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Osteoporosis International
Published in: Osteoporosis International 4/2019

01-04-2019 | Type 2 Diabetes

Visit-to-visit blood pressure variability and hip fracture risk in older persons

Authors: T.-C. Li, C.-I. Li, C.-S. Liu, W.-Y. Lin, C.-H. Lin, S.-Y. Yang, J.-H. Chiang, C.-C. Lin

Published in: Osteoporosis International | Issue 4/2019

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Abstract

Summary

We investigated the association between blood pressure variability measured by the coefficient of variation (CV) of blood pressure and hip fracture in older persons with diabetes. After excluding patients with acute complications and comorbidities, a positive association with similar magnitude of strength was found between BP variability and hip fracture, compared with that in the original analysis.

Introduction

Hypertension is a risk factor of osteoporosis and hip fracture, but studies have yet to investigate whether blood pressure variability measured by the CV of blood pressure can predict hip fracture in older persons with diabetes.

Methods

We conducted a retrospective cohort study on 21,160 patients who suffered from type 2 diabetes (age ≥ 50 years) and participated in the National Diabetes Care Management Program in Taiwan. The patients’ 1-year variability in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the baseline and subsequent hip fracture incidence for 8.2 years were analyzed.

Results

There were 937 recorded incident hip fractures. SBP-CV and DBP-CV were classified based on their tertiles. After multivariate adjustment was conducted, SBP-CV found to be a predictor of hip fracture, and its hazard ratio was 1.18 (95% CI 1.00–1.40) for the third tertile compared with the first tertile.

Conclusions

Our study suggests SBP stability is a predictor for hip fracture incidence in older persons with type 2 diabetes.
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Metadata
Title
Visit-to-visit blood pressure variability and hip fracture risk in older persons
Authors
T.-C. Li
C.-I. Li
C.-S. Liu
W.-Y. Lin
C.-H. Lin
S.-Y. Yang
J.-H. Chiang
C.-C. Lin
Publication date
01-04-2019
Publisher
Springer London
Keyword
Type 2 Diabetes
Published in
Osteoporosis International / Issue 4/2019
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-019-04899-7

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