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International Journal of Diabetes in Developing Countries

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01-04-2020 | Type 2 Diabetes | Original Article

MACF1 gene variant rs2296172 is associated with T2D susceptibility in Mizo population from Northeast India

Authors: Freda Lalrohlui, Varun Sharma, Indu Sharma, Hemender Singh, Guneet Kour, Surbhi Sharma, Yuman, John Zohmingthanga, Vanlalhruaii, Ekta Rai, Vinod Singh, Nachimuthu Senthil Kumar, Swarkar Sharma

Published in: International Journal of Diabetes in Developing Countries | Issue 2/2020

Abstract

Aim

Microtubule actin cross-linking factor 1 (MACF1) has been identified as a type 2 diabetes (T2D) candidate gene, and variant rs2296172 of the gene was found associated with T2D in multiple populations. However, it has never been explored in Mizo population. The aim of the present study was to replicate the association of variant rs2296172 of MACF1 gene with T2D in Mizo population of Northeast India.

Methodology

The variation was genotyped using TaqMan allele discrimination assay in 755 individuals (425 cases and 330 healthy controls), belonging to the Mizo population.

Results

The variant rs2296172 MACF1 was found to be significantly associated with T2D (p value = 0.001) in Mizo population group with an observed odds ratio of 1.8 [1.3–2.8] at 95% CI after correction with age, gender and BMI.

Conclusion

This study is the first replication report from Northeast India, showing variant rs2296172 of MACF1 gene associated with T2D in Mizo population. This independent study highlights MACF1 as a candidate gene for T2D in Asian Indian populations, suggesting it is critical to evaluate the variant rs2296172 in other distinct endogamous Indian population cohorts.

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Title: MACF1 gene variant rs2296172 is associated with T2D susceptibility in Mizo population from Northeast India
Authors: Freda Lalrohlui
Varun Sharma
Indu Sharma
Hemender Singh
Guneet Kour
Surbhi Sharma
Yuman
John Zohmingthanga
Vanlalhruaii
Ekta Rai
Vinod Singh
Nachimuthu Senthil Kumar
Swarkar Sharma
Publication date: 01-04-2020
Publisher: Springer India
Keyword: Type 2 Diabetes
Published in: International Journal of Diabetes in Developing Countries / Issue 2/2020
Print ISSN: 0973-3930
Electronic ISSN: 1998-3832
DOI: https://doi.org/10.1007/s13410-019-00788-1

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Abstract

Aim

Methodology

Results

Conclusion

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