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Published in: Current Oncology Reports 2/2015

01-02-2015 | Breast Cancer (B Overmoyer, Section Editor)

Unique Aspects of Caring for Young Breast Cancer Patients

Authors: Raina M. Ferzoco, Kathryn J. Ruddy

Published in: Current Oncology Reports | Issue 2/2015

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Abstract

Breast cancer is the most commonly diagnosed malignancy in young women in the USA. Although breast cancer mortality has decreased overall, survival rates in young women remain lower than those in older women. Young women with breast cancer comprise a special population due to the aggressive biology of their tumors as well as their unique psychosocial concerns. Although general treatment principles are similar regardless of age, recent developments from research focused on younger women have provided new insights to guide treatment of this special population. This article will focus on these new developments in areas including endocrine therapy and fertility preservation as well as the unique treatment-related sequelae and psychosocial concerns among young women with breast cancer face.
Literature
1.
go back to reference Siegel R et al. Cancer statistics. CA: Cancer J Clin. 2014;64(1):9–29. Siegel R et al. Cancer statistics. CA: Cancer J Clin. 2014;64(1):9–29.
2.
go back to reference DeSantis C et al. Breast cancer statistics. CA: Cancer J Clin. 2014;64(1):52–62. DeSantis C et al. Breast cancer statistics. CA: Cancer J Clin. 2014;64(1):52–62.
5.
go back to reference Gnerlich JL et al. Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg. 2009;208(3):341–7.CrossRefPubMedCentralPubMed Gnerlich JL et al. Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg. 2009;208(3):341–7.CrossRefPubMedCentralPubMed
6.
go back to reference Bleyer A et al. The distinctive biology of cancer in adolescents and young adults. Nat Rev Cancer. 2008;8(4):288–98.CrossRefPubMed Bleyer A et al. The distinctive biology of cancer in adolescents and young adults. Nat Rev Cancer. 2008;8(4):288–98.CrossRefPubMed
8.
go back to reference Collins LC et al. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat. 2012;131(3):1061–6.CrossRefPubMed Collins LC et al. Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat. 2012;131(3):1061–6.CrossRefPubMed
10.
go back to reference Partridge AH et al. Effect of age on breast cancer outcomes in women with human epidermal growth factor receptor 2-positive breast cancer: results from a herceptin adjuvant trial. J Clin Oncol. 2013;31(21):2692–8.CrossRefPubMed Partridge AH et al. Effect of age on breast cancer outcomes in women with human epidermal growth factor receptor 2-positive breast cancer: results from a herceptin adjuvant trial. J Clin Oncol. 2013;31(21):2692–8.CrossRefPubMed
12.
go back to reference Ruddy KJ et al. Breast cancer presentation and diagnostic delays in young women. Cancer. 2014;120(1):20–5.CrossRefPubMed Ruddy KJ et al. Breast cancer presentation and diagnostic delays in young women. Cancer. 2014;120(1):20–5.CrossRefPubMed
13.
go back to reference Fisher B et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–41.CrossRefPubMed Fisher B et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–41.CrossRefPubMed
14.
go back to reference van Dongen JA et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst. 2000;92(14):1143–50.CrossRefPubMed van Dongen JA et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst. 2000;92(14):1143–50.CrossRefPubMed
15.
go back to reference Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet, 2000. 355(9217): p. 1757-70. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet, 2000. 355(9217): p. 1757-70.
16.
go back to reference Botteri E et al. Analysis of local and regional recurrences in breast cancer after conservative surgery. Ann Oncol. 2010;21(4):723–8.CrossRefPubMed Botteri E et al. Analysis of local and regional recurrences in breast cancer after conservative surgery. Ann Oncol. 2010;21(4):723–8.CrossRefPubMed
17.
go back to reference Kurtz JM et al. Why are local recurrences after breast-conserving therapy more frequent in younger patients? J Clin Oncol. 1990;8(4):591–8.PubMed Kurtz JM et al. Why are local recurrences after breast-conserving therapy more frequent in younger patients? J Clin Oncol. 1990;8(4):591–8.PubMed
18.
go back to reference Voogd AC et al. Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials. J Clin Oncol. 2001;19(6):1688–97.PubMed Voogd AC et al. Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials. J Clin Oncol. 2001;19(6):1688–97.PubMed
19.
go back to reference Mahmood U et al. Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2012;83(5):1387–93.CrossRefPubMed Mahmood U et al. Similar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2012;83(5):1387–93.CrossRefPubMed
20.•
go back to reference Partridge AH et al. First international consensus guidelines for breast cancer in young women (BCY1). Breast. 2014;23(3):209–20. Young women with breast cancer comprise a special population due to their unique needs. Little research has been done specifically targeting this group. These guidelines provide treatment recommendations specific to this vulnerable population as well as identify areas for further research.CrossRefPubMed Partridge AH et al. First international consensus guidelines for breast cancer in young women (BCY1). Breast. 2014;23(3):209–20. Young women with breast cancer comprise a special population due to their unique needs. Little research has been done specifically targeting this group. These guidelines provide treatment recommendations specific to this vulnerable population as well as identify areas for further research.CrossRefPubMed
22.
go back to reference Jones NB et al. Contralateral prophylactic mastectomy for unilateral breast cancer: an increasing trend at a single institution. Ann Surg Oncol. 2009;16(10):2691–6.CrossRefPubMed Jones NB et al. Contralateral prophylactic mastectomy for unilateral breast cancer: an increasing trend at a single institution. Ann Surg Oncol. 2009;16(10):2691–6.CrossRefPubMed
23.
go back to reference Katipamula R et al. Trends in mastectomy rates at the Mayo Clinic Rochester: effect of surgical year and preoperative magnetic resonance imaging. J Clin Oncol. 2009;27(25):4082–8.CrossRefPubMedCentralPubMed Katipamula R et al. Trends in mastectomy rates at the Mayo Clinic Rochester: effect of surgical year and preoperative magnetic resonance imaging. J Clin Oncol. 2009;27(25):4082–8.CrossRefPubMedCentralPubMed
24.
go back to reference Pesce, C.E., et al., Changing surgical trends in young patients with early stage breast cancer, 2003 to 2010: a report from the National Cancer Data Base. Journal of the American College of Surgeons, 2014 Pesce, C.E., et al., Changing surgical trends in young patients with early stage breast cancer, 2003 to 2010: a report from the National Cancer Data Base. Journal of the American College of Surgeons, 2014
25.
go back to reference Rosenberg S, S.K., Ruddy K, et al., Factors associated with contralateral prophylactic mastectomy in young women with breast cancer [abstract]. In 36th Annual San Antonio Breast Cancer Symposium 2013: San Antonio, TX. Rosenberg S, S.K., Ruddy K, et al., Factors associated with contralateral prophylactic mastectomy in young women with breast cancer [abstract]. In 36th Annual San Antonio Breast Cancer Symposium 2013: San Antonio, TX.
26.
go back to reference Hughes KS et al. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol. 2013;31(19):2382–7.CrossRefPubMedCentralPubMed Hughes KS et al. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol. 2013;31(19):2382–7.CrossRefPubMedCentralPubMed
27.
go back to reference Darby S et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(9804):1707–16.CrossRefPubMed Darby S et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(9804):1707–16.CrossRefPubMed
28.
go back to reference Poortmans PM et al. The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 “boost versus no boost” trial. Cancer Radiother. 2008;12(6–7):565–70.CrossRefPubMed Poortmans PM et al. The addition of a boost dose on the primary tumour bed after lumpectomy in breast conserving treatment for breast cancer. A summary of the results of EORTC 22881-10882 “boost versus no boost” trial. Cancer Radiother. 2008;12(6–7):565–70.CrossRefPubMed
29.
go back to reference Antonini N et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881-10882. Radiother Oncol. 2007;82(3):265–71.CrossRefPubMed Antonini N et al. Effect of age and radiation dose on local control after breast conserving treatment: EORTC trial 22881-10882. Radiother Oncol. 2007;82(3):265–71.CrossRefPubMed
30.
go back to reference Pan IW, Smith BD, Shih YC. Factors contributing to underuse of radiation among younger women with breast cancer. J Natl Cancer Inst. 2014;106(1):djt340.CrossRefPubMedCentralPubMed Pan IW, Smith BD, Shih YC. Factors contributing to underuse of radiation among younger women with breast cancer. J Natl Cancer Inst. 2014;106(1):djt340.CrossRefPubMedCentralPubMed
31.
go back to reference Ciammella P et al. Toxicity and cosmetic outcome of hypofractionated whole-breast radiotherapy: predictive clinical and dosimetric factors. Radiat Oncol. 2014;9(1):97.CrossRefPubMedCentralPubMed Ciammella P et al. Toxicity and cosmetic outcome of hypofractionated whole-breast radiotherapy: predictive clinical and dosimetric factors. Radiat Oncol. 2014;9(1):97.CrossRefPubMedCentralPubMed
32.
go back to reference Darby SC et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987–98.CrossRefPubMed Darby SC et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987–98.CrossRefPubMed
33.
go back to reference Sikov W, B.D., Perou C. Impact of the addition of carboplatin (Cb) and/or bevacizumab (B) to neoadjuvant weekly paclitaxel (P) followed by dose-dense AC on pathologic complete response (pCR) rates in triple-negative breast cancer (TNBC): CALGB 40603 (Alliance). in 36th Annual San Antonio Breast Cancer Symposium. 2013. San Antonio, TX. Sikov W, B.D., Perou C. Impact of the addition of carboplatin (Cb) and/or bevacizumab (B) to neoadjuvant weekly paclitaxel (P) followed by dose-dense AC on pathologic complete response (pCR) rates in triple-negative breast cancer (TNBC): CALGB 40603 (Alliance). in 36th Annual San Antonio Breast Cancer Symposium. 2013. San Antonio, TX.
34.
go back to reference Davies C et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet. 2011;378(9793):771–84.CrossRefPubMed Davies C et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet. 2011;378(9793):771–84.CrossRefPubMed
35.••
go back to reference Davies C et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013;381(9869):805–16. The ATLAS trial demonstrated statistically significant improvements in breast cancer recurrence and breast cancer-related death when adjuvant tamoxifen was continued for 10 versus 5 years. This provides young women with another treatment option for adjuvant endocrine therapy which must be weighed against the potential side effects of long-term hormonal therapy.CrossRefPubMedCentralPubMed Davies C et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013;381(9869):805–16. The ATLAS trial demonstrated statistically significant improvements in breast cancer recurrence and breast cancer-related death when adjuvant tamoxifen was continued for 10 versus 5 years. This provides young women with another treatment option for adjuvant endocrine therapy which must be weighed against the potential side effects of long-term hormonal therapy.CrossRefPubMedCentralPubMed
36.
go back to reference Gray RG et al. aTTom: long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. ASCO Meet Abstract. 2013;31(18_suppl):5. Gray RG et al. aTTom: long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. ASCO Meet Abstract. 2013;31(18_suppl):5.
38.
go back to reference Decensi A et al. Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial. Circulation. 2005;111(5):650–6.CrossRefPubMed Decensi A et al. Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial. Circulation. 2005;111(5):650–6.CrossRefPubMed
39.••
go back to reference Pagani, O., et al., Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. The New England Journal of Medicine, 2014. The combined results of the TEXT and SOFT trials showed that an aromatase inhibitor plus ovarian function suppression significantly reduced breast cancer recurrence when compared to tamoxifen plus ovarian function suppression in premenopausal women with hormone receptor-positive breast cancer. These results provide premenopausal women with hormone receptor-positive breast cancer with a new adjuvant treatment option, previously only available to postmenopausal women Pagani, O., et al., Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. The New England Journal of Medicine, 2014. The combined results of the TEXT and SOFT trials showed that an aromatase inhibitor plus ovarian function suppression significantly reduced breast cancer recurrence when compared to tamoxifen plus ovarian function suppression in premenopausal women with hormone receptor-positive breast cancer. These results provide premenopausal women with hormone receptor-positive breast cancer with a new adjuvant treatment option, previously only available to postmenopausal women
40.
go back to reference Bernhard J et al. Patient-reported endocrine symptoms, sexual functioning, and quality of life (QoL) in the IBCSG TEXT and SOFT trials: adjuvant treatment with exemestane (E) plus ovarian function suppression (OFS) versus tamoxifen (T) plus OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC). ASCO Meet Abstract. 2014;32(15_suppl):557. Bernhard J et al. Patient-reported endocrine symptoms, sexual functioning, and quality of life (QoL) in the IBCSG TEXT and SOFT trials: adjuvant treatment with exemestane (E) plus ovarian function suppression (OFS) versus tamoxifen (T) plus OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC). ASCO Meet Abstract. 2014;32(15_suppl):557.
41.
go back to reference Coleman R, G.M., Paterson A, et al, Effects of bisphosphonate treatment on recurrence and cause-specific mortality in women with early breast cancer: a meta-analysis of individual patient data from randomised trials. In 36th Annual San Antonio Breast Cancer Symposium 2013: San Antonio, TX. Coleman R, G.M., Paterson A, et al, Effects of bisphosphonate treatment on recurrence and cause-specific mortality in women with early breast cancer: a meta-analysis of individual patient data from randomised trials. In 36th Annual San Antonio Breast Cancer Symposium 2013: San Antonio, TX.
42.••
go back to reference Gnant M et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 2011;12(7):631–41. This study by Gnant et al. demonstrated a significant disease-free survival benefit with the addition of zoledronic acid to anastrazole or tamoxifen, suggesting that premenopausal women with early-stage breast cancer should receive zoledronic acid in addition to adjuvant endocrine therapy.CrossRefPubMed Gnant M et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 2011;12(7):631–41. This study by Gnant et al. demonstrated a significant disease-free survival benefit with the addition of zoledronic acid to anastrazole or tamoxifen, suggesting that premenopausal women with early-stage breast cancer should receive zoledronic acid in addition to adjuvant endocrine therapy.CrossRefPubMed
43.
go back to reference Howard-Anderson J et al. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(5):386–405.CrossRefPubMed Howard-Anderson J et al. Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(5):386–405.CrossRefPubMed
44.
go back to reference Schag CA et al. Assessing problems of cancer patients: psychometric properties of the cancer inventory of problem situations. Health Psychol. 1990;9(1):83–102.CrossRefPubMed Schag CA et al. Assessing problems of cancer patients: psychometric properties of the cancer inventory of problem situations. Health Psychol. 1990;9(1):83–102.CrossRefPubMed
45.
go back to reference Rosenberg, S.M., et al., Treatment-related amenorrhea and sexual functioning in young breast cancer survivors. Cancer, 2014 Rosenberg, S.M., et al., Treatment-related amenorrhea and sexual functioning in young breast cancer survivors. Cancer, 2014
46.
go back to reference Schover LR. Premature ovarian failure and its consequences: vasomotor symptoms, sexuality, and fertility. J Clin Oncol. 2008;26(5):753–8.CrossRefPubMed Schover LR. Premature ovarian failure and its consequences: vasomotor symptoms, sexuality, and fertility. J Clin Oncol. 2008;26(5):753–8.CrossRefPubMed
47.
go back to reference Mortimer JE et al. Effect of tamoxifen on sexual functioning in patients with breast cancer. J Clin Oncol. 1999;17(5):1488–92.PubMed Mortimer JE et al. Effect of tamoxifen on sexual functioning in patients with breast cancer. J Clin Oncol. 1999;17(5):1488–92.PubMed
48.
go back to reference Ruddy KJ et al. Young women with breast cancer: a focus group study of unmet needs. J Clin Oncol. 2013;2(4):153–60. Ruddy KJ et al. Young women with breast cancer: a focus group study of unmet needs. J Clin Oncol. 2013;2(4):153–60.
49.
go back to reference Baucom DH et al. Psychosocial issues confronting young women with breast cancer. Breast Dis. 2005;23:103–13.PubMed Baucom DH et al. Psychosocial issues confronting young women with breast cancer. Breast Dis. 2005;23:103–13.PubMed
50.
go back to reference Compas BE et al. Adjustment to breast cancer: age-related differences in coping and emotional distress. Breast Cancer Res Treat. 1999;54(3):195–203.CrossRefPubMed Compas BE et al. Adjustment to breast cancer: age-related differences in coping and emotional distress. Breast Cancer Res Treat. 1999;54(3):195–203.CrossRefPubMed
51.
go back to reference Partridge AH et al. Web-based survey of fertility issues in young women with breast cancer. J Clin Oncol. 2004;22(20):4174–83.CrossRefPubMed Partridge AH et al. Web-based survey of fertility issues in young women with breast cancer. J Clin Oncol. 2004;22(20):4174–83.CrossRefPubMed
52.
53.
go back to reference Ganz PA et al. Breast cancer in younger women: reproductive and late health effects of treatment. J Clin Oncol. 2003;21(22):4184–93.CrossRefPubMed Ganz PA et al. Breast cancer in younger women: reproductive and late health effects of treatment. J Clin Oncol. 2003;21(22):4184–93.CrossRefPubMed
54.
go back to reference Vanlemmens L et al. The subjective quality of life of young patients with breast cancer and their partners. ASCO Meet Abstracts. 2014;32(15_suppl):9569. Vanlemmens L et al. The subjective quality of life of young patients with breast cancer and their partners. ASCO Meet Abstracts. 2014;32(15_suppl):9569.
55.
go back to reference Duffy CM, Allen SM, Clark MA. Discussions regarding reproductive health for young women with breast cancer undergoing chemotherapy. J Clin Oncol. 2005;23(4):766–73.CrossRefPubMed Duffy CM, Allen SM, Clark MA. Discussions regarding reproductive health for young women with breast cancer undergoing chemotherapy. J Clin Oncol. 2005;23(4):766–73.CrossRefPubMed
56.
57.•
go back to reference Ruddy KJ et al. Prospective study of fertility concerns and preservation strategies in young women with breast cancer. J Clin Oncol. 2014;32(11):1151–6. The possibility of infertility is a major cause for concern in many young women with breast cancer. This study looked at how fertility concerns affect treatment-related decision making in young women and demonstrated that while some women take these concerns into consideration when choosing treatments, few pursue fertility preservation prior to treatment initiation.CrossRefPubMed Ruddy KJ et al. Prospective study of fertility concerns and preservation strategies in young women with breast cancer. J Clin Oncol. 2014;32(11):1151–6. The possibility of infertility is a major cause for concern in many young women with breast cancer. This study looked at how fertility concerns affect treatment-related decision making in young women and demonstrated that while some women take these concerns into consideration when choosing treatments, few pursue fertility preservation prior to treatment initiation.CrossRefPubMed
58.
go back to reference Moore HCF et al. Phase III trial (Prevention of Early Menopause Study [POEMS]-SWOG S0230) of LHRH analog during chemotherapy (CT) to reduce ovarian failure in early-stage, hormone receptor-negative breast cancer: an international Intergroup trial of SWOG, IBCSG, ECOG, and CALGB (Alliance). ASCO Meet Abstracts. 2014;32(15_suppl):LBA505. Moore HCF et al. Phase III trial (Prevention of Early Menopause Study [POEMS]-SWOG S0230) of LHRH analog during chemotherapy (CT) to reduce ovarian failure in early-stage, hormone receptor-negative breast cancer: an international Intergroup trial of SWOG, IBCSG, ECOG, and CALGB (Alliance). ASCO Meet Abstracts. 2014;32(15_suppl):LBA505.
Metadata
Title
Unique Aspects of Caring for Young Breast Cancer Patients
Authors
Raina M. Ferzoco
Kathryn J. Ruddy
Publication date
01-02-2015
Publisher
Springer US
Published in
Current Oncology Reports / Issue 2/2015
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-014-0425-x

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