Ozalp-Yaman S, de Hoog P, Amadei G, Pitie M, Gamez P, Dewelle J, Mijatovic T, Meunier B, Kiss R, Reedijk J (2008) Platinated copper(3-Clip-Phen) complexes as effective DNA-cleaving and cytotoxic agents. Chem Eur J 14:3418PubMed
Padhye S, Afrasiabi Z, Sinn E, Fok J, Mehta K, Rath N (2005) Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone. Inorg Chem 44:1154PubMed
Panichelli P, Villano C, Cistaro A, Bruno A, Barbato F, Piccardo A (2016) Imaging of brain tumors with copper-64 chloride: early experience and results. Cancer Biother Radiopharm 31:159PubMed
Paparo F, Peirano A, Matos J, Bacigalupo L, Rossi U, Mussetto I (2020) Diagnostic value of retrospectively fused (64)CuCl(2) PET/MRI in biochemical relapse of prostate cancer: comparison with fused (18)F-Choline PET/MRI, (64)CuCl2 PET/CT, (18)F-Choline PET/CT, and mpMRI. Abdom Radiol 45:3896
Patel RN, Kumar S, Pandeya KB (2002) E.s.r., visible and SOD studies of imidazolate bridged Cu2II, II, CuIIZnII and CuIINiII complexes with pentamethyldiethylenetriamine as capping ligand: a plausible model for superoxide dismutase. J Inorg Biochem 89:61PubMed
Piccardo A, Paparo F, Puntoni M, Righi S, Bottoni G, Bacigalupo L (2018) 64CuCl2 PET/CT in prostate cancer relapse. J Nucl Med 59:444PubMed
Piroš M, Schoeller M, Koňariková K, Valentová J, Švorc Ľ, Moncoľ J, Valko M, Švorec J (2023) Structural and biological properties of heteroligand copper complexes with diethylnicotinamide and various fenamates: preparation, structure, spectral properties and hirshfeld surface analysis. Inorganics 11:108
Pitie M, Donnadieu B, Meunier B (1998a) Preparation of the new bis(phenanthroline) ligand “Clip-Phen” and evaluation of the nuclease activity of the corresponding copper complex. Inorg Chem 37:3486PubMed
Pitie M, Sudres B, Meunier B (1998b) Dramatic increase of the DNA cleavage activity of Cu(Clip-phen) by fixing the bridging linker on the C3 position of the phenanthroline units. Chem Commun 23:2597
Pitie M, Boldron C, Gornitzka H, Hemmert C, Donnadieu B, Meunier B (2003) DNA cleavage by copper complexes of 2- and 3-clip-phen derivatives. Eur J Inorg Chem 3:528
Rajendiran V, Karthik R, Palaniandavar M, Stoeckli-Evans H, Periasamy VS, Akbarsha MA, Srinag BS, Krishnamurthy H (2007) Mixed-ligand Copper(II)-phenolate complexes: effect of coligand on enhanced DNA and protein binding, DNA cleavage, and anticancer activity. Inorg Chem 46:8208PubMed
Raptopoulou CP, Paschalidou S, Pantazaki AA, Terzis A, Perlepes SP, Lialiaris T, Bakalbassis EG, Mrozinski J, Kyriakidis DA (1998) Bis(acetato)bis(1-methyl-4,5-diphenylimidazole)copper(II): preparation, characterization, crystal structure, DNA strand breakage and cytogenetic effect. J Inorg Biochem 71:15PubMed
Righi S, Ugolini M, Bottoni G, Puntoni M, Iacozzi M, Paparo F (2018) Biokinetic and dosimetric aspects of 64CuCl2 in human prostate cancer: possible theranostic implications. Eur J Nucl Med Mol Imaging Res 8:18
Ritacca AG, Falcone E, Doumi I, Vileno B, Faller P, Sicilia E (2023) Dual role of glutathione as a reducing agent and Cu-ligand governs the ROS production by anticancer Cu-thiosemicarbazone complexes. Inorg Chem 62:3957PubMedPubMedCentral
Rodić MV, Leovac VM, Jovanović LS, Spasojević V, Joksović MD, Stanojković T, Matić IZ, Vojinović-Ješić LS, Marković V (2016) Synthesis, characterization, cytotoxicity and antiangiogenic activity of copper (II) complexes with 1-adamantoyl hydrazone bearing pyridine rings. Eur J Med Chem 115:75–81PubMed
Rodriguez-Arguelles MC, Sanchez A, Ferrari MB, Fava GG, Pelizzi C, Pelosi G, Albertini R, Lunghi P, Pinelli S (1999) Transition-metal complexes of isatin-β-thiosemicarbazone X-ray crystal structure of two nickel complexes. J Inorg Biochem 73:7PubMed
Saczewski F, Dziemidowicz-Borys E, Bednarski PJ, Gruenert R, Gdaniec M, Tabin P (2006) Synthesis, crystal structure and biological activities of copper(II) complexes with chelating bidentate 2-substituted benzimidazole ligands. J Inorg Biochem 100:1389PubMed
Saha DK, Padhye S, Padhye S (2001) Targeting estrogen receptor sites in human breast cancer cell line T47D with copper conjugates of nonsteroidal antiinflammatory drug derivatives: antiproliferative activity of ketoprofen derivative and its copper complex. Met-Based Drugs 8:73PubMedPubMedCentral
Saha DK, Sandbhor U, Shirisha K, Padhye S, Deobagkar D, Anson CE, Powell AK (2004) A novel mixed-ligand antimycobacterial dimeric copper complex of ciprofloxacin and phenanthroline. Bioorg Med Chem Lett 14:3027PubMed
Savi A, Incerti E, Fallanca F, Bettinardi V, Rossetti F, Monterisi C et al (2017) First evaluation of PET-based human biodistribution and dosimetry of (18)F-FAZA, a tracer for imaging tumor hypoxia. J Nucl Med 58:1224PubMed
Shanbhag V, Jasmer-McDonald K, Zhu S, Martin AL, Gudekar N, Khan A et al (2019) ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. Proc Natl Acad Sci USA 116:6836PubMedPubMedCentral
Shao J, Ma Z-Y, Li A, Liu Y-H, Xie C-Z, Qiang Z-Y, Xu J-Y (2014) Thiosemicarbazone Cu(II) and Zn(II) complexes as potential anticancer agents: syntheses, crystal structure, DNA cleavage, cytotoxicity and apoptosis induction activity. J Inorg Biochem 136:13PubMed
Shen W-Y, Jia C-P, Liao L-Y, Chen L-L, Hou C, Liu Y-H, Liang H, Chen Z-F (2022) Copper(II) complexes of halogenated quinoline Schiff base derivatives enabled cancer therapy through glutathione-assisted chemodynamic therapy and inhibition of autophagy flux. J Med Chem 65:5134PubMed
Shi Z, Yao C, Shui Y, Li S, Yan H (2023) Research progress on the mechanism of angiogenesis in wound repair and regeneration. Front Phys 14:1284981
Shimada K, Reznik E, Stokes ME, Krishnamoorthy L, Bos PH, Song Y, Quartararo CE, Pagano NC, Carpizo DR, deCarvalho AC et al (2018) Copper-binding small molecule induces oxidative stress and cell-cycle arrest in glioblastoma-patient-derived cells. Cell Chem Biol 25:585PubMedPubMedCentral
Shobha Devi C, Thulasiram B, Aerva RR, Nagababu P (2018) Recent advances in copper intercalators as anticancer agents. J Fluoresc 28:1195PubMed
Shubin AV, Demidyuk IV, Komissarov AA, Rafieva LM, Kostrov SV (2016) Cytoplasmic vacuolization in cell death and survival. Oncotarget 7:55863–55889PubMedPubMedCentral
Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, Murphy MP, Yamamoto M, Winterbourn C (2022) Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat Rev Mol Cell Biol 23:499PubMed
Sigman DS, Graham DR, D’Aurora V, Stern AM (1979) Oxygen-dependent cleavage of DNA by the 1,10-phenanthroline-cuprous complex Inhibition of E coli DNA polymerase I. J Biol Chem 254:12269PubMed
Sigman DS, Landgraf R, Perrin DM, Pearson L (1996) Nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives. Met Ions Biol Syst 33:485PubMed
Song Y, Zhan J, Li M, Zhao H, Shi G, Wu M, Fang H (2022) Enhancement of the water affinity of histidine by zinc and copper ions. Int J Mol Sci 23:3957PubMedPubMedCentral
Sperandio S, de Belle I, Bredesen DE (2000) An alternative, nonapoptotic form of programmed cell death. Proc Natl Acad Sci USA 97:14376PubMedPubMedCentral
Su Y, Zhang X, Li S, Xie W, Guo J (2022) Emerging roles of the copper-CTR1 axis in tumorigenesis. Mol Cancer Res 20:1339PubMed
Szilagyi I, Labadi I, Hernadi K, Palinko I, Nagy NV, Korecz L, Rockenbauer A, Kele Z, Kiss T (2005) Speciation study of an imidazolate-bridged copper(II)-zinc(II) complex in aqueous solution. J Inorg Biochem 99:1619PubMed
Takasawa M, Moustafa RR, Baron JC (2008) Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke. Stroke 39:1629PubMed
Tamura H, Imai H, Kuwahara J, Sugiura Y (1987) A new antitumor complex: bis(acetato)bis(imidazole)copper(II). J Am Chem Soc 109:6870
Tang X, Yan Z, Miao Y, Ha W, Li Z, Yang L, Mi D (2023) Copper in cancer: from limiting nutrient to therapeutic target. Front Oncol 13:1209156PubMedPubMedCentral
Tardito S, Marchiò L (2009) Copper compounds in anticancer strategies. Curr Med Chem 16:1325PubMed
Tardito S, Bussolati O, Gaccioli F, Gatti R, Guizzardi S, Uggeri J, Marchio L, Lanfranchi M, Franchi-Gazzola R (2006) Nonapoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. Histochem Cell Biol 126:473PubMed
Tateishi K, Tateishi U, Sato M, Yamanaka S, Kanno H, Murata H et al (2013) Application of 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) PET imaging to predict highly malignant tumor grades and hypoxia-inducible factor-1alpha expression in patients with glioma. AJNR Am J Neuroradiol 34:92PubMedPubMedCentral
Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC (2020) Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma. Nat Cell Biol 22:412PubMedPubMedCentral
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD et al (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375:1254PubMedPubMedCentral
Unsoeld M, Lamprecht U, Traub F, Hermes B, Scharpf M, Potkrajcic V, Zips D, Paulsen F (2020) MR thermometry data correlate with pathological response for soft tissue sarcoma of the lower extremity in a single center analysis of prospectively registered patients. Cancers 12:959PubMedPubMedCentral
Ünver H, Dıkmen G, Kiyan HT (2022) Synthesis, X-ray characterization and evaluation of potent anti-angiogenic activity of a novel copper (II)-imidazole-bipyridyl complex. Inorg Nano-Metal Chem 52:1153–1160
Vakili-Samiani S, Khanghah OJ, Gholipour E, Najafi F, Zeinalzadeh E, Samadi P, Sarvarian P, Pourvahdani S, Kelaye SK, Hamblin MR et al (2022) Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy. Mutat Res 824:111776PubMed
Wang J, Xu M, Wang D, Li Z, Primo FL, Tedesco AC, Bi H (2019a) Copper-doped carbon dots for optical bioimaging and photodynamic therapy. Inorg Chem 58:13394PubMed
Wang R, He Z, Cai P, Zhao Y, Gao L, Yang W, Zhao Y, Gao X, Gao F (2019b) Surface-functionalized modified copper sulfide nanoparticles enhance checkpoint blockade tumor immunotherapy by photothermal therapy and antigen capturing. ACS Appl Mater Interfaces 11:13964PubMed
Wang Y, Chen Y, Zhang J, Yang Y, Fleishman JS, Wang Y, Wang J, Chen J, Li Y, Wang H (2023a) Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance. Drug Resist Updat 72:101018PubMed
Wang C, Yang X, Dong C, Chai K, Ruan J, Shi S (2023b) Cu-related agents for cancer therapies. Coord Chem Rev 487:215156
Wang X, Zhu M, Li S, Xu G, Zhang Z, Yang F (2024) Novel mono-, bi-, tri-, and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis. J Inorg Biochem 250:112403PubMed
Wee NKY, Weinstein DC, Fraser ST, Assinder SJ (2013) The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. Int J Biochem Cell Biol 45:960PubMed
Wei J, Fang D (2021) Endoplasmic reticulum stress signaling and the pathogenesis of hepatocarcinoma. Int J Mol Sci 22:1799PubMedPubMedCentral
White C, Kambe T, Fulcher YG, Sachdev SW, Bush AI, Fritsche K et al (2009) Copper transport into the secretory pathway is regulated by oxygen in macrophages. J Cell Sci 122:1315PubMedPubMedCentral
Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH et al (2020) Metabolic dysregulation in the Atp7b-/- wilson’s disease mouse model. Proc Natl Acad Sci USA 117:2076PubMedPubMedCentral
Wózniak-Budych MJ, Staszak K, Staszak M (2023) Copper and copper-based nanoparticles in medicine-perspectives and challenges. Molecules 28:6687PubMedPubMedCentral
Wu Z, Zhang W, Kang YJ (2019) Copper affects the binding of HIF-1α to the critical motifs of its target genes. Metallomics 11:429PubMed
Xie F, Peng F (2017) Radiopharmaceuticals for assessment of altered metabolism and biometal fluxes in brain aging and Alzheimer’s disease with positron emission tomography. J Alzheimers Dis 59:527–536PubMedPubMedCentral
Xie F, Wei W (2022) [64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation. Eur J Nucl Med Mol Imaging 49:3964PubMed
Xu Y, Zhou Q, Feng X, Dai Y, Jiang Y, Jiang W, Liu X, Xing X, Wang Y, Ni Y et al (2020) Disulfiram/copper markedly induced myeloma cell apoptosis through activation of JNK and intrinsic and extrinsic apoptosis pathways. Biomed Pharmacother 126:110048PubMed
Xu Y, Liu S-Y, Zeng L, Ma H, Zhang Y, Yang H, Liu Y, Fang S, Zhao J, Xu Y et al (2022) An enzyme-engineered nonporous copper(I) coordination polymer nanoplatform for cuproptosis-based synergistic cancer therapy. Adv Mater 34:e2204733PubMed
Xu X, Ding C, Zhong H, Qin W, Shu D, Yu M et al (2023) Integrative analysis revealed that distinct cuprotosis patterns reshaped tumor microenvironment and responses to immunotherapy of colorectal cancer. Front Immunol 14:1165101PubMedPubMedCentral
Yan T, Yang K, Chen C, Zhou Z, Shen P, Jia Y, Xue Y, Zhang Z, Shen X, Han X (2021) Synergistic photothermal cancer immunotherapy by Cas9 ribonucleoprotein-based copper sulfide nanotherapeutic platform targeting PTPN2. Biomaterials 279:121233PubMed
Yang L, Yang P, Lip G, Ren J (2023a) Copper homeostasis and cuproptosis in cardiovascular disease therapeutics. Trends Pharmacol Sci 44:573–585PubMed
Yang W, Wang Y, Huang Y, Yu J, Wang T, Li C, Yang L, Zhang P, Shi L, Yin Y, Tao K, Li R (2023b) 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer. Biomed Pharmacother 159:114301PubMed
Yang Y, Huang J, Liu M, Qiu Y, Chen Q, Zhao T, Xiao Z, Yang Y, Jiang Y, Huang Q, Ai K (2023c) Emerging sonodynamic therapy-based nanomedicines for cancer immunotherapy. Adv Sci 10:e2204365
Yang Z, Zhao Z, Cheng H, Shen Y, Xie A, Zhu M (2023d) In-situ fabrication of novel Au nanoclusters-Cu(2+)@sodium alginate/hyaluronic acid nanohybrid gels for cuproptosis enhanced photothermal/photodynamic/chemodynamic therapy via tumor microenvironment regulation. J Colloid Interface Sci 641:215–228PubMed
Yokoi K, Yamaguchi K, Umezawa M, Tsuchiya K, Aoki S (2022) Induction of paraptosis by cyclometalated iridium complex-peptide hybrids and CGP37157 via a mitochondrial Ca2+ overload triggered by membrane fusion between mitochondria and the endoplasmic reticulum. Biochem 61(8):639–655
Yoshii Y, Matsumoto H, Yoshimoto M, Furukawa T, Morokoshi Y, Sogawa C et al (2014) Controlled administration of penicillamine reduces radiation exposure in critical organs during 64Cu-ATSM internal radiotherapy: a novel strategy for liver protection. PLoS ONE 9:e86996PubMedPubMedCentral
Yoshii Y, Matsumoto H, Yoshimoto M, Zhang MR, Oe Y, Kurihara H et al (2018) Multiple administrations of (64)Cu-ATSM as a novel therapeutic option for glioblastoma: a translational study using mice with xenografts. Transl Oncol 11:24PubMed
Yu Z, Hu Y, Sun Y, Sun T (2021) Chemodynamic therapy combined with multifunctional nanomaterials and their applications in tumor treatment. Chemistry 27:13953PubMed
Zhang S, Zhu Y, Tu C, Wei H, Yang Z, Lin L, Ding J, Zhang J, Guo Z (2004) A novel cytotoxic ternary copper(II) complex of 1,10-phenanthroline and L-threonine with DNA nuclease activity. J Inorg Biochem 98:2099PubMed
Zhang Q, Guo X, Cheng Y, Chudal L, Pandey NK, Zhang J et al (2020) Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy, oxidative therapy and immunotherapy for melanoma treatment. Signal Transduct Target Ther 5:58PubMedPubMedCentral
Zhao P, Wang Y, Kang X, Wu A, Yin W, Tang Y, Wang J, Zhang M, Duan Y, Huang Y (2018) Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy. Chem Sci 9:2674PubMedPubMedCentral
Zhao D, Wu Y, Huang W, Gong S, Chen Z (2022) DNA binding, DNA cleavage, cellular uptake, cytotoxicity, and apoptosis-inducing ability of a binuclear Schiff base copper (II) complex. New J Chem 46:15219
Zhao L, Zhong B, Zhu Y, Zheng H, Wang X, Hou Y et al (2023) Nitrovin (Difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). Biochem Pharmacol 210:115487PubMed
Zheng H, Hu C, Quan Y, Ye X, Shi X, Guo Z, Wang X (2023) A copper complex that combats triple negative breast cancer by restraining angiogenesis. Dalton Trans 52:7626–7634PubMed
Zhong X, Wei H-L, Liu W-S, Wang D-Q, Wang X (2007) The crystal structures of copper(II), manganese(II), and nickel(II) complexes of a (Z)-2-hydroxy-N’-(2-oxoindolin-3-ylidene)benzohydrazide-potential antitumor agents. Bioorg Med Chem Lett 17:3774PubMed
Zhou H, Zheng C, Zou G, Tao D, Gong J (2002) G1-phase specific apoptosis in liver carcinoma cell line induced by copper-1,10-phenanthroline. Int J Biochem Cell Biol 34:678PubMed
Zhuang X, Kang Y, Zhao L, Guo S (2022) Design and synthesis of copper nanoparticles for the treatment of human esophageal cancer: introducing a novel chemotherapeutic supplement. J Exp Nanosci 17:274
Zhuo X, Liu Z, Aishajiang R, Wang T, Yu D (2023) Recent progress of copper-based nanomaterials in tumor-targeted photothermal therapy/photodynamic therapy. Pharmaceutics 15:2293PubMedPubMedCentral
Zohrevandi M, Abdolmaleki S, Ghadermazi M, Gholiee Y, Aliabadi A, Motieiyan E, Hakimi M, Marabello D (2022) Synthesis, characterization, crystallographic structure, theoretical studies, and in vitro cytotoxicity assessment of two Gd (III) and Ce (IV) complexes containing pyridine-2, 6-dicarboxylate. Polyhedron 211:115561
Metadata
Title
Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
Authors
Sara Abdolmaleki
Alireza Aliabadi
Samad Khaksar
Publication date
01-04-2024
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 4/2024
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-024-05641-5

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