Skip to main content
Top
Published in: Tumor Biology 7/2016

01-07-2016 | Review

Understanding the CREB1-miRNA feedback loop in human malignancies

Authors: Ya-Wen Wang, Xu Chen, Rong Ma, Peng Gao

Published in: Tumor Biology | Issue 7/2016

Login to get access

Abstract

cAMP response element binding protein 1 (CREB1, CREB) is a key transcription factor that mediates transcriptional responses to a variety of growth factors and stress signals. CREB1 has been shown to play a critical role in development and progression of tumors. MicroRNAs (miRNAs) are a class of non-coding RNAs. They post-transcriptionally regulate gene expression through pairing with the 3′-UTR of their target mRNAs and thus regulate initiation and progression of various types of human cancers. Recent studies have demonstrated that a number of miRNAs can be transcriptionally regulated by CREB1. Interestingly, CREB1 expression can also be modulated by miRNAs, thus forming a feedback loop. This review outlines the functional roles of CREB1, miRNA, and their interactions in human malignancies. This will help to define a relationship between CREB1 and miRNA in human cancer and develop novel therapeutic strategies.
Appendix
Available only for authorised users
Literature
2.
go back to reference Ito Y. Signals and transcription factors. Gan To Kagaku Ryoho Cancer Chemother. 1989;16(3 Pt 2):509–15. Ito Y. Signals and transcription factors. Gan To Kagaku Ryoho Cancer Chemother. 1989;16(3 Pt 2):509–15.
5.
go back to reference Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, et al. TORCs: transducers of regulated CREB activity. Mol Cell. 2003;12(2):413–23.PubMedCrossRef Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, et al. TORCs: transducers of regulated CREB activity. Mol Cell. 2003;12(2):413–23.PubMedCrossRef
8.
9.
10.
go back to reference Maureira A, Sanchez R, Valenzuela N, Torrejon M, Hinrichs MV, Olate J, et al. The CREB transcription factor controls transcriptional activity of the human RIC8B gene. J Cell Biochem. 2016. doi:10.1002/jcb.25479.PubMed Maureira A, Sanchez R, Valenzuela N, Torrejon M, Hinrichs MV, Olate J, et al. The CREB transcription factor controls transcriptional activity of the human RIC8B gene. J Cell Biochem. 2016. doi:10.​1002/​jcb.​25479.PubMed
11.
12.
go back to reference Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597–610. doi:10.1038/nrg2843.PubMed Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11(9):597–610. doi:10.​1038/​nrg2843.PubMed
20.
31.
go back to reference Zhang JQ, Yao QH, Kuang YQ, Ma Y, Yang LB, Huang HD, et al. Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human Astrocytoma. Hum Pathol. 2014;45(10):2154–61. doi:10.1016/j.humpath.2014.01.025.PubMedCrossRef Zhang JQ, Yao QH, Kuang YQ, Ma Y, Yang LB, Huang HD, et al. Prognostic value of coexistence of abnormal expression of micro-RNA-200b and cyclic adenosine monophosphate-responsive element-binding protein 1 in human Astrocytoma. Hum Pathol. 2014;45(10):2154–61. doi:10.​1016/​j.​humpath.​2014.​01.​025.PubMedCrossRef
33.
go back to reference Chhabra A, Fernando H, Watkins G, Mansel RE, Jiang WG. Expression of transcription factor CREB1 in human breast cancer and its correlation with prognosis. Oncol Rep. 2007;18(4):953–8.PubMed Chhabra A, Fernando H, Watkins G, Mansel RE, Jiang WG. Expression of transcription factor CREB1 in human breast cancer and its correlation with prognosis. Oncol Rep. 2007;18(4):953–8.PubMed
35.
go back to reference Resende C, Regalo G, Duraes C, Pinto MT, Wen X, Figueiredo C, et al. Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPbeta-associated mechanism. Gastric Cancer. 2016;19(1):74–84. doi:10.1007/s10120-014-0448-x.PubMedCrossRef Resende C, Regalo G, Duraes C, Pinto MT, Wen X, Figueiredo C, et al. Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPbeta-associated mechanism. Gastric Cancer. 2016;19(1):74–84. doi:10.​1007/​s10120-014-0448-x.PubMedCrossRef
36.
go back to reference Wang YW, Chen X, Gao JW, Zhang H, Ma RR, Gao ZH, et al. High expression of cAMP-responsive element-binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer. Oncotarget. 2015;6(12):10646–57.PubMedCentralPubMedCrossRef Wang YW, Chen X, Gao JW, Zhang H, Ma RR, Gao ZH, et al. High expression of cAMP-responsive element-binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer. Oncotarget. 2015;6(12):10646–57.PubMedCentralPubMedCrossRef
38.
go back to reference Yu L, Guo X, Zhang P, Qi R, Li Z, Zhang S. Cyclic adenosine monophosphate-responsive element-binding protein activation predicts an unfavorable prognosis in patients with hepatocellular carcinoma. OncoTargets Ther. 2014;7:873–9. doi:10.2147/ott.s63594. Yu L, Guo X, Zhang P, Qi R, Li Z, Zhang S. Cyclic adenosine monophosphate-responsive element-binding protein activation predicts an unfavorable prognosis in patients with hepatocellular carcinoma. OncoTargets Ther. 2014;7:873–9. doi:10.​2147/​ott.​s63594.
45.
go back to reference Wu D, Zhau HE, Huang WC, Iqbal S, Habib FK, Sartor O, et al. cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. Oncogene. 2007;26(35):5070–7. doi:10.1038/sj.onc.1210316.PubMedCrossRef Wu D, Zhau HE, Huang WC, Iqbal S, Habib FK, Sartor O, et al. cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. Oncogene. 2007;26(35):5070–7. doi:10.​1038/​sj.​onc.​1210316.PubMedCrossRef
46.
go back to reference Kumar AP, Bhaskaran S, Ganapathy M, Crosby K, Davis MD, Kochunov P, et al. Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by nexrutine, a phellodendron amurense bark extract. Clin Cancer Res. 2007;13(9):2784–94. doi:10.1158/1078-0432.ccr-06-2974.PubMedCentralPubMedCrossRef Kumar AP, Bhaskaran S, Ganapathy M, Crosby K, Davis MD, Kochunov P, et al. Akt/cAMP-responsive element binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by nexrutine, a phellodendron amurense bark extract. Clin Cancer Res. 2007;13(9):2784–94. doi:10.​1158/​1078-0432.​ccr-06-2974.PubMedCentralPubMedCrossRef
50.
51.
53.
go back to reference Li QQ, Zhang L, Wan HY, Liu M, Li X, Tang H. CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. Oncotarget. 2015. doi:10.18632/oncotarget.5318. Li QQ, Zhang L, Wan HY, Liu M, Li X, Tang H. CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. Oncotarget. 2015. doi:10.​18632/​oncotarget.​5318.
55.
go back to reference Wendler A, Keller D, Albrecht C, Peluso JJ, Wehling M. Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. Oncol Rep. 2011;25(1):273–9.PubMed Wendler A, Keller D, Albrecht C, Peluso JJ, Wehling M. Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. Oncol Rep. 2011;25(1):273–9.PubMed
56.
go back to reference Zhao Y, Deng C, Lu W, Xiao J, Ma D, Guo M, et al. let-7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor alpha signaling in breast cancer. Mol Med (Cambridge, Mass). 2011;17(11–12):1233–41. doi:10.2119/molmed.2010.00225. Zhao Y, Deng C, Lu W, Xiao J, Ma D, Guo M, et al. let-7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor alpha signaling in breast cancer. Mol Med (Cambridge, Mass). 2011;17(11–12):1233–41. doi:10.​2119/​molmed.​2010.​00225.
59.
go back to reference Zhang P, Ma Y, Wang F, Yang J, Liu Z, Peng J, et al. Comprehensive gene and microRNA expression profiling reveals the crucial role of hsa-let-7i and its target genes in colorectal cancer metastasis. Mol Biol Rep. 2012;39(2):1471–8. doi:10.1007/s11033-011-0884-1.PubMedCrossRef Zhang P, Ma Y, Wang F, Yang J, Liu Z, Peng J, et al. Comprehensive gene and microRNA expression profiling reveals the crucial role of hsa-let-7i and its target genes in colorectal cancer metastasis. Mol Biol Rep. 2012;39(2):1471–8. doi:10.​1007/​s11033-011-0884-1.PubMedCrossRef
61.
62.
go back to reference Wang H, Zhang W, Zuo Y, Ding M, Ke C, Yan R, et al. miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer. Tumour Biol. 2015. doi:10.1007/s13277-015-3713-7. Wang H, Zhang W, Zuo Y, Ding M, Ke C, Yan R, et al. miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer. Tumour Biol. 2015. doi:10.​1007/​s13277-015-3713-7.
64.
67.
go back to reference Pan X, Wang ZX, Wang R. MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther. 2010;10(12):1224–32.PubMedCrossRef Pan X, Wang ZX, Wang R. MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol Ther. 2010;10(12):1224–32.PubMedCrossRef
72.
go back to reference Zheng H, Li W, Wang Y, Xie T, Cai Y, Wang Z, et al. miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer. Carcinogenesis. 2014;35(1):173–83. doi:10.1093/carcin/bgt274.PubMedCrossRef Zheng H, Li W, Wang Y, Xie T, Cai Y, Wang Z, et al. miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer. Carcinogenesis. 2014;35(1):173–83. doi:10.​1093/​carcin/​bgt274.PubMedCrossRef
73.
go back to reference Ma G, Dai W, Sang A, Yang X, Gao C. Upregulation of microRNA-23a/b promotes tumor progression and confers poor prognosis in patients with gastric cancer. Int J Clin Exp Pathol. 2014;7(12):8833–40.PubMedCentralPubMed Ma G, Dai W, Sang A, Yang X, Gao C. Upregulation of microRNA-23a/b promotes tumor progression and confers poor prognosis in patients with gastric cancer. Int J Clin Exp Pathol. 2014;7(12):8833–40.PubMedCentralPubMed
74.
75.
76.
go back to reference Cai S, Chen R, Li X, Cai Y, Ye Z, Li S, et al. Downregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway. Oncotarget. 2015;6(6):3904–17.PubMedCentralPubMedCrossRef Cai S, Chen R, Li X, Cai Y, Ye Z, Li S, et al. Downregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathway. Oncotarget. 2015;6(6):3904–17.PubMedCentralPubMedCrossRef
77.
go back to reference Macartney-Coxson DP, Hood KA, Shi HJ, Ward T, Wiles A, O’Connor R, et al. Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer. 2008;8:187. doi:10.1186/1471-2407-8-187.PubMedCentralPubMedCrossRef Macartney-Coxson DP, Hood KA, Shi HJ, Ward T, Wiles A, O’Connor R, et al. Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer. 2008;8:187. doi:10.​1186/​1471-2407-8-187.PubMedCentralPubMedCrossRef
78.
go back to reference Knosel T, Schluns K, Stein U, Schwabe H, Schlag PM, Dietel M, et al. Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer. Neoplasia (New York, NY). 2004;6(1):23–8.CrossRef Knosel T, Schluns K, Stein U, Schwabe H, Schlag PM, Dietel M, et al. Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer. Neoplasia (New York, NY). 2004;6(1):23–8.CrossRef
80.
go back to reference Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, et al. Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, −224, −132 and let7g. Radiother Oncol. 2013;108(3):451–7. doi:10.1016/j.radonc.2013.06.032.PubMedCrossRef Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, et al. Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, −224, −132 and let7g. Radiother Oncol. 2013;108(3):451–7. doi:10.​1016/​j.​radonc.​2013.​06.​032.PubMedCrossRef
81.
go back to reference Zhang Y, He X, Liu Y, Ye Y, Zhang H, He P, et al. MicroRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. Oncol Rep. 2012;27(3):685–94. doi:10.3892/or.2011.1561.PubMed Zhang Y, He X, Liu Y, Ye Y, Zhang H, He P, et al. MicroRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. Oncol Rep. 2012;27(3):685–94. doi:10.​3892/​or.​2011.​1561.PubMed
91.
go back to reference Li H, Xie S, Liu M, Chen Z, Liu X, Wang L, et al. The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis. Int J Oncol. 2014;45(1):197–208. doi:10.3892/ijo.2014.2415.PubMed Li H, Xie S, Liu M, Chen Z, Liu X, Wang L, et al. The clinical significance of downregulation of mir-124-3p, mir-146a-5p, mir-155-5p and mir-335-5p in gastric cancer tumorigenesis. Int J Oncol. 2014;45(1):197–208. doi:10.​3892/​ijo.​2014.​2415.PubMed
93.
go back to reference Dohi O, Yasui K, Gen Y, Takada H, Endo M, Tsuji K, et al. Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma. Int J Oncol. 2013;42(2):411–8. doi:10.3892/ijo.2012.1724.PubMed Dohi O, Yasui K, Gen Y, Takada H, Endo M, Tsuji K, et al. Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma. Int J Oncol. 2013;42(2):411–8. doi:10.​3892/​ijo.​2012.​1724.PubMed
96.
go back to reference Li Z, Li D, Zhang G, Xiong J, Jie Z, Cheng H, et al. Methylation-associated silencing of MicroRNA-335 contributes tumor cell invasion and migration by interacting with RASA1 in gastric cancer. Am J Cancer Res. 2014;4(6):648–62.PubMedCentralPubMed Li Z, Li D, Zhang G, Xiong J, Jie Z, Cheng H, et al. Methylation-associated silencing of MicroRNA-335 contributes tumor cell invasion and migration by interacting with RASA1 in gastric cancer. Am J Cancer Res. 2014;4(6):648–62.PubMedCentralPubMed
98.
go back to reference Meng Y, Zou Q, Liu T, Cai X, Huang Y, Pan J. MicroRNA-335 inhibits proliferation, cell-cycle progression, colony formation, and invasion via targeting PAX6 in breast cancer cells. Molecular Med Rep. 2015;11(1):379–85. doi:10.3892/mmr.2014.2684. Meng Y, Zou Q, Liu T, Cai X, Huang Y, Pan J. MicroRNA-335 inhibits proliferation, cell-cycle progression, colony formation, and invasion via targeting PAX6 in breast cancer cells. Molecular Med Rep. 2015;11(1):379–85. doi:10.​3892/​mmr.​2014.​2684.
104.
go back to reference Wang K, Chen X, Zhan Y, Jiang W, Liu X, Wang X, et al. miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W. Tumour Biol. 2015. doi:10.1007/s13277-015-3382-6. Wang K, Chen X, Zhan Y, Jiang W, Liu X, Wang X, et al. miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W. Tumour Biol. 2015. doi:10.​1007/​s13277-015-3382-6.
105.
106.
go back to reference Cao J, Cai J, Huang D, Han Q, Yang Q, Li T, et al. miR-335 represents an invasion suppressor gene in ovarian cancer by targeting Bcl-w. Oncol Rep. 2013;30(2):701–6. doi:10.3892/or.2013.2482.PubMed Cao J, Cai J, Huang D, Han Q, Yang Q, Li T, et al. miR-335 represents an invasion suppressor gene in ovarian cancer by targeting Bcl-w. Oncol Rep. 2013;30(2):701–6. doi:10.​3892/​or.​2013.​2482.PubMed
108.
go back to reference Heidary MF, Mahmoodzadeh Hosseini H, Mehdizadeh Aghdam E, Nourani MR, Ranjbar R, Mirnejad R, et al. Overexpression of metastatic related microRNAs, Mir-335 and Mir-10b, by staphylococcal enterotoxin B in the metastatic breast cancer cell line. Adv Pharma Bull. 2015;5(2):255–9. doi:10.15171/apb.2015.035.CrossRef Heidary MF, Mahmoodzadeh Hosseini H, Mehdizadeh Aghdam E, Nourani MR, Ranjbar R, Mirnejad R, et al. Overexpression of metastatic related microRNAs, Mir-335 and Mir-10b, by staphylococcal enterotoxin B in the metastatic breast cancer cell line. Adv Pharma Bull. 2015;5(2):255–9. doi:10.​15171/​apb.​2015.​035.CrossRef
109.
go back to reference Cheng Q, Cao H, Chen Z, Ma Z, Wan X, Peng R, et al. PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells. Mol Med Rep. 2014;10(1):399–404. doi:10.3892/mmr.2014.2150.PubMed Cheng Q, Cao H, Chen Z, Ma Z, Wan X, Peng R, et al. PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells. Mol Med Rep. 2014;10(1):399–404. doi:10.​3892/​mmr.​2014.​2150.PubMed
110.
go back to reference Zhang BJ, Gong HY, Zheng F, Liu DJ, Liu HX. Up-regulation of miR-335 predicts a favorable prognosis in esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7(9):6213–8.PubMedCentralPubMed Zhang BJ, Gong HY, Zheng F, Liu DJ, Liu HX. Up-regulation of miR-335 predicts a favorable prognosis in esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7(9):6213–8.PubMedCentralPubMed
114.
go back to reference Adi Harel S, Bossel Ben-Moshe N, Aylon Y, Bublik DR, Moskovits N, Toperoff G, et al. Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. Cell Death Differ. 2015;22(8):1328–40. doi:10.1038/cdd.2014.221.PubMedCentralPubMedCrossRef Adi Harel S, Bossel Ben-Moshe N, Aylon Y, Bublik DR, Moskovits N, Toperoff G, et al. Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. Cell Death Differ. 2015;22(8):1328–40. doi:10.​1038/​cdd.​2014.​221.PubMedCentralPubMedCrossRef
115.
go back to reference Attar M, Arefian E, Nabiuni M, Adegani FJ, Bakhtiari SH, Karimi Z, et al. MicroRNA 17–92 expressed by a transposone-based vector changes expression level of cell-cycle-related genes. Cell Biol Int. 2012;36(11):1005–12. doi:10.1042/cbi20110089.PubMedCrossRef Attar M, Arefian E, Nabiuni M, Adegani FJ, Bakhtiari SH, Karimi Z, et al. MicroRNA 17–92 expressed by a transposone-based vector changes expression level of cell-cycle-related genes. Cell Biol Int. 2012;36(11):1005–12. doi:10.​1042/​cbi20110089.PubMedCrossRef
118.
go back to reference Chen L, Yang Q, Kong WQ, Liu T, Liu M, Li X, et al. MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas. IUBMB life. 2012;64(7):628–35. doi:10.1002/iub.1030.PubMedCrossRef Chen L, Yang Q, Kong WQ, Liu T, Liu M, Li X, et al. MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas. IUBMB life. 2012;64(7):628–35. doi:10.​1002/​iub.​1030.PubMedCrossRef
120.
go back to reference Noguchi S, Kumazaki M, Yasui Y, Mori T, Yamada N, Akao Y. MicroRNA-203 regulates melanosome transport and tyrosinase expression in melanoma cells by targeting kinesin superfamily protein 5b. J Investig Dermatol. 2014;134(2):461–9. doi:10.1038/jid.2013.310.PubMedCrossRef Noguchi S, Kumazaki M, Yasui Y, Mori T, Yamada N, Akao Y. MicroRNA-203 regulates melanosome transport and tyrosinase expression in melanoma cells by targeting kinesin superfamily protein 5b. J Investig Dermatol. 2014;134(2):461–9. doi:10.​1038/​jid.​2013.​310.PubMedCrossRef
122.
go back to reference Noguchi S, Kumazaki M, Mori T, Baba K, Okuda M, Mizuno T, et al. Analysis of microRNA-203 function in CREB/MITF/RAB27a pathway: comparison between canine and human melanoma cells. Vet Comp Oncol. 2014. doi:10.1111/vco.12118. Noguchi S, Kumazaki M, Mori T, Baba K, Okuda M, Mizuno T, et al. Analysis of microRNA-203 function in CREB/MITF/RAB27a pathway: comparison between canine and human melanoma cells. Vet Comp Oncol. 2014. doi:10.​1111/​vco.​12118.
127.
go back to reference Chiyomaru T, Seki N, Inoguchi S, Ishihara T, Mataki H, Matsushita R, et al. Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer. Int J Oncol. 2015;46(2):487–96. doi:10.3892/ijo.2014.2752.PubMed Chiyomaru T, Seki N, Inoguchi S, Ishihara T, Mataki H, Matsushita R, et al. Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer. Int J Oncol. 2015;46(2):487–96. doi:10.​3892/​ijo.​2014.​2752.PubMed
128.
go back to reference Goto Y, Kojima S, Nishikawa R, Enokida H, Chiyomaru T, Kinoshita T, et al. The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. Oncotarget. 2014;5(17):7748–59.PubMedCentralPubMedCrossRef Goto Y, Kojima S, Nishikawa R, Enokida H, Chiyomaru T, Kinoshita T, et al. The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. Oncotarget. 2014;5(17):7748–59.PubMedCentralPubMedCrossRef
133.
go back to reference Zhang S, Liu F, Mao X, Huang J, Yang J, Yin X, et al. Elevation of miR-27b by HPV16 E7 inhibits PPARgamma expression and promotes proliferation and invasion in cervical carcinoma cells. Int J Oncol. 2015. doi:10.3892/ijo.2015.3162. Zhang S, Liu F, Mao X, Huang J, Yang J, Yin X, et al. Elevation of miR-27b by HPV16 E7 inhibits PPARgamma expression and promotes proliferation and invasion in cervical carcinoma cells. Int J Oncol. 2015. doi:10.​3892/​ijo.​2015.​3162.
136.
138.
go back to reference Chang TH, Huang HY, Hsu JB, Weng SL, Horng JT, Huang HD. An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs. BMC Bioinforma. 2013;14 Suppl 2:S4. doi:10.1186/1471-2105-14-s2-s4. Chang TH, Huang HY, Hsu JB, Weng SL, Horng JT, Huang HD. An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs. BMC Bioinforma. 2013;14 Suppl 2:S4. doi:10.​1186/​1471-2105-14-s2-s4.
139.
go back to reference Messeguer X, Escudero R, Farre D, Nunez O, Martinez J, Alba MM. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics (Oxford, Engl). 2002;18(2):333–4.CrossRef Messeguer X, Escudero R, Farre D, Nunez O, Martinez J, Alba MM. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics (Oxford, Engl). 2002;18(2):333–4.CrossRef
143.
go back to reference Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 2008;68(11):4123–32. doi:10.1158/0008-5472.can-08-0325.PubMedCrossRef Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 2008;68(11):4123–32. doi:10.​1158/​0008-5472.​can-08-0325.PubMedCrossRef
144.
go back to reference Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, et al. Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 2010;31(12):2066–73. doi:10.1093/carcin/bgq203.PubMedCrossRef Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, et al. Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 2010;31(12):2066–73. doi:10.​1093/​carcin/​bgq203.PubMedCrossRef
148.
go back to reference Wang LG, Ni Y, Su BH, Mu XR, Shen HC, Du JJ. MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met. Int J Oncol. 2013;42(3):957–62. doi:10.3892/ijo.2013.1767.PubMed Wang LG, Ni Y, Su BH, Mu XR, Shen HC, Du JJ. MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met. Int J Oncol. 2013;42(3):957–62. doi:10.​3892/​ijo.​2013.​1767.PubMed
149.
go back to reference Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, et al. MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. Curr Mol Med. 2013;13(4):467–78.PubMedCrossRef Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, et al. MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. Curr Mol Med. 2013;13(4):467–78.PubMedCrossRef
153.
go back to reference Liu J, Shi W, Wu C, Ju J, Jiang J. miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (review). BioMed Rep. 2014;2(1):7–11. doi:10.3892/br.2013.199.PubMed Liu J, Shi W, Wu C, Ju J, Jiang J. miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (review). BioMed Rep. 2014;2(1):7–11. doi:10.​3892/​br.​2013.​199.PubMed
158.
go back to reference Nurul-Syakima AM, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A, Learn-Han L. Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. Int J Mol Med. 2011;28(3):327–36. doi:10.3892/ijmm.2011.714.PubMed Nurul-Syakima AM, Yoke-Kqueen C, Sabariah AR, Shiran MS, Singh A, Learn-Han L. Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers. Int J Mol Med. 2011;28(3):327–36. doi:10.​3892/​ijmm.​2011.​714.PubMed
160.
go back to reference Li D, Jian W, Wei C, Song H, Gu Y, Luo Y, et al. Down-regulation of miR-181b promotes apoptosis by targeting CYLD in thyroid papillary cancer. Int J Clin Exp Pathol. 2014;7(11):7672–80.PubMedCentralPubMed Li D, Jian W, Wei C, Song H, Gu Y, Luo Y, et al. Down-regulation of miR-181b promotes apoptosis by targeting CYLD in thyroid papillary cancer. Int J Clin Exp Pathol. 2014;7(11):7672–80.PubMedCentralPubMed
162.
164.
go back to reference Lu F, Zhang J, Ji M, Li P, Du Y, Wang H, et al. miR-181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1. Int J Oncol. 2014;45(1):383–92. doi:10.3892/ijo.2014.2390.PubMed Lu F, Zhang J, Ji M, Li P, Du Y, Wang H, et al. miR-181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1. Int J Oncol. 2014;45(1):383–92. doi:10.​3892/​ijo.​2014.​2390.PubMed
165.
go back to reference Schaefer A, Jung M, Mollenkopf HJ, Wagner I, Stephan C, Jentzmik F, et al. Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int J Cancer. 2010;126(5):1166–76. doi:10.1002/ijc.24827.PubMed Schaefer A, Jung M, Mollenkopf HJ, Wagner I, Stephan C, Jentzmik F, et al. Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int J Cancer. 2010;126(5):1166–76. doi:10.​1002/​ijc.​24827.PubMed
166.
go back to reference Guo JX, Tao QS, Lou PR, Chen XC, Chen J, Yuan GB. miR-181b as a potential molecular target for anticancer therapy of gastric neoplasms. Asian Pac J Cancer Prev. 2012;13(5):2263–7.PubMedCrossRef Guo JX, Tao QS, Lou PR, Chen XC, Chen J, Yuan GB. miR-181b as a potential molecular target for anticancer therapy of gastric neoplasms. Asian Pac J Cancer Prev. 2012;13(5):2263–7.PubMedCrossRef
167.
go back to reference Tang X, Zheng D, Hu P, Zeng Z, Li M, Tucker L, et al. Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the beta-catenin/TCF/LEF-1 pathway in gastric cancer cells. Nucleic Acids Res. 2014;42(5):2988–98. doi:10.1093/nar/gkt1275.PubMedCrossRef Tang X, Zheng D, Hu P, Zeng Z, Li M, Tucker L, et al. Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the beta-catenin/TCF/LEF-1 pathway in gastric cancer cells. Nucleic Acids Res. 2014;42(5):2988–98. doi:10.​1093/​nar/​gkt1275.PubMedCrossRef
169.
go back to reference Zhu YJ, Xu B, Xia W. Hsa-mir-182 downregulates RASA1 and suppresses lung squamous cell carcinoma cell proliferation. Clin Lab. 2014;60(1):155–9.PubMed Zhu YJ, Xu B, Xia W. Hsa-mir-182 downregulates RASA1 and suppresses lung squamous cell carcinoma cell proliferation. Clin Lab. 2014;60(1):155–9.PubMed
175.
go back to reference Zhang Y, Wang X, Wang Z, Tang H, Fan H, Guo Q. miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer. Oncol Rep. 2015;33(5):2592–8. doi:10.3892/or.2015.3833.PubMed Zhang Y, Wang X, Wang Z, Tang H, Fan H, Guo Q. miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer. Oncol Rep. 2015;33(5):2592–8. doi:10.​3892/​or.​2015.​3833.PubMed
178.
go back to reference Tang L, Chen F, Pang EJ, Zhang ZQ, Jin BW, Dong WF. MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Oncol Rep. 2015;33(4):1707–16. doi:10.3892/or.2015.3798.PubMed Tang L, Chen F, Pang EJ, Zhang ZQ, Jin BW, Dong WF. MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Oncol Rep. 2015;33(4):1707–16. doi:10.​3892/​or.​2015.​3798.PubMed
179.
go back to reference Li X, Luo F, Li Q, Xu M, Feng D, Zhang G, et al. Identification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance. Oncol Rep. 2011;26(6):1431–9. doi:10.3892/or.2011.1437.PubMed Li X, Luo F, Li Q, Xu M, Feng D, Zhang G, et al. Identification of new aberrantly expressed miRNAs in intestinal-type gastric cancer and its clinical significance. Oncol Rep. 2011;26(6):1431–9. doi:10.​3892/​or.​2011.​1437.PubMed
182.
go back to reference Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008;10(5):593–601. doi:10.1038/ncb1722.PubMedCrossRef Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008;10(5):593–601. doi:10.​1038/​ncb1722.PubMedCrossRef
183.
go back to reference Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68(19):7846–54. doi:10.1158/0008-5472.can-08-1942.PubMedCrossRef Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68(19):7846–54. doi:10.​1158/​0008-5472.​can-08-1942.PubMedCrossRef
184.
185.
go back to reference Imaoka H, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, et al. Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer. Gastric Cancer. 2015. doi:10.1007/s10120-015-0521-0.PubMed Imaoka H, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, et al. Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer. Gastric Cancer. 2015. doi:10.​1007/​s10120-015-0521-0.PubMed
186.
go back to reference Zhou X, Xu G, Yin C, Jin W, Zhang G. Down-regulation of miR-203 induced by helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK. Oncotarget. 2014;5(22):11631–40.PubMedCentralPubMedCrossRef Zhou X, Xu G, Yin C, Jin W, Zhang G. Down-regulation of miR-203 induced by helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK. Oncotarget. 2014;5(22):11631–40.PubMedCentralPubMedCrossRef
187.
go back to reference Siu MK, Abou-Kheir W, Yin JJ, Chang YS, Barrett B, Suau F, et al. Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. Oncotarget. 2014;5(11):3770–84.PubMedCentralPubMedCrossRef Siu MK, Abou-Kheir W, Yin JJ, Chang YS, Barrett B, Suau F, et al. Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. Oncotarget. 2014;5(11):3770–84.PubMedCentralPubMedCrossRef
188.
go back to reference Liao H, Bai Y, Qiu S, Zheng L, Huang L, Liu T, et al. MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget. 2015;6(11):8914–28.PubMedCentralPubMedCrossRef Liao H, Bai Y, Qiu S, Zheng L, Huang L, Liu T, et al. MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget. 2015;6(11):8914–28.PubMedCentralPubMedCrossRef
193.
195.
go back to reference Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, et al. Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. Cancer Med. 2015;4(5):745–58. doi:10.1002/cam4.409.PubMedCentralPubMedCrossRef Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, et al. Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. Cancer Med. 2015;4(5):745–58. doi:10.​1002/​cam4.​409.PubMedCentralPubMedCrossRef
196.
go back to reference Furlong F, Fitzpatrick P, O’Toole S, Phelan S, McGrogan B, Maguire A, et al. Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer. J Pathol. 2012;226(5):746–55. doi:10.1002/path.3035.PubMedCentralPubMedCrossRef Furlong F, Fitzpatrick P, O’Toole S, Phelan S, McGrogan B, Maguire A, et al. Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer. J Pathol. 2012;226(5):746–55. doi:10.​1002/​path.​3035.PubMedCentralPubMedCrossRef
197.
go back to reference Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, et al. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol. 2010;11(2):136–46. doi:10.1016/s1470-2045(09)70343-2.PubMedCrossRef Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, et al. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol. 2010;11(2):136–46. doi:10.​1016/​s1470-2045(09)70343-2.PubMedCrossRef
198.
go back to reference Lin X, Rice KL, Buzzai M, Hexner E, Costa FF, Kilpivaara O, et al. miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. Leukemia. 2013;27(2):344–52. doi:10.1038/leu.2012.224.PubMedCrossRef Lin X, Rice KL, Buzzai M, Hexner E, Costa FF, Kilpivaara O, et al. miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. Leukemia. 2013;27(2):344–52. doi:10.​1038/​leu.​2012.​224.PubMedCrossRef
203.
go back to reference Yan Z, Shah PK, Amin SB, Samur MK, Huang N, Wang X, et al. Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 2012;40(17):e135. doi:10.1093/nar/gks395.PubMedCentralPubMedCrossRef Yan Z, Shah PK, Amin SB, Samur MK, Huang N, Wang X, et al. Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 2012;40(17):e135. doi:10.​1093/​nar/​gks395.PubMedCentralPubMedCrossRef
Metadata
Title
Understanding the CREB1-miRNA feedback loop in human malignancies
Authors
Ya-Wen Wang
Xu Chen
Rong Ma
Peng Gao
Publication date
01-07-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 7/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5050-x

Other articles of this Issue 7/2016

Tumor Biology 7/2016 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine