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Open Access 01-09-2020 | Type 2 Diabetes | Original Article

Is there an association between serum 25(OH)D₃ and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care

Authors: Maria Samefors, Robert Scragg, Fredrik H. Nystrom, Carl Johan Östgren

Published in: Hormones | Issue 3/2020

Abstract

Purpose

There are limited and inconsistent results on the correlation between vitamin D and mental health in patients with type 2 diabetes (T2D). Thus, our aim was to explore the association between vitamin D and mental well-being in a community-based sample of participants with T2D.

Methods

We analyzed serum 25-hydroxyvitamin D₃ (25(OH)D₃) in 698 patients with T2D at the baseline examination. The cohort was reinvestigated after 4 years. Data from SF-36 questionnaires measuring vitality and mental health at baseline and after 4 years were used for analyses.

Results

Serum 25(OH)D₃ was inversely associated with poor mental health at baseline (odds ratio (OR) for 10 nmol/l increase in 25(OH)D₃, 0.90 (95% confidence interval (CI) 0.83–0.96, p = 0.003)) but not at follow-up (p > 0.05). Serum 25(OH)D₃ was not associated with vitality at baseline (p > 0.05). At follow-up, there was an inverse association between 25(OH)D₃ and low vitality (OR for 10 nmol/l increase in 25(OH)D₃, 0.89 (95% CI 0.82–0.97, p = 0.009)) but not after adjustment.

Conclusion

We found an inverse association between 25(OH)D₃ and mental health in patients with T2D at baseline. We found no association between 25(OH)D₃ and vitality after adjustment. Future studies are needed to determine the association between vitamin D and mental well-being in patients with T2D.

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Title: Is there an association between serum 25(OH)D3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care
Authors: Maria Samefors
Robert Scragg
Fredrik H. Nystrom
Carl Johan Östgren
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keyword: Type 2 Diabetes
Published in: Hormones / Issue 3/2020
Print ISSN: 1109-3099
Electronic ISSN: 2520-8721
DOI: https://doi.org/10.1007/s42000-020-00190-1

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