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01-01-2017 | Short Communication

Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex

Authors: Márton Rózsa, Judith Baka, Sándor Bordé, Balázs Rózsa, Gergely Katona, Gábor Tamás

Published in: Brain Structure and Function | Issue 1/2017

Abstract

Communication between individual GABAergic cells and their target neurons is mediated by synapses and, in the case of neurogliaform cells (NGFCs), by unitary volume transmission. Effects of non-synaptic volume transmission might involve non-neuronal targets, and astrocytes not receiving GABAergic synapses but expressing GABA receptors are suitable for evaluating this hypothesis. Testing several cortical interneuron types in slices of the rat cerebral cortex, we show selective unitary transmission from NGFCs to astrocytes with an early, GABA_A receptor and GABA transporter-mediated component and a late component that results from the activation of GABA transporters and neuronal GABA_B receptors. We could not detect Ca²⁺ influx in astrocytes associated with unitary GABAergic responses. Our experiments identify a presynaptic cell-type-specific, GABA-mediated communication pathway from individual neurons to astrocytes, assigning a role for unitary volume transmission in the control of ionic and neurotransmitter homeostasis.

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Title: Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex
Authors: Márton Rózsa
Judith Baka
Sándor Bordé
Balázs Rózsa
Gergely Katona
Gábor Tamás
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-015-1166-9

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Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex

Abstract

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Abstract

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