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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Ultrasound | Research

The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats

Authors: Jiao Xin, Xinxin Zhan, Fu Zheng, Huazhi Li, Yixiang Wang, Cuiying Li, Jiuhui Jiang

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Given the difficulties or incapacity of teeth movement in orthodontic treatment, the ways to speed tooth movement must be investigated. Besides, nonsteroidal anti-inflammatory drugs (NSAIDs) were utilized to treat pain caused by tooth movement during orthodontic treatment. The purpose of this study is to examine the impact of aspirin and low-frequency high-intensity ultrasound (LFHIU) on rat orthodontic tooth movement in rats.

Methods

Thirty-six male Sprague-Dawley rats were divided into three groups: orthodontic (O), ultrasound-treated orthodontic (OU), and ultrasound-treated orthodontic with aspirin gavage (OUA) group. In the OU and OUA group, LFHIU (44 W/cm2, 28 kHz) was applied to the buccal side of the maxillary first molar alveolar bone for 10 s every day. In the OUA group, aspirin was given by gavage every day. The rats were sacrificed on days 1, 3, 7, and 14.

Results

After ultrasonic treatment, the speed of tooth movement was increased by about 1.5 times. And the number of osteoclasts considerably increased by about 2 times. However, they decreased slightly after aspirin gavage. By Applying ultrasound therapy, Receptor Activator for Nuclear Factor-κ B Ligand (RANKL) levels in periodontal tissue were elevated. Aspirin was able to reduce these increases. Results from Micro Computed Tomography (Micro-CT) revealed that bone mineral density decreased by about 1/5 after ultrasound treatment on the compression side. The rate of bone mineral apposition indicated that bone was forming under tension, and that of the OU group increased by about 1.3 times that O group.

Conclusions

Although aspirin slowed this trend, LFHIU still enhanced overall tooth mobility in orthodontic treatment.
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Metadata
Title
The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats
Authors
Jiao Xin
Xinxin Zhan
Fu Zheng
Huazhi Li
Yixiang Wang
Cuiying Li
Jiuhui Jiang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03359-3

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