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Published in: European Radiology 2/2020

01-02-2020 | Ultrasound | Ultrasound

Learning curve of liver stiffness measurement using a new hybrid machine composed of transient elastography interfaced with ultrasound

Authors: Christophe Cassinotto, Marie-Ange Pierredon-Foulongne, Ali Belgour, Julien Delicque, Laure Escal, Nicolas Molinari, Sophie Anselme, Tony Jacq, Ugo Chamard-Champliaud, Bastien Nicolan, Carole Allimant, Boris Guiu

Published in: European Radiology | Issue 2/2020

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Abstract

Objectives

To assess the learning curve for performing reliable liver stiffness measurements using a new hybrid machine composed of transient elastography (TE) interfaced with an ultrasound device for radiographers and radiologists with different levels of expertise in ultrasound imaging.

Methods

Ten novice operators who had never performed TE measurements were prospectively evaluated from April to October 2018: senior radiologists, young radiologists, fellows, radiographers, and residents, with different levels of experience in abdominal ultrasound imaging. All operators had a short theoretical training followed by a training session under supervision in three patients. Then, each operator had to perform TE in 50 consecutive patients with chronic liver disease, using beforehand ultrasound examination to select measurement area in the right liver lobe, and if needed, the XL probe. Percentages of failures and reliable measurements were compared.

Results

The rates of failures of measurements, poorly reliable, reliable, and very reliable results, were of 4.2% (21/500), 2.4% (12/500), 47.6% (238/500), and 45.8% (229/500), respectively. The rates of reliable plus very reliable results were excellent, ranging from 91 to 96% among all the subgroups. The rates of very reliable, reliable, and unreliable results did not differ between operator subgroups and especially between junior radiologists, senior radiologists, and radiographers. No breaking point was observed in the interquartile range/median values over time.

Conclusion

TE interfaced with ultrasound in this hybrid machine presents no learning curve effect. After a short initial training session, a novice observer is able to perform high rates of reliable and very reliable TE measurements.

Key Points

• When performing liver stiffness measurements using a new hybrid machine composed of transient elastography interfaced with ultrasound, the rate of failures of measurements is very low, below 5%.
• After a short training session and using ultrasound planning, a novice operator, whatever its expertise in ultrasound imaging, is capable of performing high rates of reliable and very reliable measurements.
• No learning curve is needed for performing reliable liver stiffness measurements using this new hybrid machine.
Appendix
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Literature
1.
go back to reference Foucher J, Chanteloup E, Vergniol J et al (2006) Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 55:403–408CrossRef Foucher J, Chanteloup E, Vergniol J et al (2006) Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut 55:403–408CrossRef
2.
go back to reference Friedrich-Rust M, Ong MF, Martens S et al (2008) Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 134:960–974CrossRef Friedrich-Rust M, Ong MF, Martens S et al (2008) Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 134:960–974CrossRef
3.
go back to reference Vergniol J, Foucher J, Terrebonne E et al (2011) Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology 140:1970–9, 9 e1-3CrossRef Vergniol J, Foucher J, Terrebonne E et al (2011) Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology 140:1970–9, 9 e1-3CrossRef
4.
go back to reference de Lédinghen V, Vergniol J, Barthe C et al (2013) Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus. Aliment Pharmacol Ther 37:979–988 de Lédinghen V, Vergniol J, Barthe C et al (2013) Non-invasive tests for fibrosis and liver stiffness predict 5-year survival of patients chronically infected with hepatitis B virus. Aliment Pharmacol Ther 37:979–988
5.
go back to reference Vergniol J, Boursier J, Coutzac C et al (2014) Evolution of noninvasive tests of liver fibrosis is associated with prognosis in patients with chronic hepatitis C. Hepatology 60:65–76CrossRef Vergniol J, Boursier J, Coutzac C et al (2014) Evolution of noninvasive tests of liver fibrosis is associated with prognosis in patients with chronic hepatitis C. Hepatology 60:65–76CrossRef
6.
go back to reference Sandrin L, Catheline S, Tanter M, Hennequin X, Fink M (1999) Time-resolved pulsed elastography with ultrafast ultrasonic imaging. Ultrason Imaging 21:259–272CrossRef Sandrin L, Catheline S, Tanter M, Hennequin X, Fink M (1999) Time-resolved pulsed elastography with ultrafast ultrasonic imaging. Ultrason Imaging 21:259–272CrossRef
7.
go back to reference European Association for the Study of the L (2011) EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 55:245–264CrossRef European Association for the Study of the L (2011) EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 55:245–264CrossRef
8.
go back to reference European Association For The Study Of The L (2012) EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol 57:167–185CrossRef European Association For The Study Of The L (2012) EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol 57:167–185CrossRef
9.
go back to reference Piscaglia F, Salvatore V, Mulazzani L, Cantisani V, Schiavone C (2016) Ultrasound shear wave elastography for liver disease. A critical appraisal of the many actors on the stage. Ultraschall Med 37:1–5CrossRef Piscaglia F, Salvatore V, Mulazzani L, Cantisani V, Schiavone C (2016) Ultrasound shear wave elastography for liver disease. A critical appraisal of the many actors on the stage. Ultraschall Med 37:1–5CrossRef
10.
go back to reference Cassinotto C, Lapuyade B, Mouries A et al (2014) Non-invasive assessment of liver fibrosis with impulse elastography: comparison of Supersonic Shear Imaging with ARFI and FibroScan. J Hepatol 61:550–557CrossRef Cassinotto C, Lapuyade B, Mouries A et al (2014) Non-invasive assessment of liver fibrosis with impulse elastography: comparison of Supersonic Shear Imaging with ARFI and FibroScan. J Hepatol 61:550–557CrossRef
11.
go back to reference Sandrin L, Fourquet B, Hasquenoph JM et al (2003) Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 29:1705–1713CrossRef Sandrin L, Fourquet B, Hasquenoph JM et al (2003) Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 29:1705–1713CrossRef
12.
go back to reference Degos F, Perez P, Roche B et al (2010) Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study). J Hepatol 53:1013–1021CrossRef Degos F, Perez P, Roche B et al (2010) Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study). J Hepatol 53:1013–1021CrossRef
13.
go back to reference Nobili V, Vizzutti F, Arena U et al (2008) Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 48:442–448CrossRef Nobili V, Vizzutti F, Arena U et al (2008) Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 48:442–448CrossRef
14.
go back to reference Zarski JP, Sturm N, Guechot J et al (2012) Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study. J Hepatol 56:55–62CrossRef Zarski JP, Sturm N, Guechot J et al (2012) Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study. J Hepatol 56:55–62CrossRef
15.
go back to reference Boursier J, Zarski JP, de Lédinghen V et al (2013) Determination of reliability criteria for liver stiffness evaluation by transient elastography. Hepatology 57:1182–1191 Boursier J, Zarski JP, de Lédinghen V et al (2013) Determination of reliability criteria for liver stiffness evaluation by transient elastography. Hepatology 57:1182–1191
16.
go back to reference Molinari N, Morena M, Cristol JP, Daurè JP (2002) Free knot splines for biochemical data. Comput Methods Prog Biomed 67:163–167CrossRef Molinari N, Morena M, Cristol JP, Daurè JP (2002) Free knot splines for biochemical data. Comput Methods Prog Biomed 67:163–167CrossRef
17.
go back to reference Kettaneh A, Marcellin P, Douvin C et al (2007) Features associated with success rate and performance of FibroScan measurements for the diagnosis of cirrhosis in HCV patients: a prospective study of 935 patients. J Hepatol 46:628–634CrossRef Kettaneh A, Marcellin P, Douvin C et al (2007) Features associated with success rate and performance of FibroScan measurements for the diagnosis of cirrhosis in HCV patients: a prospective study of 935 patients. J Hepatol 46:628–634CrossRef
18.
go back to reference Boursier J, Konate A, Guilluy M et al (2008) Learning curve and interobserver reproducibility evaluation of liver stiffness measurement by transient elastography. Eur J Gastroenterol Hepatol 20:693–701CrossRef Boursier J, Konate A, Guilluy M et al (2008) Learning curve and interobserver reproducibility evaluation of liver stiffness measurement by transient elastography. Eur J Gastroenterol Hepatol 20:693–701CrossRef
19.
go back to reference Castera L, Foucher J, Bernard PH et al (2010) Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 51:828–835PubMed Castera L, Foucher J, Bernard PH et al (2010) Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 51:828–835PubMed
20.
go back to reference Pang JX, Pradhan F, Zimmer S et al (2014) The feasibility and reliability of transient elastography using Fibroscan(R): a practice audit of 2335 examinations. Can J Gastroenterol Hepatol 28:143–149CrossRef Pang JX, Pradhan F, Zimmer S et al (2014) The feasibility and reliability of transient elastography using Fibroscan(R): a practice audit of 2335 examinations. Can J Gastroenterol Hepatol 28:143–149CrossRef
21.
go back to reference de Lédinghen V, Vergniol J, Foucher J, El-Hajbi F, Merrouche W, Rigalleau V (2010) Feasibility of liver transient elastography with FibroScan using a new probe for obese patients. Liver Int 30:1043–1048 de Lédinghen V, Vergniol J, Foucher J, El-Hajbi F, Merrouche W, Rigalleau V (2010) Feasibility of liver transient elastography with FibroScan using a new probe for obese patients. Liver Int 30:1043–1048
22.
go back to reference Myers RP, Pomier-Layrargues G, Kirsch R et al (2012) Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology 55:199–208CrossRef Myers RP, Pomier-Layrargues G, Kirsch R et al (2012) Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology 55:199–208CrossRef
23.
go back to reference Armstrong MJ, Corbett C, Hodson J et al (2013) Operator training requirements and diagnostic accuracy of Fibroscan in routine clinical practice. Postgrad Med J 89:685–692CrossRef Armstrong MJ, Corbett C, Hodson J et al (2013) Operator training requirements and diagnostic accuracy of Fibroscan in routine clinical practice. Postgrad Med J 89:685–692CrossRef
Metadata
Title
Learning curve of liver stiffness measurement using a new hybrid machine composed of transient elastography interfaced with ultrasound
Authors
Christophe Cassinotto
Marie-Ange Pierredon-Foulongne
Ali Belgour
Julien Delicque
Laure Escal
Nicolas Molinari
Sophie Anselme
Tony Jacq
Ugo Chamard-Champliaud
Bastien Nicolan
Carole Allimant
Boris Guiu
Publication date
01-02-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 2/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06388-1

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