Skip to main content
Top
Published in: BMC Endocrine Disorders 1/2023

Open Access 01-12-2023 | Type 2 Diabetes | Research article

Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada

Authors: Laura C. Rosella, Ednah Negatu, Kathy Kornas, Casey Chu, Limei Zhou, Emmalin Buajitti

Published in: BMC Endocrine Disorders | Issue 1/2023

Login to get access

Abstract

Objective

Individuals with Type 2 Diabetes are likely to experience multimorbidity and accumulate multiple chronic conditions over their life. We aimed to identify causes of death and chronic conditions at the time of death in a population-based cohort, and to analyze variations in the presence of diabetes at the time of death overall and across income and immigrant status.

Research design and methods

We conducted a retrospective cohort study of 2,199,801 adult deaths from 1992 to 2017 in Ontario, Canada. We calculated the proportion of decedents with chronic conditions at time of death and causes of death. The risk of diabetes at the time of death was modeled across sociodemographic variables with a log binomial regression adjusting for sex, age, immigrant status, area-level income. comorbiditiesand time.

Results

The leading causes of death in the cohort were cardiovascular and cancer. Decedents with diabetes had a higher prevalence of most chronic conditions than decedents without diabetes, including hypertension, osteo and other arthritis, chronic coronary syndrome, mood disorder, and congestive heart failure. The risk of diabetes at the time of death was 19% higher in immigrants (95%CI 1.18–1.20) and 15% higher in refugees (95%CI 1.12–1.18) compared to long-term residents, and 19% higher in the lowest income quintile (95%CI 1.18–1.20) relative to the highest income quintile, after adjusting for other covariates.

Conclusions

Individuals with diabetes have a greater multimorbidity burden at the time of death, underscoring the importance of multiple chronic disease management among those living with diabetes and further considerations of the social determinants of health.
Appendix
Available only for authorised users
Literature
1.
go back to reference Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Makaroff LE. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40–50.PubMedCrossRef Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Makaroff LE. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40–50.PubMedCrossRef
2.
go back to reference Fisher K, Griffith L, Gruneir A, Panjwani D, Gandhi S, Sheng LL, Gafni A, Chris P, Markle-Reid M, Ploeg J. Comorbidity and its relationship with health service use and cost in community-living older adults with diabetes: a population-based study in Ontario, Canada. Diabetes Res Clin Pract. 2016;122:113–23.PubMedCrossRef Fisher K, Griffith L, Gruneir A, Panjwani D, Gandhi S, Sheng LL, Gafni A, Chris P, Markle-Reid M, Ploeg J. Comorbidity and its relationship with health service use and cost in community-living older adults with diabetes: a population-based study in Ontario, Canada. Diabetes Res Clin Pract. 2016;122:113–23.PubMedCrossRef
3.
go back to reference Barnett NK, McMurdo MET, Ogston SA, Morris AD, Evans JMM. Mortality in people diagnosed with type 2 diabetes at an older age: a systematic review. Age Ageing. 2006;35(5):463–8.PubMedCrossRef Barnett NK, McMurdo MET, Ogston SA, Morris AD, Evans JMM. Mortality in people diagnosed with type 2 diabetes at an older age: a systematic review. Age Ageing. 2006;35(5):463–8.PubMedCrossRef
5.
go back to reference Zghebi SS, Steinke DT, Rutter MK, Ashcroft DM. Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data. BMJ Open. 2020;10(7):e033866.PubMedCrossRef Zghebi SS, Steinke DT, Rutter MK, Ashcroft DM. Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data. BMJ Open. 2020;10(7):e033866.PubMedCrossRef
6.
go back to reference Nowakowska M, Zghebi SS, Ashcroft DM, Buchan I, Chew-Graham C, Holt T, Mallen C, Van Marwijk H, Peek N, Perera-Salazar R. The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Med. 2019;17(1):145.PubMedPubMedCentralCrossRef Nowakowska M, Zghebi SS, Ashcroft DM, Buchan I, Chew-Graham C, Holt T, Mallen C, Van Marwijk H, Peek N, Perera-Salazar R. The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort. BMC Med. 2019;17(1):145.PubMedPubMedCentralCrossRef
7.
go back to reference Fowler MJ. Microvascular and macrovascular complications of diabetes. Clin Diabetes. 2008;26(2):77–82.CrossRef Fowler MJ. Microvascular and macrovascular complications of diabetes. Clin Diabetes. 2008;26(2):77–82.CrossRef
8.
go back to reference Hermans MP, Dath N. Prevalence and co-prevalence of comorbidities in Belgian patients with type 2 diabetes mellitus: a transversal, descriptive study. Acta Clin Belg. 2018;73(1):68–74.PubMedCrossRef Hermans MP, Dath N. Prevalence and co-prevalence of comorbidities in Belgian patients with type 2 diabetes mellitus: a transversal, descriptive study. Acta Clin Belg. 2018;73(1):68–74.PubMedCrossRef
9.
go back to reference Rao Kondapally Seshasai S, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829–41.PubMedPubMedCentralCrossRef Rao Kondapally Seshasai S, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, et al. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829–41.PubMedPubMedCentralCrossRef
10.
go back to reference Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685–96.PubMedCrossRef Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V, Fuller JH. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685–96.PubMedCrossRef
11.
go back to reference UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317(7160):703–13.PubMedCentralCrossRef UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317(7160):703–13.PubMedCentralCrossRef
12.
go back to reference Vang ZM, Sigouin J, Flenon A, Gagnon A. Are immigrants healthier than native-born Canadians? A systematic review of the healthy immigrant effect in Canada. Ethn Health. 2017;22(3):209–41.PubMedCrossRef Vang ZM, Sigouin J, Flenon A, Gagnon A. Are immigrants healthier than native-born Canadians? A systematic review of the healthy immigrant effect in Canada. Ethn Health. 2017;22(3):209–41.PubMedCrossRef
14.
go back to reference Khan AM, Urquia M, Kornas K, Henry D, Cheng SY, Bornbaum C, Rosella LC. Socioeconomic gradients in all-cause, premature and avoidable mortality among immigrants and long-term residents using linked death records in Ontario, Canada. J Epidemiol Community Health. 2017;71(7):625–32.PubMedCrossRef Khan AM, Urquia M, Kornas K, Henry D, Cheng SY, Bornbaum C, Rosella LC. Socioeconomic gradients in all-cause, premature and avoidable mortality among immigrants and long-term residents using linked death records in Ontario, Canada. J Epidemiol Community Health. 2017;71(7):625–32.PubMedCrossRef
15.
go back to reference Creatore MI, Moineddin R, Booth G, Manuel DH, DesMeules M, McDermott S, Glazier RH. Age- and sex-related prevalence of diabetes mellitus among immigrants to Ontario, Canada. Can Med Assoc J. 2010;182(8):781.CrossRef Creatore MI, Moineddin R, Booth G, Manuel DH, DesMeules M, McDermott S, Glazier RH. Age- and sex-related prevalence of diabetes mellitus among immigrants to Ontario, Canada. Can Med Assoc J. 2010;182(8):781.CrossRef
17.
go back to reference Chiu M, Lebenbaum M, Lam K, Chong N, Azimaee M, Iron K, Manuel D, Guttmann A. Describing the linkages of the immigration, refugees and citizenship Canada permanent resident data and vital statistics death registry to Ontario’s administrative health database. BMC Med Inform Decis Mak. 2016;16(1):135.PubMedPubMedCentralCrossRef Chiu M, Lebenbaum M, Lam K, Chong N, Azimaee M, Iron K, Manuel D, Guttmann A. Describing the linkages of the immigration, refugees and citizenship Canada permanent resident data and vital statistics death registry to Ontario’s administrative health database. BMC Med Inform Decis Mak. 2016;16(1):135.PubMedPubMedCentralCrossRef
18.
go back to reference Hux J, Ivis F, Flintoft V, Bica A. Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm. Diabetes Care. 2002;25:512–6.PubMedCrossRef Hux J, Ivis F, Flintoft V, Bica A. Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm. Diabetes Care. 2002;25:512–6.PubMedCrossRef
19.
go back to reference Gershon AS, Wang C, Guan J, Vasilevska-Ristovska J, Cicutto L, To T. Identifying patients with physician-diagnosed asthma in health administrative databases. Can Respir J. 2009;16(6):183–8.PubMedPubMedCentralCrossRef Gershon AS, Wang C, Guan J, Vasilevska-Ristovska J, Cicutto L, To T. Identifying patients with physician-diagnosed asthma in health administrative databases. Can Respir J. 2009;16(6):183–8.PubMedPubMedCentralCrossRef
20.
go back to reference Hall S, Schulze K, Groome P, MacKillop W, Holowaty E. Using cancer registry data for survival studies: the example of the Ontario Cancer Registry. J Clin Epdemiol. 2006;59(1):67–76.CrossRef Hall S, Schulze K, Groome P, MacKillop W, Holowaty E. Using cancer registry data for survival studies: the example of the Ontario Cancer Registry. J Clin Epdemiol. 2006;59(1):67–76.CrossRef
21.
go back to reference Schultz S, Rothwell D, Chen Z, Tu K. Identifying cases of congestive heart failure from administrative data: a validation study using primary care patient records. Chronic Dis Inj Can. 2013;33(3):160–6.PubMedCrossRef Schultz S, Rothwell D, Chen Z, Tu K. Identifying cases of congestive heart failure from administrative data: a validation study using primary care patient records. Chronic Dis Inj Can. 2013;33(3):160–6.PubMedCrossRef
22.
go back to reference Gershon A, Wang C, Guan J, Vasilevska-Ristovska J, Cicutto L, To T. Identifying individuals with physcian diagnosed COPD in health administrative databases. COPD. 2009;6(5):388–94.PubMedCrossRef Gershon A, Wang C, Guan J, Vasilevska-Ristovska J, Cicutto L, To T. Identifying individuals with physcian diagnosed COPD in health administrative databases. COPD. 2009;6(5):388–94.PubMedCrossRef
23.
go back to reference Widdifield J, Bernatsky S, Paterson JM, Tu K, Ng R, Thorne JC, Pope JE, Bombardier C. Accuracy of Canadian health administrative databases in identifying patients with rheumatoid arthritis: a validation study using the medical records of rheumatologists. Arthritis Care Res. 2013;65(10):1582–91. Widdifield J, Bernatsky S, Paterson JM, Tu K, Ng R, Thorne JC, Pope JE, Bombardier C. Accuracy of Canadian health administrative databases in identifying patients with rheumatoid arthritis: a validation study using the medical records of rheumatologists. Arthritis Care Res. 2013;65(10):1582–91.
24.
go back to reference Tu K, Campbell NR, Chen ZL, Cauch-Dudek KJ, McAlister FA. Accuracy of administrative databases in identifying patients with hypertension. Open Med. 2007;1(1):e18–26.PubMedPubMedCentral Tu K, Campbell NR, Chen ZL, Cauch-Dudek KJ, McAlister FA. Accuracy of administrative databases in identifying patients with hypertension. Open Med. 2007;1(1):e18–26.PubMedPubMedCentral
25.
go back to reference Benchimol EI, Guttmann A, Mack DR, Nguyen GC, Marshall JK, Gregor JC, Wong J, Forster AJ, Manuel DG. Validation of international algorithms to identify adults with inflammatory bowel disease in health administrative data from Ontario, Canada. J Clin Epidemiol. 2014;67(8):887–96.PubMedCrossRef Benchimol EI, Guttmann A, Mack DR, Nguyen GC, Marshall JK, Gregor JC, Wong J, Forster AJ, Manuel DG. Validation of international algorithms to identify adults with inflammatory bowel disease in health administrative data from Ontario, Canada. J Clin Epidemiol. 2014;67(8):887–96.PubMedCrossRef
26.
go back to reference Weiner JP, Starfield BH, Steinwachs DM, Mumford LM. Development and application of a population-oriented measure of ambulatory care case-mix. Med Care. 1991;29(5):452–72.PubMedCrossRef Weiner JP, Starfield BH, Steinwachs DM, Mumford LM. Development and application of a population-oriented measure of ambulatory care case-mix. Med Care. 1991;29(5):452–72.PubMedCrossRef
27.
go back to reference Nolte E, McKee M. Measuring the health of nations: analysis of mortality amenable to health care. J Epidemiol Community Health. 2004;58(4):326–326.PubMedCentral Nolte E, McKee M. Measuring the health of nations: analysis of mortality amenable to health care. J Epidemiol Community Health. 2004;58(4):326–326.PubMedCentral
28.
go back to reference Plug I, Hoffmann R, Artnik B, Bopp M, Borrell C, Costa G, Deboosere P, Esnaola S, Kalediene R, Leinsalu M. Socioeconomic inequalities in mortality from conditions amenable to medical interventions: do they reflect inequalities in access or quality of health care? BMC Public Health. 2012;12(1):346.PubMedPubMedCentralCrossRef Plug I, Hoffmann R, Artnik B, Bopp M, Borrell C, Costa G, Deboosere P, Esnaola S, Kalediene R, Leinsalu M. Socioeconomic inequalities in mortality from conditions amenable to medical interventions: do they reflect inequalities in access or quality of health care? BMC Public Health. 2012;12(1):346.PubMedPubMedCentralCrossRef
29.
go back to reference James P, Wilkins R, Detsky A, Tugwell P, Manuel D. Avoidable mortality by neighbourhood income in Canada: 25 years after the establishment of universal health insurance. J Epidemiol Community Health. 2007;61:287–96.PubMedPubMedCentralCrossRef James P, Wilkins R, Detsky A, Tugwell P, Manuel D. Avoidable mortality by neighbourhood income in Canada: 25 years after the establishment of universal health insurance. J Epidemiol Community Health. 2007;61:287–96.PubMedPubMedCentralCrossRef
30.
go back to reference Roche MM, Wang PP. Sex differences in all-cause and cardiovascular mortality, hospitalization for individuals with and without diabetes, and patients with diabetes diagnosed early and late. Diabetes Care. 2013;36(9):2582.PubMedPubMedCentralCrossRef Roche MM, Wang PP. Sex differences in all-cause and cardiovascular mortality, hospitalization for individuals with and without diabetes, and patients with diabetes diagnosed early and late. Diabetes Care. 2013;36(9):2582.PubMedPubMedCentralCrossRef
31.
go back to reference Roper NA, Bilous RW, Kelly WF, Unwin NC, Connolly VM. Cause-specific mortality in a population with diabetes. Diabetes Care. 2002;25(1):43.PubMedCrossRef Roper NA, Bilous RW, Kelly WF, Unwin NC, Connolly VM. Cause-specific mortality in a population with diabetes. Diabetes Care. 2002;25(1):43.PubMedCrossRef
32.
go back to reference Harding JL, Andes LJ, Gregg EW, Cheng YJ, Weir HK, Bullard KM, Burrows NR, Imperatore G. Trends in cancer mortality among people with vs without diabetes in the USA, 1988–2015. Diabetologia. 2020;63(1):75–84.PubMedCrossRef Harding JL, Andes LJ, Gregg EW, Cheng YJ, Weir HK, Bullard KM, Burrows NR, Imperatore G. Trends in cancer mortality among people with vs without diabetes in the USA, 1988–2015. Diabetologia. 2020;63(1):75–84.PubMedCrossRef
33.
go back to reference Harding JL, Shaw JE, Peeters A, Guiver T, Davidson S, Magliano DJ. Mortality trends among people with type 1 and type 2 diabetes in Australia: 1997–2010. Diabetes Care. 2014;37(9):2579–86.PubMedCrossRef Harding JL, Shaw JE, Peeters A, Guiver T, Davidson S, Magliano DJ. Mortality trends among people with type 1 and type 2 diabetes in Australia: 1997–2010. Diabetes Care. 2014;37(9):2579–86.PubMedCrossRef
34.
go back to reference Harjutsalo V, Forsblom C, Groop P-H. Time trends in mortality in patients with type 1 diabetes: nationwide population based cohort study. BMJ. 2011;343:d5364.PubMedPubMedCentralCrossRef Harjutsalo V, Forsblom C, Groop P-H. Time trends in mortality in patients with type 1 diabetes: nationwide population based cohort study. BMJ. 2011;343:d5364.PubMedPubMedCentralCrossRef
35.
go back to reference Kim D, Li AA, Cholankeril G, Kim SH, Ingelsson E, Knowles JW, Harrington RA, Ahmed A. Trends in overall, cardiovascular and cancer-related mortality among individuals with diabetes reported on death certificates in the United States between 2007 and 2017. Diabetologia. 2019;62(7):1185–94.PubMedPubMedCentralCrossRef Kim D, Li AA, Cholankeril G, Kim SH, Ingelsson E, Knowles JW, Harrington RA, Ahmed A. Trends in overall, cardiovascular and cancer-related mortality among individuals with diabetes reported on death certificates in the United States between 2007 and 2017. Diabetologia. 2019;62(7):1185–94.PubMedPubMedCentralCrossRef
36.
go back to reference Tsunekawa S, Kamiya H, Nakamura J. Different trends in causes of death in patients with diabetes between Japan and the USA. J Diabetes Investig. 2019;10(3):571–3.PubMedCrossRef Tsunekawa S, Kamiya H, Nakamura J. Different trends in causes of death in patients with diabetes between Japan and the USA. J Diabetes Investig. 2019;10(3):571–3.PubMedCrossRef
37.
go back to reference Lind M, Garcia-Rodriguez LA, Booth GL, Cea-Soriano L, Shah BR, Ekeroth G, Lipscombe LL. Mortality trends in patients with and without diabetes in Ontario, Canada and the UK from 1996 to 2009: a population-based study. Diabetologia. 2013;56(12):2601–8.PubMedCrossRef Lind M, Garcia-Rodriguez LA, Booth GL, Cea-Soriano L, Shah BR, Ekeroth G, Lipscombe LL. Mortality trends in patients with and without diabetes in Ontario, Canada and the UK from 1996 to 2009: a population-based study. Diabetologia. 2013;56(12):2601–8.PubMedCrossRef
38.
go back to reference Tancredi M, Rosengren A, Svensson A-M, Kosiborod M, Pivodic A, Gudbjörnsdottir S, Wedel H, Clements M, Dahlqvist S, Lind M. Excess mortality among persons with type 2 diabetes. N Engl J Med. 2015;373(18):1720–32.PubMedCrossRef Tancredi M, Rosengren A, Svensson A-M, Kosiborod M, Pivodic A, Gudbjörnsdottir S, Wedel H, Clements M, Dahlqvist S, Lind M. Excess mortality among persons with type 2 diabetes. N Engl J Med. 2015;373(18):1720–32.PubMedCrossRef
39.
go back to reference Tachkov K, Mitov K, Koleva Y, Mitkova Z, Kamusheva M, Dimitrova M, Petkova V, Savova A, Doneva M, Tcarukciev D, et al. Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria. PLoS One. 2020;15(5):e0232815.PubMedPubMedCentralCrossRef Tachkov K, Mitov K, Koleva Y, Mitkova Z, Kamusheva M, Dimitrova M, Petkova V, Savova A, Doneva M, Tcarukciev D, et al. Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria. PLoS One. 2020;15(5):e0232815.PubMedPubMedCentralCrossRef
40.
go back to reference Khan AM, Urquia M, Kornas K, Henry D, Cheng SY, Bornbaum C, Rosella LC. Socioeconomic gradients in all-cause, premature and avoidable mortality among immigrants and long-term residents using linked death records in Ontario, Canada. J Epidemiol Community Health. 2017. https://doi.org/10.1136/jech-2016-208525. Khan AM, Urquia M, Kornas K, Henry D, Cheng SY, Bornbaum C, Rosella LC. Socioeconomic gradients in all-cause, premature and avoidable mortality among immigrants and long-term residents using linked death records in Ontario, Canada. J Epidemiol Community Health. 2017. https://​doi.​org/​10.​1136/​jech-2016-208525.
41.
go back to reference Dinca-Panaitescu S, Dinca-Panaitescu M, Bryant T, Daiski I, Pilkington B, Raphael D. Diabetes prevalence and income: results of the Canadian Community Health Survey. Health Policy. 2011;99(2):116–23.PubMedCrossRef Dinca-Panaitescu S, Dinca-Panaitescu M, Bryant T, Daiski I, Pilkington B, Raphael D. Diabetes prevalence and income: results of the Canadian Community Health Survey. Health Policy. 2011;99(2):116–23.PubMedCrossRef
42.
go back to reference Rosella L, Kornas K. Putting a population health lens to multimorbidity in Ontario. Healthc Q. 2018;21(3):8–11.PubMedCrossRef Rosella L, Kornas K. Putting a population health lens to multimorbidity in Ontario. Healthc Q. 2018;21(3):8–11.PubMedCrossRef
43.
go back to reference Kastner M, Cardoso R, Lai Y, Treister V, Hamid JS, Hayden L, Wong G, Ivers NM, Liu B, Marr S. Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis. CMAJ. 2018;190(34):E1004–12.PubMedPubMedCentralCrossRef Kastner M, Cardoso R, Lai Y, Treister V, Hamid JS, Hayden L, Wong G, Ivers NM, Liu B, Marr S. Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis. CMAJ. 2018;190(34):E1004–12.PubMedPubMedCentralCrossRef
44.
go back to reference Buajitti E, Chiodo S, Rosella LC. Agreement between area-and individual-level income measures in a population-based cohort: Implications for population health research. SSM Popul Health. 2020;10:100553.PubMedPubMedCentralCrossRef Buajitti E, Chiodo S, Rosella LC. Agreement between area-and individual-level income measures in a population-based cohort: Implications for population health research. SSM Popul Health. 2020;10:100553.PubMedPubMedCentralCrossRef
Metadata
Title
Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
Authors
Laura C. Rosella
Ednah Negatu
Kathy Kornas
Casey Chu
Limei Zhou
Emmalin Buajitti
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Type 2 Diabetes
Published in
BMC Endocrine Disorders / Issue 1/2023
Electronic ISSN: 1472-6823
DOI
https://doi.org/10.1186/s12902-023-01362-x

Other articles of this Issue 1/2023

BMC Endocrine Disorders 1/2023 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine