Skip to main content
Top
Published in: Acta Neurochirurgica 3/2019

01-03-2019 | Case Report - Vascular Neurosurgery - Ischemia

Unexpected immediate postoperative resolution of long-standing neurological deficits following extracranial-intracranial bypass: a report of three cases

Authors: Eric S. Nussbaum, Donald L. Erickson, Kevin M. Kallmes, Leslie A. Nussbaum

Published in: Acta Neurochirurgica | Issue 3/2019

Login to get access

Abstract

While intracranial ischemic insults often result in neuronal death and permanent neurological deficits, some patients may develop potentially reversible neurological dysfunction from persistent hypoperfusion, as surviving neurons remain in an “idling” state. We report a unique series of three patients with long-standing neurological deficits who underwent EC-IC bypass for repeated TIAs and demonstrated unexpected, rapid resolution of long-standing pre-existing neurological deficits. We suggest that these individuals harbored regions of underperfused, idling neurons that responded rapidly to restored cerebral reperfusion.
Literature
1.
go back to reference Dijkhuizen RM (2013) Imaging neuronal loss and recovery in compromised but viable brain tissue. Brain 136:1689–1691CrossRefPubMed Dijkhuizen RM (2013) Imaging neuronal loss and recovery in compromised but viable brain tissue. Brain 136:1689–1691CrossRefPubMed
2.
go back to reference Falkowska A, Gutowska I, Goschorska M, Nowacki P, Chlubek D, Baranowska-Bosiacka I (2015) Energy metabolism of the brain, including the cooperation between astrocytes and neurons, especially in the context of glycogen metabolism. Int J Mol Sci 16:25959–25981CrossRefPubMedPubMedCentral Falkowska A, Gutowska I, Goschorska M, Nowacki P, Chlubek D, Baranowska-Bosiacka I (2015) Energy metabolism of the brain, including the cooperation between astrocytes and neurons, especially in the context of glycogen metabolism. Int J Mol Sci 16:25959–25981CrossRefPubMedPubMedCentral
3.
go back to reference Gazyakan E, Lee CY, Wu CT, Tsao CK, Craft R, Henry SL et al (2015) Indications and outcomes of prophylactic and therapeutic extracranial-to-intracranial arterial bypass for cerebral revascularization. Plast Reconstr Surg Glob Open 3:e372CrossRefPubMedPubMedCentral Gazyakan E, Lee CY, Wu CT, Tsao CK, Craft R, Henry SL et al (2015) Indications and outcomes of prophylactic and therapeutic extracranial-to-intracranial arterial bypass for cerebral revascularization. Plast Reconstr Surg Glob Open 3:e372CrossRefPubMedPubMedCentral
4.
go back to reference Gibbs JM, Wise RJ, Thomas DJ, Mansfield AO, Russell RW (1987) Cerebral haemodynamic changes after extracranial-intracranial bypass surgery. J Neurol Neurosurg Psychiatry 50:140–150CrossRefPubMedPubMedCentral Gibbs JM, Wise RJ, Thomas DJ, Mansfield AO, Russell RW (1987) Cerebral haemodynamic changes after extracranial-intracranial bypass surgery. J Neurol Neurosurg Psychiatry 50:140–150CrossRefPubMedPubMedCentral
5.
go back to reference Greenhalgh RM, Illingworth RD, McFie J, Mills SP, Perkin GD, Rose FC (1980) Extracranial to intracranial microrevascularization for the treatment of completed ischemic stroke. Am Heart J 100:937–938CrossRefPubMed Greenhalgh RM, Illingworth RD, McFie J, Mills SP, Perkin GD, Rose FC (1980) Extracranial to intracranial microrevascularization for the treatment of completed ischemic stroke. Am Heart J 100:937–938CrossRefPubMed
6.
go back to reference Hart RP, Rosner MJ, Muizelaar P (1985) Recovery from aphasia following extracranial-intracranial bypass surgery: case report. J Clin Exp Neuropsychol 7:224–230CrossRefPubMed Hart RP, Rosner MJ, Muizelaar P (1985) Recovery from aphasia following extracranial-intracranial bypass surgery: case report. J Clin Exp Neuropsychol 7:224–230CrossRefPubMed
7.
go back to reference Inoue T, Fujimoto S (2005) Prediction of cerebral blood flow restoration after extracranial-intracranial bypass surgery using superficial temporal artery duplex ultrasonography (STDU). In: Yonekawa Y, Keller E, Sakurai Y, Tsukahara T (eds) New trends of surgery for stroke and its perioperative management. Springer, Vienna, pp 159–163CrossRef Inoue T, Fujimoto S (2005) Prediction of cerebral blood flow restoration after extracranial-intracranial bypass surgery using superficial temporal artery duplex ultrasonography (STDU). In: Yonekawa Y, Keller E, Sakurai Y, Tsukahara T (eds) New trends of surgery for stroke and its perioperative management. Springer, Vienna, pp 159–163CrossRef
8.
go back to reference Jing Z, Shi C, Zhu L, Xiang Y, Chen P, Xiong Z et al (2015) Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab 35:1249–1259CrossRefPubMedPubMedCentral Jing Z, Shi C, Zhu L, Xiang Y, Chen P, Xiong Z et al (2015) Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab 35:1249–1259CrossRefPubMedPubMedCentral
9.
go back to reference Jussen D, Zdunczyk A, Schmidt S, Rosler J, Buchert R, Julkunen P et al (2016) Motor plasticity after extra–intracranial bypass surgery in occlusive cerebrovascular disease. Neurology 87:27–35CrossRefPubMed Jussen D, Zdunczyk A, Schmidt S, Rosler J, Buchert R, Julkunen P et al (2016) Motor plasticity after extra–intracranial bypass surgery in occlusive cerebrovascular disease. Neurology 87:27–35CrossRefPubMed
11.
go back to reference Nussbaum ES, Erickson DL (2000) Extracranial-intracranial bypass for ischemic cerebrovascular disease refractory to maximal medical therapy. Neurosurgery 46:37–42 discussion 42-33CrossRefPubMed Nussbaum ES, Erickson DL (2000) Extracranial-intracranial bypass for ischemic cerebrovascular disease refractory to maximal medical therapy. Neurosurgery 46:37–42 discussion 42-33CrossRefPubMed
12.
go back to reference Nussbaum ES, Janjua TM, Defillo A, Lowary JL, Nussbaum LA (2010) Emergency extracranial-intracranial bypass surgery for acute ischemic stroke. J Neurosurg 112:666–673CrossRefPubMed Nussbaum ES, Janjua TM, Defillo A, Lowary JL, Nussbaum LA (2010) Emergency extracranial-intracranial bypass surgery for acute ischemic stroke. J Neurosurg 112:666–673CrossRefPubMed
13.
go back to reference Payk TR, Wassmann H, Schumacher W, Bollbach R (1986) Psychometric studies of cerebral performance before and following extra-intracranial bypass operations. Nervenarzt 57:244–248PubMed Payk TR, Wassmann H, Schumacher W, Bollbach R (1986) Psychometric studies of cerebral performance before and following extra-intracranial bypass operations. Nervenarzt 57:244–248PubMed
14.
go back to reference Roski R, Spetzler RF, Owen M, Chandar K, Sholl JG, Nulsen FE (1978) Reversal of seven-year old visual field defect with extracranial-intracranial arterial anastomosis. Surg Neurol 10:267–268PubMed Roski R, Spetzler RF, Owen M, Chandar K, Sholl JG, Nulsen FE (1978) Reversal of seven-year old visual field defect with extracranial-intracranial arterial anastomosis. Surg Neurol 10:267–268PubMed
15.
go back to reference Rosner MJ, Corales RL, Becker DP (1982) Cerebral revascularization in the management of stroke. Va Med 109:824–835PubMed Rosner MJ, Corales RL, Becker DP (1982) Cerebral revascularization in the management of stroke. Va Med 109:824–835PubMed
17.
go back to reference The International Cooperative Study of Extracranial/Intracranial Arterial Anastomosis (EC/IC Bypass Study) (1985) Methodology and entry characteristics. The EC/IC bypass study group. Stroke 16(3):397–406CrossRef The International Cooperative Study of Extracranial/Intracranial Arterial Anastomosis (EC/IC Bypass Study) (1985) Methodology and entry characteristics. The EC/IC bypass study group. Stroke 16(3):397–406CrossRef
18.
Metadata
Title
Unexpected immediate postoperative resolution of long-standing neurological deficits following extracranial-intracranial bypass: a report of three cases
Authors
Eric S. Nussbaum
Donald L. Erickson
Kevin M. Kallmes
Leslie A. Nussbaum
Publication date
01-03-2019
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 3/2019
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-019-03817-4

Other articles of this Issue 3/2019

Acta Neurochirurgica 3/2019 Go to the issue