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01-09-2014 | Understanding the Disease

Understanding infection susceptibility in patients with acute-on-chronic liver failure

Authors: Nowlan Selvapatt, Arjuna Singanayagam, Julia Wendon, Charalambos Gustav Antoniades

Published in: Intensive Care Medicine | Issue 9/2014

Excerpt

Infection accounts for over 50 % of admissions of cirrhotic patients to hospital and is the main precipitant for the development of multiple organ dysfunction syndrome (MODS), including hepatic encephalopathy, renal, respiratory and circulatory failure, a syndrome referred to as acute-on-chronic liver failure (AoCLF) [1]. Once established, AoCLF carries a prohibitively high 30-day mortality rate in excess of 25 % [2]. In recent census studies from Europe and USA [1, 2], 35 % of patients admitted with AoCLF require organ support, posing a significant burden on critical care services and resources. Despite advances in organ support, little progress has been made in understanding the pathogenesis and treatment of infections in patients with liver disease. …

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Title: Understanding infection susceptibility in patients with acute-on-chronic liver failure
Authors: Nowlan Selvapatt
Arjuna Singanayagam
Julia Wendon
Charalambos Gustav Antoniades
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 9/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3349-x

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Understanding infection susceptibility in patients with acute-on-chronic liver failure

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