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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2015

Open Access 01-12-2015 | Case report

Unusual presentation of primary hyperparathyroidism: report of three cases

Authors: Ruibin Huang, Ruyao Zhuang, Yuan Liu, Tianti Li, Jiexiong Huang

Published in: BMC Medical Imaging | Issue 1/2015

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Abstract

Background

Primary hyperparathyroidism is an endocrinopathic condition characterized by hypersecretion of parathyroid hormone. Excess parathyroid hormone results in an altered state of osseous metabolism involving bone resorption and tissue change known as osteitis fibrosa cystica, which is the end stage of primary hyperparathyroidism. Osteitis fibrosa cystica is associated with the development of brown tumors, which are rare because hyperparathyroidism is now usually diagnosed and treated before symptoms develop. Brown tumors are rarely the first symptom of hyperparathyroidism and can occasionally be mistaken for malignancy.

Case Presentation

We herein report three cases of primary hyperparathyroidism with an unusual presentation of brown tumors. All three patients were Asian. In the first case, a 42-year-old man was admitted with a mass mimicking a malignant bone neoplasm in the right mandible as the first manifestation of primary hyperparathyroidism. The second case involved a 25-year-old man admitted with a fracture of his right femur. The third case involved a 43-year-old man with multiple brown tumors in both lower limbs. All three patients underwent successful parathyroidectomy for parathyroid adenomas; one case was complicated by a papillary thyroid carcinoma.

Conclusion

Complete evaluation of the medical history and biochemical and radiographic findings is necessary to achieve a correct diagnosis and avoid unnecessary bone resections in patients with primary hyperparathyroidism.
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Metadata
Title
Unusual presentation of primary hyperparathyroidism: report of three cases
Authors
Ruibin Huang
Ruyao Zhuang
Yuan Liu
Tianti Li
Jiexiong Huang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2015
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-015-0064-1

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