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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

UDP glucuronosyltransferase 2B7 single nucleotide polymorphism (rs7439366) influences heat pain response in human volunteers after i.v. morphine infusion

Authors: KM Meissner, HM Meyer zu Schwabedissen, CG Göpfert, MD Ding, JB Blood, KF Frey, HK Kim, EK Kharasch

Published in: Critical Care | Special Issue 1/2011

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Excerpt

Morphine remains the most widely used intravenous opioid in the perioperative setting worldwide. Maintaining therapeutic CNS concentrations of many opioids is confounded by considerable variability in disposition. Recent findings indicate a role for the UGT2B7 expressed in the liver, for variability of substrate effects. This phenomenon is attributed to genetic and environmental factors. However, evidence for effect variation due to UGT2B7-mediated glucuronization of morphine in humans is lacking. …
Metadata
Title
UDP glucuronosyltransferase 2B7 single nucleotide polymorphism (rs7439366) influences heat pain response in human volunteers after i.v. morphine infusion
Authors
KM Meissner
HM Meyer zu Schwabedissen
CG Göpfert
MD Ding
JB Blood
KF Frey
HK Kim
EK Kharasch
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9783

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