Skip to main content
Top
Published in: Pediatric Nephrology 11/2019

01-11-2019 | Ultrasound | Original Article

Ultrasound dilution and thermodilution versus color Doppler ultrasound for arteriovenous fistula assessment in children on hemodialysis

Authors: Vasiliki Karava, Theresa Kwon, Gilbert Franco, Deschenes Georges, Marie-Alice Macher, Julien Hogan

Published in: Pediatric Nephrology | Issue 11/2019

Login to get access

Abstract

Background

This study is aimed at comparing ultrasound dilution (UD) and thermodilution (TD) with color Doppler ultrasound (CDU) for arteriovenous fistula (AVF) assessment in children on hemodialysis (HD).

Material and methods

All patients were dialysed with the Fresenius 5008 HD machine. UD was performed using the Transonic device. The two methods were compared with CDU performed on a non-HD day. AVF flow rate was expressed as ml/min/1.73 m2.

Results

Sixteen measurements of AVF flow rate and recirculation with UD and TD were compared with CDU in 16 patients with a median weight of 39 kg. Both UD and TD overestimated AVF flow rate when compared with CDU (+437 (95% CI + 200, + 674) and + 476 (95% CI + 80, + 871) ml/min/1.73 m2 for UD and TD, respectively). CDU flow rate was significantly correlated to UD flow rate (r2 = 0.761, p < 0.001), but not to TD flow rate (r2 = 0.164, p = 0.120). Although recirculation in all AVF was estimated to be 0% and < 15% with UD and TD, respectively, 7 significant stenoses were diagnosed by CDU. AVF with stenosis had lower flow rates when measured by CDU, UD or TD, but only CDU measurements reached statistical significance (p = 0.008, p = 0.142 and p = 0.174, respectively).

Conclusion

UD and TD overestimate AVF flow rate when compared with CDU, which is the most reliable non-invasive method for screening vascular access for stenosis. UD seems more accurate than TD for AVF flow rate assessment. Recirculation via UD or TD should not be used for early screening of AVF stenosis in children on HD.
Literature
1.
go back to reference Vascular Access (2006) Work Group (2006) Clinical practice guidelines for vascular access. Am J Kidney Dis 48:S176–S247CrossRef Vascular Access (2006) Work Group (2006) Clinical practice guidelines for vascular access. Am J Kidney Dis 48:S176–S247CrossRef
2.
go back to reference Chand DH, Valentini RP, Kamil ES (2009) Hemodialysis vascular access options in pediatrics: considerations for patients and practitioners. Pediatr Nephrol 24:1121–1128CrossRef Chand DH, Valentini RP, Kamil ES (2009) Hemodialysis vascular access options in pediatrics: considerations for patients and practitioners. Pediatr Nephrol 24:1121–1128CrossRef
3.
go back to reference Karava V, Jehanno P, Kwon T, Deschênes G, Macher MA, Bourquelot P (2018) Autologous arteriovenous fistulas for hemodialysis using microsurgery techniques in children weighing less than 20 kg. Pediatr Nephrol 33:855–862CrossRef Karava V, Jehanno P, Kwon T, Deschênes G, Macher MA, Bourquelot P (2018) Autologous arteriovenous fistulas for hemodialysis using microsurgery techniques in children weighing less than 20 kg. Pediatr Nephrol 33:855–862CrossRef
4.
go back to reference Hogan J, Salomon R, Krid S, Bonnet D, Legendre A (2019) Pulmonary hypertension in an adolescent with end-stage-renal disease—a diagnostic challenge: answers. Pediatr Nephrol 34:73–74CrossRef Hogan J, Salomon R, Krid S, Bonnet D, Legendre A (2019) Pulmonary hypertension in an adolescent with end-stage-renal disease—a diagnostic challenge: answers. Pediatr Nephrol 34:73–74CrossRef
5.
go back to reference Chand D, Poe S, Strife F (2002) Venous pressure monitoring does not accurately predict access failure in children. Pediatr Nephrol 17:765–769CrossRef Chand D, Poe S, Strife F (2002) Venous pressure monitoring does not accurately predict access failure in children. Pediatr Nephrol 17:765–769CrossRef
6.
go back to reference Zamboli P, Fiorini F, D’Amelio A, Fatuzzo P, Granata A (2014) Color Doppler ultrasound and arteriovenous fistulas for hemodialysis. J Ultrasound 17:253–263CrossRef Zamboli P, Fiorini F, D’Amelio A, Fatuzzo P, Granata A (2014) Color Doppler ultrasound and arteriovenous fistulas for hemodialysis. J Ultrasound 17:253–263CrossRef
7.
go back to reference Gadallah MF, Paulson WD, Vickers B, Work J (1998) Accuracy of Doppler ultrasound in diagnosing anatomic stenosis of hemodialysis arteriovenous access as compared with fistulography. Am J Kidney Dis 32:273–277CrossRef Gadallah MF, Paulson WD, Vickers B, Work J (1998) Accuracy of Doppler ultrasound in diagnosing anatomic stenosis of hemodialysis arteriovenous access as compared with fistulography. Am J Kidney Dis 32:273–277CrossRef
8.
go back to reference Mudoni A, Caccetta F, Caroppo M, Musio F, Accogli A, Zacheo MD, Burzo MD, Gallieni M, Nuzzo V (2016) Echo color Doppler ultrasound: a valuable diagnostic tool in the assessment of arteriovenous fistula in hemodialysis patients. J Vasc Access 17:446–452CrossRef Mudoni A, Caccetta F, Caroppo M, Musio F, Accogli A, Zacheo MD, Burzo MD, Gallieni M, Nuzzo V (2016) Echo color Doppler ultrasound: a valuable diagnostic tool in the assessment of arteriovenous fistula in hemodialysis patients. J Vasc Access 17:446–452CrossRef
9.
go back to reference Wiese P, Nonnast-Daniel B (2004) Colour Doppler ultrasound in dialysis access. Nephrol Dial Transplant 19:1956–1963CrossRef Wiese P, Nonnast-Daniel B (2004) Colour Doppler ultrasound in dialysis access. Nephrol Dial Transplant 19:1956–1963CrossRef
10.
go back to reference Ascher E, Hingorani A, Marks N (2010) Duplex scanning-derived access volume flow: novel predictor of success following endovascular repair of failing or nonmaturing arteriovenous fistulae for hemodialysis. Vascular 18:9–13CrossRef Ascher E, Hingorani A, Marks N (2010) Duplex scanning-derived access volume flow: novel predictor of success following endovascular repair of failing or nonmaturing arteriovenous fistulae for hemodialysis. Vascular 18:9–13CrossRef
11.
go back to reference Zeraati A, Beladi Mousavi SS, Beladi Mousavi M (2013) A review article: access recirculation among end stage renal disease patients undergoing maintenance hemodialysis. Nephro Urol Mon 5:728–732CrossRef Zeraati A, Beladi Mousavi SS, Beladi Mousavi M (2013) A review article: access recirculation among end stage renal disease patients undergoing maintenance hemodialysis. Nephro Urol Mon 5:728–732CrossRef
12.
go back to reference Goldstein SL, Allsteadt A, Smith CM, Currier H (2002) Proactive monitoring of pediatric hemodialysis vascular access: effects of ultrasound dilution on thrombosis rates. Kidney Int 62:272–275CrossRef Goldstein SL, Allsteadt A, Smith CM, Currier H (2002) Proactive monitoring of pediatric hemodialysis vascular access: effects of ultrasound dilution on thrombosis rates. Kidney Int 62:272–275CrossRef
13.
go back to reference Goldstein SL, Allsteadt A (2001) Ultrasound dilution evaluation of pediatric hemodialysis vascular access. Kidney Int 59:2357–2360CrossRef Goldstein SL, Allsteadt A (2001) Ultrasound dilution evaluation of pediatric hemodialysis vascular access. Kidney Int 59:2357–2360CrossRef
14.
go back to reference Ashoor IF, Hughson EA, Somers MJG (2015) Arteriovenous access monitoring with ultrasound dilution in a pediatric hemodialysis unit. Blood Purif 39:93–98CrossRef Ashoor IF, Hughson EA, Somers MJG (2015) Arteriovenous access monitoring with ultrasound dilution in a pediatric hemodialysis unit. Blood Purif 39:93–98CrossRef
15.
go back to reference Schneditz D, Wang E, Levin NW (1999) Validation of haemodialysis recirculation and access blood flow measured by thermodilution. Nephrol Dial Transplant 14:376–383CrossRef Schneditz D, Wang E, Levin NW (1999) Validation of haemodialysis recirculation and access blood flow measured by thermodilution. Nephrol Dial Transplant 14:376–383CrossRef
16.
go back to reference Badr B, Bories P, Marais R, Frat B, Seigneuric B, Longlune N, Kamar N, Maggioni S, Rostaing L (2014) Transonic, thermodilution, or ionic dialysance to manage vascular access: which method is best? Hemodial Int 18:127–135CrossRef Badr B, Bories P, Marais R, Frat B, Seigneuric B, Longlune N, Kamar N, Maggioni S, Rostaing L (2014) Transonic, thermodilution, or ionic dialysance to manage vascular access: which method is best? Hemodial Int 18:127–135CrossRef
17.
go back to reference Krivitski NM (1995) Theory and validation of access flow measurement by dilution technique during hemodialysis. Kidney Int 48:244–250CrossRef Krivitski NM (1995) Theory and validation of access flow measurement by dilution technique during hemodialysis. Kidney Int 48:244–250CrossRef
18.
go back to reference Schneditz D, Fan Z, Kaufman A, Levin NW (1998) Measurement of access flow during hemodialysis using the constant infusion approach. ASAIO J 44:74–81CrossRef Schneditz D, Fan Z, Kaufman A, Levin NW (1998) Measurement of access flow during hemodialysis using the constant infusion approach. ASAIO J 44:74–81CrossRef
20.
go back to reference Yeo WS, Ng QX (2018) Disruptive technological advances in vascular access for dialysis: an overview. Pediatr Nephrol 33:2221–2226CrossRef Yeo WS, Ng QX (2018) Disruptive technological advances in vascular access for dialysis: an overview. Pediatr Nephrol 33:2221–2226CrossRef
21.
go back to reference Jackson VE, Hurst H, Mitra S (2018) Structured physical assessment of arteriovenous fistulae in haemodialysis access surveillance: a missed opportunity? J Vasc Access 19:221–229CrossRef Jackson VE, Hurst H, Mitra S (2018) Structured physical assessment of arteriovenous fistulae in haemodialysis access surveillance: a missed opportunity? J Vasc Access 19:221–229CrossRef
22.
go back to reference Tessitore N, Bedogna V, Verlato G, Poli A (2014) The rise and fall of access blood flow surveillance in arteriovenous fistulas. Semin Dial 27:108–118CrossRef Tessitore N, Bedogna V, Verlato G, Poli A (2014) The rise and fall of access blood flow surveillance in arteriovenous fistulas. Semin Dial 27:108–118CrossRef
23.
go back to reference Tessitore N, Lipari G, Poli A, Bedogna V, Baggio E, Loschiavo C, Mansueto G, Lupo A (2004) Can blood flow surveillance and pre-emptive repair of subclinical stenosis prolong the useful life of arteriovenous fistulae? A randomized controlled study. Nephrol Dial Transplant 19:2325–2333CrossRef Tessitore N, Lipari G, Poli A, Bedogna V, Baggio E, Loschiavo C, Mansueto G, Lupo A (2004) Can blood flow surveillance and pre-emptive repair of subclinical stenosis prolong the useful life of arteriovenous fistulae? A randomized controlled study. Nephrol Dial Transplant 19:2325–2333CrossRef
24.
go back to reference Casey ET, Murad MH, Rizvi AZ, Sidawy AN, McGrath MM, Elamin MB, Flynn DN, McCausland FR, Vo DH, El-Zoghby Z, Duncan AA, Tracz MJ, Erwin PJ, Montori VM (2008) Surveillance of arteriovenous hemodialysis access: a systematic review and meta-analysis. J Vasc Surg 48:S48–S54CrossRef Casey ET, Murad MH, Rizvi AZ, Sidawy AN, McGrath MM, Elamin MB, Flynn DN, McCausland FR, Vo DH, El-Zoghby Z, Duncan AA, Tracz MJ, Erwin PJ, Montori VM (2008) Surveillance of arteriovenous hemodialysis access: a systematic review and meta-analysis. J Vasc Surg 48:S48–S54CrossRef
25.
go back to reference Tonelli M, James M, Wiebe N, Jindal K, Hemmelgarn B, Alberta Kidney Disease Network (2008) Ultrasound monitoring to detect access stenosis in hemodialysis patients: a systematic review. Am J Kidney Dis 51:630–640CrossRef Tonelli M, James M, Wiebe N, Jindal K, Hemmelgarn B, Alberta Kidney Disease Network (2008) Ultrasound monitoring to detect access stenosis in hemodialysis patients: a systematic review. Am J Kidney Dis 51:630–640CrossRef
26.
go back to reference Shroff R, Calder F, Bakkaloğlu S, Nagler EV, Stuart S, Stronach L, Schmitt CP, Heckert KH, Bourquelot P, Wagner AM, Paglialonga F, Mitra S, Stefanidis CJ, European Society for Paediatric Nephrology Dialysis Working Group (2019) Vascular access in children requiring maintenance haemodialysis: a consensus document by the European Society for Paediatric Nephrology Dialysis Working Group. Nephrol Dial Transplant. https://doi.org/10.1093/ndt/gfz011 Shroff R, Calder F, Bakkaloğlu S, Nagler EV, Stuart S, Stronach L, Schmitt CP, Heckert KH, Bourquelot P, Wagner AM, Paglialonga F, Mitra S, Stefanidis CJ, European Society for Paediatric Nephrology Dialysis Working Group (2019) Vascular access in children requiring maintenance haemodialysis: a consensus document by the European Society for Paediatric Nephrology Dialysis Working Group. Nephrol Dial Transplant. https://​doi.​org/​10.​1093/​ndt/​gfz011
27.
go back to reference Robbin ML, Oser RF, Allon M, Clements MW, Dockery J, Weber TM, Hamrick-Waller KM, Smith JK, Jones BC, Morgan DE, Saddekni S (1998) Hemodialysis access graft stenosis: US detection. Radiology 208:655–661CrossRef Robbin ML, Oser RF, Allon M, Clements MW, Dockery J, Weber TM, Hamrick-Waller KM, Smith JK, Jones BC, Morgan DE, Saddekni S (1998) Hemodialysis access graft stenosis: US detection. Radiology 208:655–661CrossRef
28.
go back to reference Schwarz C, Mitterbauer C, Boczula M, Maca T, Funovics M, Heinze G, Lorenz M, Kovarik J, Oberbauer R (2003) Flow monitoring: performance characteristics of ultrasound dilution versus color Doppler ultrasound compared with fistulography. Am J Kidney Dis 42:539–545CrossRef Schwarz C, Mitterbauer C, Boczula M, Maca T, Funovics M, Heinze G, Lorenz M, Kovarik J, Oberbauer R (2003) Flow monitoring: performance characteristics of ultrasound dilution versus color Doppler ultrasound compared with fistulography. Am J Kidney Dis 42:539–545CrossRef
29.
go back to reference Aragoncillo I, Abad S, Caldés S (2017) Adding access blood flow surveillance reduces thrombosis and improves arteriovenous fistula patency: a randomized controlled trial. J Vasc Access 18:352–358CrossRef Aragoncillo I, Abad S, Caldés S (2017) Adding access blood flow surveillance reduces thrombosis and improves arteriovenous fistula patency: a randomized controlled trial. J Vasc Access 18:352–358CrossRef
30.
go back to reference Branger B, Granolleras C, Dauzat M, Picard E, Vecina F, Zabadani B, Branchereau P, Fourcade J (2004) Fréquence des thromboses des fistules artério-veineuses pour hémodialyse: apport de deux méthodes de surveillance: le Doppler et la dilution des ultrasons. Nephrologie 25:17–22PubMed Branger B, Granolleras C, Dauzat M, Picard E, Vecina F, Zabadani B, Branchereau P, Fourcade J (2004) Fréquence des thromboses des fistules artério-veineuses pour hémodialyse: apport de deux méthodes de surveillance: le Doppler et la dilution des ultrasons. Nephrologie 25:17–22PubMed
31.
go back to reference Teodorescu V, Gustavson S, Schanzer H (2012) Duplex ultrasound evaluation of hemodialysis access: a detailed protocol. Int J Nephrol 2012:1–7CrossRef Teodorescu V, Gustavson S, Schanzer H (2012) Duplex ultrasound evaluation of hemodialysis access: a detailed protocol. Int J Nephrol 2012:1–7CrossRef
32.
go back to reference Sacquépée M, Tivollier JM, Doussy Y, Quirin N, Valéry JC, Cantin JF (2012) Comparaison des mesures des débits d’abords vasculaires pour hémodialyse obtenues par méthode de thermodilution utilisant le module Blood Temperature Monitoring et par débimétrie doppler. Nephrol Ther 8:96–100CrossRef Sacquépée M, Tivollier JM, Doussy Y, Quirin N, Valéry JC, Cantin JF (2012) Comparaison des mesures des débits d’abords vasculaires pour hémodialyse obtenues par méthode de thermodilution utilisant le module Blood Temperature Monitoring et par débimétrie doppler. Nephrol Ther 8:96–100CrossRef
33.
go back to reference Sands J, Glidden D, Miranda C (1996) Hemodialysis access flow measurement. Comparison of ultrasound dilution and duplex ultrasonography. ASAIO J 42:M899–M901CrossRef Sands J, Glidden D, Miranda C (1996) Hemodialysis access flow measurement. Comparison of ultrasound dilution and duplex ultrasonography. ASAIO J 42:M899–M901CrossRef
34.
go back to reference Depner TA, Krivitski NM (1995) Clinical measurement of blood flow in hemodialysis access fistulae and grafts by ultrasound dilution. ASAIO J 41:M745–M749CrossRef Depner TA, Krivitski NM (1995) Clinical measurement of blood flow in hemodialysis access fistulae and grafts by ultrasound dilution. ASAIO J 41:M745–M749CrossRef
35.
go back to reference Lin CC, Chang CF, Chiou HJ, Sun YC, Chiang SS, Lin MW, Lee PC, Yang WC (2005) Variable pump flow-based Doppler ultrasound method: a novel approach to the measurement of access flow in hemodialysis patients. J Am Soc Nephrol 16:229–236CrossRef Lin CC, Chang CF, Chiou HJ, Sun YC, Chiang SS, Lin MW, Lee PC, Yang WC (2005) Variable pump flow-based Doppler ultrasound method: a novel approach to the measurement of access flow in hemodialysis patients. J Am Soc Nephrol 16:229–236CrossRef
36.
go back to reference Tonelli M, Jindal K, Hirsch D, Taylor S, Kane C, Henbrey S (2001) Screening for subclinical stenosis in native vessel arteriovenous fistulae. J Am Soc Nephrol 12:1729–1733PubMed Tonelli M, Jindal K, Hirsch D, Taylor S, Kane C, Henbrey S (2001) Screening for subclinical stenosis in native vessel arteriovenous fistulae. J Am Soc Nephrol 12:1729–1733PubMed
37.
go back to reference Besarab A, Sherman R (1997) The relationship of recirculation to access blood flow. Am J Kidney Dis 29:223–229CrossRef Besarab A, Sherman R (1997) The relationship of recirculation to access blood flow. Am J Kidney Dis 29:223–229CrossRef
38.
go back to reference Wang E, Schneditz D, Kaufman AM, Levin NW (2000) Sensitivity and specificity of the thermodilution technique in detection of access recirculation. Nephron 85:134–141CrossRef Wang E, Schneditz D, Kaufman AM, Levin NW (2000) Sensitivity and specificity of the thermodilution technique in detection of access recirculation. Nephron 85:134–141CrossRef
Metadata
Title
Ultrasound dilution and thermodilution versus color Doppler ultrasound for arteriovenous fistula assessment in children on hemodialysis
Authors
Vasiliki Karava
Theresa Kwon
Gilbert Franco
Deschenes Georges
Marie-Alice Macher
Julien Hogan
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 11/2019
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-019-04297-5

Other articles of this Issue 11/2019

Pediatric Nephrology 11/2019 Go to the issue