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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 4/2017

01-12-2017 | Images

Unusual Hypergranular Myelomatous Plasma Cells

Authors: Giovanni D’Arena, Pellegrino Musto

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 4/2017

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Excerpt

An 85-year-old man was diagnosed with Multiple Myeloma, clinical stage IIIB. He presented with renal failure, anemia, thrombocytopenia, multiple lytic areas of skull, and a narrow band in γ-globulin region. A monoclonal IgG/Kappa immunoglobulin in both serum and urine was found. Bone marrow examination showed 20% atypical plasma cells, almost all of them containing numerous large azurophilic, bright red, cytoplasmic inclusions on May-Grünwald-Giemsa staining with strong positivity to alpha-naphtyl acetate esterase and acid phosphatase (Fig. 1). …
Literature
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Vladareanu AM, Cisleanu D, Dervesteanu M, Onisai M, Bumbea H, Radesi S, Begu M, Cristina B (2008) Myeloma cells with asurophilic granules—an unusual morphological variant—case presentation. J Med Life 1:74–86PubMedPubMedCentral
2.
Hutter G, Nowak D, Balu IW, Thiel E (2009) Auer rod-like intracytoplasmic inclusions in multiple myeloma. A case report and review of the literature. Int J Lab Hematol 31:236–240CrossRefPubMed
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Bain BJ, Siow W, Rahemtulla A, Abdalla S (2014) Azurophilic granules in multiple myeloma cells. Am J Hematol 89:437CrossRefPubMed
Metadata
Title
Unusual Hypergranular Myelomatous Plasma Cells
Authors
Giovanni D’Arena
Pellegrino Musto
Publication date
01-12-2017
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 4/2017
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-017-0786-z

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