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Critical Care
Published in: Critical Care 6/2009

01-12-2009 | Commentary

Unraveling the role of high mobility group box protein 1 in severe trauma

Author: Edward Abraham

Published in: Critical Care | Issue 6/2009

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Abstract

High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflammatory activity, but is able to potentiate inflammatory responses through binding to mediators, such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether inhibition of interactions of HMGB1 and associated molecules with the cell surface can affect outcome after trauma.
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Peltz ED, Moore EE, Eckels PC, Damle SS, Tsuruta Y, Johnson JL, Sauaia A, Silliman CC, Banerjee A, Abraham E: HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock 2009, 32: 17-22. 10.1097/SHK.0b013e3181997173PubMedCentralCrossRefPubMed
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Metadata
Title
Unraveling the role of high mobility group box protein 1 in severe trauma
Author
Edward Abraham
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2009
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc8141

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