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Head and Neck Pathology
Published in: Head and Neck Pathology 4/2018

01-12-2018 | Case Report

Unusual Multinucleated Giant Cell Reaction in a Tongue Squamous Cell Carcinoma: Histopathological and Immunohistochemical Features

Authors: Celeste Sánchez-Romero, Roman Carlos, Ciro Dantas Soares, Oslei Paes de Almeida

Published in: Head and Neck Pathology | Issue 4/2018

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Abstract

Multinucleated giant cell (MGC) reaction in oral squamous cell carcinoma (OSCC) usually represents a stromal foreign body reaction to keratin from neoplastic epithelial cells. We describe and illustrate by double immunohistochemistry a case of a tongue squamous cell carcinoma (SCC) in a 70-year-old female patient, with a copious MGC reaction not associated to keratin, showing a histopathological pattern not described before. The MGCs were directly associated with neoplastic cells, which are phagocytosed by the MGCs. Immunohistochemistry for CD68, AE1/AE3, CD163, CD11c, RANK, RANK-L, OPG were performed, as well as double staining for CD68 and AE1/AE3 to better illustrate the relationship between MGCs and neoplastic cells. The clinical and biological significance of this pattern of MGC reaction in OSCC needs to be better elucidated.
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Metadata
Title
Unusual Multinucleated Giant Cell Reaction in a Tongue Squamous Cell Carcinoma: Histopathological and Immunohistochemical Features
Authors
Celeste Sánchez-Romero
Roman Carlos
Ciro Dantas Soares
Oslei Paes de Almeida
Publication date
01-12-2018
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 4/2018
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-018-0892-8

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