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Obesity Surgery
Published in: Obesity Surgery 2/2017

01-02-2017 | Original Contributions

UCP2 and PLIN1 Expression Affects the Resting Metabolic Rate and Weight Loss on Obese Patients

Authors: Bruno Affonso Parenti de Oliveira, Marcela Augusta de Souza Pinhel, Carolina Ferreira Nicoletti, Cristiana Cortes de Oliveira, Driele Cristina Gomes Quinhoneiro, Natália Yumi Noronha, Priscila Giácomo Fassini, Wilson Araújo da Silva Júnior, Wilson Salgado Junior, Carla Barbosa Nonino

Published in: Obesity Surgery | Issue 2/2017

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Abstract

Background

Analysis of the expression of genes related to the energy metabolism can elucidate the understanding of physiological and genetic factors that contribute to obesity. This study aimed to evaluate the expression of genes and its influence on resting metabolic rate and weight loss in obese patients before and after bariatric surgery.

Methods

This study was conducted on 23 women, who were divided into two groups: bariatric surgery (preoperative and 6 months after surgery) and control. Abdominal subcutaneous adipose tissue samples were collected to analyze the gene expression, and the resting metabolic rate (RMR) was measured by indirect calorimetry.

Results

Significant differences were observed in weight reduction (22 %, p = 0.01), BMI (22.5 %, p = 0.01), and RMR values (10.5 %, p = 0.01) after the bariatric surgery, while the weight-adjusted RMR increased (15.8 %, p = 0.01). Increased UCP2 expression after 6 months of Roux-en-Y gastric bypass (RYGB) as compared to preoperative period (0.764 to 1.268, p = 0.01) was observed. Analysis with weight-adjusted RMR as dependent variable revealed that UCP2 (r 2 = 0.517, p = 0.01) and PLIN1 (r 2 = 0.420, p = 0.04) expression determine the RMR values in preoperative period. Moreover, UCP2 and PLIN1 expression in preoperative period influenced the percentage of weight loss, even when adjusted for age and BMI.

Conclusions

We have demonstrated that after 6 months of bariatric surgery, there is significant increase in the UCP2 expression. Additionally, the expression of UCP2 and PLIN1 genes influences the resting metabolic rate in obese individuals and could predict the weight loss after bariatric surgery.
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Metadata
Title
UCP2 and PLIN1 Expression Affects the Resting Metabolic Rate and Weight Loss on Obese Patients
Authors
Bruno Affonso Parenti de Oliveira
Marcela Augusta de Souza Pinhel
Carolina Ferreira Nicoletti
Cristiana Cortes de Oliveira
Driele Cristina Gomes Quinhoneiro
Natália Yumi Noronha
Priscila Giácomo Fassini
Wilson Araújo da Silva Júnior
Wilson Salgado Junior
Carla Barbosa Nonino
Publication date
01-02-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 2/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2275-0

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