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01-07-2017 | CARDIOVASCULAR DISEASE

Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population

Authors: Bernhard M. Kaess, Tonia de las Heras Gala, Astrid Zierer, Christa Meisinger, Simone Wahl, Annette Peters, John Todd, Christian Herder, Cornelia Huth, Barbara Thorand, Wolfgang Koenig

Published in: European Journal of Epidemiology | Issue 7/2017

Abstract

Troponins are sensitive markers of myocardial injury and predictive of cardiovascular events, but conventional assays fail to detect slightly elevated troponins in a considerable proportion of the general population. Using a novel ultrasensitive assay, we explored the relationship of troponin levels with the incidence of coronary heart disease (CHD) in a case-cohort sample (mean age 52.5 ± 0.2 years, 51.5% women) comprising 803 CHD cases and 1942 non-cases. Ultrasensitive troponin I was detectable in 99.9% of available case-cohort samples. In an age- and sex-adjusted model, individuals in the highest quartile of the troponin distribution had a more than threefold increased risk for CHD events compared to those in the bottom quartile [hazard ratio, HR, 3.11; 95% confidence interval (CI) 2.15–4.49]. In a model adjusting for cardiovascular risk factors including C-reactive protein, cystatin C and N-terminal pro brain natriuretic peptide, individuals in the highest troponin I quartile still showed a hazard ratio of 2.58 (95% CI 1.66–4.00) for incident CHD as compared to those in the lowest quartile. Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD.

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Title: Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population
Authors: Bernhard M. Kaess
Tonia de las Heras Gala
Astrid Zierer
Christa Meisinger
Simone Wahl
Annette Peters
John Todd
Christian Herder
Cornelia Huth
Barbara Thorand
Wolfgang Koenig
Publication date: 01-07-2017
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 7/2017
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-017-0266-7

At a glance: The STEP trials

Springer Medicine

Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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