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01-04-2016 | Editorial

Understanding why clinicians should care about danger-associated molecular patterns

Authors: Karim Asehnoune, Richard S. Hotchkiss, Guillaume Monneret

Published in: Intensive Care Medicine | Issue 4/2016

Excerpt

In their recent article in Intensive Care Medicine, Timmermans et al. [1] report on plasma levels of danger-associated molecular patterns (DAMPs) associated with immunosuppression in trauma patients. Over a 10-day monitoring period (starting at the trauma scene), the authors measured a number of parameters in 166 adult patients, including several plasma DAMPs (i.e. mitochondrial DNA, nuclear DNA and heat shock protein-70), cytokines and HLA-DR (human leukocyte antigen–antigen D related) mRNA, and performed functional testing (whole blood cytokine release upon lipopolysaccharide challenge), which is considered to be a good marker of innate immunity functionality. This study provides insight on several aspects of trauma-induced immunosuppression. …

Timmermans K, Kox M, Vaneker M, van den Berg M, John A, van Laarhoven A, van der Hoeven H, Scheffer GJ, Pickkers P (2016) Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients. Intensive Care Med. doi:10.1007/s00134-015-4205-3

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Title: Understanding why clinicians should care about danger-associated molecular patterns
Authors: Karim Asehnoune
Richard S. Hotchkiss
Guillaume Monneret
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 4/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-015-4198-y

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Understanding why clinicians should care about danger-associated molecular patterns

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