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European Archives of Oto-Rhino-Laryngology

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01-04-2020 | Ultrasound | Head and Neck

Predicting the factors associated with central lymph node metastasis in clinical node-negative (cN0) papillary thyroid microcarcinoma

Authors: Cui Zhang, Bao-jun Li, Zhao Liu, Ling-ling Wang, Wen Cheng

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2020

Abstract

Purpose

The aim of the present study was to investigate the risk factors associated with central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC).

Methods

A total of 553 patients with PTMC confirmed by histological examination, who underwent thyroidectomy and central neck dissection (CND), were enrolled. The clinicopathological and ultrasonographic features from the patients were analyzed retrospectively.

Results

PTMC patient age, Hashimoto thyroiditis (HT), tumor location, extrathyroidal extension (ETE), microcalcification and higher E values were correlated with the incidence of CLNM. Multivariate logistic regression analysis showed that age, HT, tumor location, ETE and E_max were related to the extent of CLNM. Chi-squared automatic interaction detection (CHAID) classification tree model showed that patients with tumor in upper/lower third combined ETE had a high risk of CLNM. Furthermore, cN0 PTMC patients with age ≤ 45 years and ETE had more extensive CLNM.

Conclusion

Our observations could be helpful for the assessment of prognostic factors of PTMC patients with CLNM.

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Title: Predicting the factors associated with central lymph node metastasis in clinical node-negative (cN0) papillary thyroid microcarcinoma
Authors: Cui Zhang
Bao-jun Li
Zhao Liu
Ling-ling Wang
Wen Cheng
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Ultrasound
Hashimoto Thyroiditis
Metastasis
Ultrasound
Thyroidectomy
Thyroidectomy
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-05787-1

At a glance: The STEP trials

Springer Medicine

Predicting the factors associated with central lymph node metastasis in clinical node-negative (cN0) papillary thyroid microcarcinoma

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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