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01-02-2006 | Original Article

Ultra-structural morphological abnormalities of the urinary bladder in streptozotocin-induced diabetic female rats

Authors: Diaa E. E. Rizk, Rengasamy K. Padmanabhan, Saeed Tariq, Mohamed Shafiullah, Ijaz Ahmed

Published in: International Urogynecology Journal | Issue 2/2006

Abstract

The objective of this study was to evaluate the ultra-structural changes in the urinary bladder of diabetic rats in relation to disease duration since the morphological bases of diabetes-induced bladder dysfunction are poorly understood. Urinary bladders were examined chronologically by electron microscopy in a female Wistar-rat model of streptozotocin-induced diabetes mellitus and compared to control samples. Numerous dark mitochondria with swollen cristae and electron lucent, large, calcified and degenerated mitochondria were observed first in the urothelium. Intraepithelial capillaries surrounded by thick collagen were also present. Gap junctions between myocytes were interrupted or extensively widened with reduced mitochondria and caveolae. Collagen accumulation, degenerated nerve fibres and myelin bodies were seen between myocytes with increased collagen content and frequent mast cells, phagocytes and lymphocyte aggregates in the stroma. All ultra-structural lesions became augmented with longer duration of diabetes. Diabetes induces time-dependent pathologic changes in the urinary bladder of rats that might account for bladder dysfunction.

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Title: Ultra-structural morphological abnormalities of the urinary bladder in streptozotocin-induced diabetic female rats
Authors: Diaa E. E. Rizk
Rengasamy K. Padmanabhan
Saeed Tariq
Mohamed Shafiullah
Ijaz Ahmed
Publication date: 01-02-2006
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 2/2006
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-005-1359-5

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Ultra-structural morphological abnormalities of the urinary bladder in streptozotocin-induced diabetic female rats

Abstract

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Abstract

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