Skip to main content
Top
Published in: European Archives of Psychiatry and Clinical Neuroscience 3/2008

01-04-2008 | ORIGINAL PAPER

Type 2 diabetes among persons with schizophrenia and other psychotic disorders in a general population survey

Authors: Jaana Suvisaari, MD, PhD, Jonna Perälä, MD, Samuli I. Saarni, MD, MSocSc, Tommi Härkänen, PhD, Sami Pirkola, MD, PhD, Matti Joukamaa, MD, PhD, Seppo Koskinen, MD, PhD, MSc, Jouko Lönnqvist, MD, PhD, Antti Reunanen, MD, PhD

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2008

Login to get access

Abstract

Schizophrenia and other psychotic disorders are associated with increased risk of developing type 2 diabetes. However, previous studies are mainly based on clinical samples where the comorbidity may be stronger. We investigated in a general population survey the prevalence of type 2 diabetes in persons with psychotic disorders and in users of antipsychotic medication. The study was based on a nationally representative two-stage cluster sample of 8,028 persons aged 30 or over from Finland. Diagnostic assessment of psychotic disorders combined SCID-I interview and case note data. Prevalences of type 2 diabetes, adjusting for age and sex, were estimated by calculating predicted marginals. The prevalence estimate of type 2 diabetes was 22.0% among subjects with schizophrenia, 13.4% among subjects with other nonaffective psychosis and 6.1% in subjects without psychotic disorders. Only two subjects (3.4%) with affective psychosis had type 2 diabetes. Users of all types of antipsychotic medication had increased prevalence of type 2 diabetes. Our results suggest that type 2 diabetes is a major health concern among persons with schizophrenia and other nonaffective psychotic disorders and also in users of antipsychotic medication, but persons with affective psychosis in the general population may not have increased prevalence of type 2 diabetes.
Literature
1.
go back to reference Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686–1696PubMed Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686–1696PubMed
3.
go back to reference Arranz B, Rosel P, Ramírez N, Dueñas R, Fernández P, Sanchez JM, Navarro MA, San L (2004) Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients. J Clin Psychiatry 65:1335–1342PubMed Arranz B, Rosel P, Ramírez N, Dueñas R, Fernández P, Sanchez JM, Navarro MA, San L (2004) Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients. J Clin Psychiatry 65:1335–1342PubMed
4.
go back to reference Bellivier F (2005) Schizophrenia, antipsychotics and diabetes: genetic aspects. Eur Psychiatry 20:S335–S339PubMedCrossRef Bellivier F (2005) Schizophrenia, antipsychotics and diabetes: genetic aspects. Eur Psychiatry 20:S335–S339PubMedCrossRef
5.
go back to reference Brown S, Birtwistle J, Roe L, Thompson C (1999) The unhealthy lifestyle of people with schizophrenia. Psychol Med 29:697–701PubMedCrossRef Brown S, Birtwistle J, Roe L, Thompson C (1999) The unhealthy lifestyle of people with schizophrenia. Psychol Med 29:697–701PubMedCrossRef
6.
go back to reference Cassidy F, Ahearn E, Carroll BJ (1999) Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients. Am J Psychiatry 156:1417–1420PubMed Cassidy F, Ahearn E, Carroll BJ (1999) Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients. Am J Psychiatry 156:1417–1420PubMed
7.
go back to reference Cohen D, Grobbee DE, Stolk RP, Gispen-De-Wied CC (2006) Hyperglycemia and diabetes in patients with schizophrenia or schizoaffective disorder. Diabetes Care 29:786–791PubMedCrossRef Cohen D, Grobbee DE, Stolk RP, Gispen-De-Wied CC (2006) Hyperglycemia and diabetes in patients with schizophrenia or schizoaffective disorder. Diabetes Care 29:786–791PubMedCrossRef
8.
go back to reference Cohn T, Prud’homme D, Streiner D, Kameh H, Remington G (2004) Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome. Can J Psychiatry 49:753–760PubMed Cohn T, Prud’homme D, Streiner D, Kameh H, Remington G (2004) Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome. Can J Psychiatry 49:753–760PubMed
9.
go back to reference De Hert M, van Winkel R, Van Eyck D, Hanssens L, Wampers M, Scheen A, Peuskens J (2006) Prevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study. Clin Pract Epidemol Ment Health 2:14PubMedCrossRef De Hert M, van Winkel R, Van Eyck D, Hanssens L, Wampers M, Scheen A, Peuskens J (2006) Prevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study. Clin Pract Epidemol Ment Health 2:14PubMedCrossRef
10.
go back to reference De Hert MA, van Winkel R, Van Eyck D, Hanssens L, Wampers M, Scheen A, Peuskens J (2006) Prevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medication. Schizophr Res 83:87–93PubMedCrossRef De Hert MA, van Winkel R, Van Eyck D, Hanssens L, Wampers M, Scheen A, Peuskens J (2006) Prevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medication. Schizophr Res 83:87–93PubMedCrossRef
11.
go back to reference Dixon L, Weiden P, Delahanty J, Goldberg R, Postrado L, Lucksted A, Lehman A (2000) Prevalence and correlates of diabetes in national schizophrenia samples. Schizophr Bull 26:903–912PubMed Dixon L, Weiden P, Delahanty J, Goldberg R, Postrado L, Lucksted A, Lehman A (2000) Prevalence and correlates of diabetes in national schizophrenia samples. Schizophr Bull 26:903–912PubMed
12.
go back to reference Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults (2001) Executive summary of The Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285:2486–2497CrossRef Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults (2001) Executive summary of The Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285:2486–2497CrossRef
13.
go back to reference Gianfrancesco F, Grogg A, Mahmoud R, Wang R-H, Meletiche D (2003) Differential effects of antipsychotic agents on the risk of development of type 2 diabetes mellitus in patients with mood disorders. Clin Ther 25:1150–1171PubMedCrossRef Gianfrancesco F, Grogg A, Mahmoud R, Wang R-H, Meletiche D (2003) Differential effects of antipsychotic agents on the risk of development of type 2 diabetes mellitus in patients with mood disorders. Clin Ther 25:1150–1171PubMedCrossRef
14.
go back to reference Goff DC, Sullivan LM, McEvoy JP, Meyer JM, Nasrallah HA, Daumit GL, Lamberti S, D’Agostino RB, Stroup TS, Davis S, Lieberman JA (2005) A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls. Schizophr Res 80:45–53PubMedCrossRef Goff DC, Sullivan LM, McEvoy JP, Meyer JM, Nasrallah HA, Daumit GL, Lamberti S, D’Agostino RB, Stroup TS, Davis S, Lieberman JA (2005) A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls. Schizophr Res 80:45–53PubMedCrossRef
15.
go back to reference Gough SC, O’Donovan MC (2005) Clustering of metabolic comorbidity in schizophrenia: a genetic contribution? J Psychopharmacol 19(6 Suppl):47–55PubMedCrossRef Gough SC, O’Donovan MC (2005) Clustering of metabolic comorbidity in schizophrenia: a genetic contribution? J Psychopharmacol 19(6 Suppl):47–55PubMedCrossRef
16.
go back to reference Heistaro S (ed) (2005) Menetelmäraportti. Terveys 2000 -tutkimuksen toteutus, aineisto ja menetelmät (Implementation, data and methods of the Health 2000 Survey, in Finnish). Publications of the National Public Health Institute, B6 Heistaro S (ed) (2005) Menetelmäraportti. Terveys 2000 -tutkimuksen toteutus, aineisto ja menetelmät (Implementation, data and methods of the Health 2000 Survey, in Finnish). Publications of the National Public Health Institute, B6
17.
go back to reference Henderson DC, Cagliero E, Gray C, Nasrallah RA, Hayden DL, Schoenfeld DA, Goff DC (2000) Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic study. Am J Psychiatry 157:975–981PubMedCrossRef Henderson DC, Cagliero E, Gray C, Nasrallah RA, Hayden DL, Schoenfeld DA, Goff DC (2000) Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: A five-year naturalistic study. Am J Psychiatry 157:975–981PubMedCrossRef
18.
go back to reference Henderson DC, Cagliero E, Copeland PM, Borba CP, Evins E, Hayden D, Weber MT, Anderson EJ, Allison DB, Daley TB, Schoenfeld D, Goff DC (2005) Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents. Arch Gen Psychiatry 62:19–28PubMedCrossRef Henderson DC, Cagliero E, Copeland PM, Borba CP, Evins E, Hayden D, Weber MT, Anderson EJ, Allison DB, Daley TB, Schoenfeld D, Goff DC (2005) Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents. Arch Gen Psychiatry 62:19–28PubMedCrossRef
19.
go back to reference Hung C-F, Wu C-K, Lin P-Y (2005) Diabetes mellitus in patients with schizophrenia in Taiwan. Prog Neuro-Psychopharmacol Biol Psychiatry 29:523–527CrossRef Hung C-F, Wu C-K, Lin P-Y (2005) Diabetes mellitus in patients with schizophrenia in Taiwan. Prog Neuro-Psychopharmacol Biol Psychiatry 29:523–527CrossRef
20.
go back to reference Jin H, Meyer JM, Jeste DV (2004) Atypical antipsychotics and glucose dysregulation: a systematic review. Schizophr Res 71:195–212PubMedCrossRef Jin H, Meyer JM, Jeste DV (2004) Atypical antipsychotics and glucose dysregulation: a systematic review. Schizophr Res 71:195–212PubMedCrossRef
21.
go back to reference Kilbourne AM, Cornelius JR, Han X, Haas GL, Salloum I, Conigliaro J, Pincus HA (2005) General-medical conditions in older patients with serious mental illness. Am J Geriatr Psychiatry 13:250–254PubMedCrossRef Kilbourne AM, Cornelius JR, Han X, Haas GL, Salloum I, Conigliaro J, Pincus HA (2005) General-medical conditions in older patients with serious mental illness. Am J Geriatr Psychiatry 13:250–254PubMedCrossRef
22.
go back to reference Koponen H, Saari K, Savolainen M, Isohanni M (2002) Weight gain and glucose and lipid metabolism disturbances during antipsychotic medication. Eur Arch Psychiatry Clin Neurosci 252:294–298PubMedCrossRef Koponen H, Saari K, Savolainen M, Isohanni M (2002) Weight gain and glucose and lipid metabolism disturbances during antipsychotic medication. Eur Arch Psychiatry Clin Neurosci 252:294–298PubMedCrossRef
24.
25.
go back to reference Lamberti JS, Crilly JF, Maharaj K, Olson D, Wiener K, Dvorin S, Costea GO, Bushey MP, Dietz MB (2004) Prevalence of diabetes mellitus among outpatients with severe mental disorders receiving atypical antipsychotic drugs. J Clin Psychiatry 65:702–706PubMedCrossRef Lamberti JS, Crilly JF, Maharaj K, Olson D, Wiener K, Dvorin S, Costea GO, Bushey MP, Dietz MB (2004) Prevalence of diabetes mellitus among outpatients with severe mental disorders receiving atypical antipsychotic drugs. J Clin Psychiatry 65:702–706PubMedCrossRef
26.
go back to reference Lazarus R, Sparrow D, Weiss ST (1997) Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative Aging Study. Metabolism 46:1266–1269PubMedCrossRef Lazarus R, Sparrow D, Weiss ST (1997) Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative Aging Study. Metabolism 46:1266–1269PubMedCrossRef
27.
go back to reference Lee J (1981) Covariance adjustment of rates based on the multiple logistic regression model. J Chronic Dis 34:415–426PubMedCrossRef Lee J (1981) Covariance adjustment of rates based on the multiple logistic regression model. J Chronic Dis 34:415–426PubMedCrossRef
28.
go back to reference Leslie DL, Rosenheck RA (2004) Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications. Am J Psychiatry 161:1709–1711PubMedCrossRef Leslie DL, Rosenheck RA (2004) Incidence of newly diagnosed diabetes attributable to atypical antipsychotic medications. Am J Psychiatry 161:1709–1711PubMedCrossRef
29.
go back to reference Lindenmayer J-P, Czobor P, Volavka J, Citrome L, Sheitman B, McEvoy JP, Cooper TB, Chakos M, Lieberman JA (2003) Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics. Am J Psychiatry 160:290–296PubMedCrossRef Lindenmayer J-P, Czobor P, Volavka J, Citrome L, Sheitman B, McEvoy JP, Cooper TB, Chakos M, Lieberman JA (2003) Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics. Am J Psychiatry 160:290–296PubMedCrossRef
30.
go back to reference Montonen J, Knekt P, Harkanen T, Jarvinen R, Heliovaara M, Aromaa A, Reunanen A (2005) Dietary patterns and the incidence of type 2 diabetes. Am J Epidemiol 161:219–227PubMedCrossRef Montonen J, Knekt P, Harkanen T, Jarvinen R, Heliovaara M, Aromaa A, Reunanen A (2005) Dietary patterns and the incidence of type 2 diabetes. Am J Epidemiol 161:219–227PubMedCrossRef
31.
go back to reference Mukherjee S, Decina P, Bocola V, Saraceni F, Scapicchio P (1996) Diabetes mellitus in schizophrenic patients. Compr Psychiatry 37:68–73PubMedCrossRef Mukherjee S, Decina P, Bocola V, Saraceni F, Scapicchio P (1996) Diabetes mellitus in schizophrenic patients. Compr Psychiatry 37:68–73PubMedCrossRef
32.
go back to reference Nasrallah H, Meyer JM, Goff DC, McEvoy JP, Davis SM, Stroup TS, Lieberman JA (2006) Low rates of treatment for hypertension, dyslipidemia and diabetes in schizophrenia: Data from the CATIE schizophrenia trial sample at baseline. Schizophr Res 86:15–22PubMedCrossRef Nasrallah H, Meyer JM, Goff DC, McEvoy JP, Davis SM, Stroup TS, Lieberman JA (2006) Low rates of treatment for hypertension, dyslipidemia and diabetes in schizophrenia: Data from the CATIE schizophrenia trial sample at baseline. Schizophr Res 86:15–22PubMedCrossRef
33.
go back to reference National Agency for Medicines and Social Insurance Institution (2005) Finnish Statistics on Medicines 2004. Edita Prima Oy, Helsinki National Agency for Medicines and Social Insurance Institution (2005) Finnish Statistics on Medicines 2004. Edita Prima Oy, Helsinki
34.
go back to reference National Agency for Medicines and Social Insurance Institution (2001) Finnish Statistics on Medicines 2000. Edita Oy, Helsinki National Agency for Medicines and Social Insurance Institution (2001) Finnish Statistics on Medicines 2000. Edita Oy, Helsinki
35.
go back to reference Newcomer JW, Haupt DW, Fucetola R, Melson AK, Schweiger JA, Cooper BP, Selke G (2002) Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry 59:337–345PubMedCrossRef Newcomer JW, Haupt DW, Fucetola R, Melson AK, Schweiger JA, Cooper BP, Selke G (2002) Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry 59:337–345PubMedCrossRef
36.
go back to reference Patja K, Jousilahti P, Hu G, Valle T, Qiao Q, Tuomilehto J (2005) Effects of smoking, obesity and physical activity on the risk of type 2 diabetes in middle-aged Finnish men and women. J Intern Med 258:356–362PubMedCrossRef Patja K, Jousilahti P, Hu G, Valle T, Qiao Q, Tuomilehto J (2005) Effects of smoking, obesity and physical activity on the risk of type 2 diabetes in middle-aged Finnish men and women. J Intern Med 258:356–362PubMedCrossRef
37.
go back to reference Perälä J, Suvisaari J, Saarni SI, Kuoppasalmi K, Isometsä E, Pirkola S, Partonen T, Tuulio-Henriksson A, Hintikka J, Kieseppä T, Härkänen T, Koskinen S, Lönnqvist J (2007) Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry 64:19–28PubMedCrossRef Perälä J, Suvisaari J, Saarni SI, Kuoppasalmi K, Isometsä E, Pirkola S, Partonen T, Tuulio-Henriksson A, Hintikka J, Kieseppä T, Härkänen T, Koskinen S, Lönnqvist J (2007) Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry 64:19–28PubMedCrossRef
38.
go back to reference Philippe A, Vaiva G, Casadebaig F (2005) Data on diabetes from the French cohort study in schizophrenia. Eur Psychiatry 20:S340–S344PubMedCrossRef Philippe A, Vaiva G, Casadebaig F (2005) Data on diabetes from the French cohort study in schizophrenia. Eur Psychiatry 20:S340–S344PubMedCrossRef
39.
go back to reference Pierce M, Keen H, Bradley C (1995) Risk of diabetes in offspring of parents with non-insulin-dependent diabetes. Diabet Med 12:6–13PubMedCrossRef Pierce M, Keen H, Bradley C (1995) Risk of diabetes in offspring of parents with non-insulin-dependent diabetes. Diabet Med 12:6–13PubMedCrossRef
40.
go back to reference Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV (2002) Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. J Affect Disord 70:19–26PubMedCrossRef Regenold WT, Thapar RK, Marano C, Gavirneni S, Kondapavuluru PV (2002) Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. J Affect Disord 70:19–26PubMedCrossRef
41.
go back to reference Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Diabetes Care 20:1183–1197 Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Diabetes Care 20:1183–1197
42.
go back to reference Research Triangle Institute (2004) SUDAAN Language Manual, Release 9.0. Research Triangle Park, NC: Research Triangle Institute Research Triangle Institute (2004) SUDAAN Language Manual, Release 9.0. Research Triangle Park, NC: Research Triangle Institute
43.
go back to reference Ryan MCM, Collins P, Thakore JH (2003) Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Am J Psychiatry 160:284–289PubMedCrossRef Ryan MCM, Collins P, Thakore JH (2003) Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia. Am J Psychiatry 160:284–289PubMedCrossRef
44.
go back to reference Stewart R, Liolitsa D (1999) Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med 16:93–112PubMedCrossRef Stewart R, Liolitsa D (1999) Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med 16:93–112PubMedCrossRef
45.
go back to reference Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333–1346PubMedCrossRef Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333–1346PubMedCrossRef
46.
go back to reference Subramaniam M, Chong S-A, Pek E (2003) Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia. Can J Psychiatry 48:345–347PubMed Subramaniam M, Chong S-A, Pek E (2003) Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia. Can J Psychiatry 48:345–347PubMed
47.
go back to reference Susce MT, Villanueva N, Diaz FJ, de Leon J (2005) Obesity and associated complication in patients with severe mental illnesses: a cross-sectional survey. J Clin Psychiatry 66:167–173PubMed Susce MT, Villanueva N, Diaz FJ, de Leon J (2005) Obesity and associated complication in patients with severe mental illnesses: a cross-sectional survey. J Clin Psychiatry 66:167–173PubMed
48.
go back to reference van Winkel R, De Hert M, Van Eyck D, Hanssens L, Wampers M, Scheen A, Peuskens J (2006) Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: Evaluation of incidence and screening methods. J Clin Psychiatry 67:1493–1500PubMedCrossRef van Winkel R, De Hert M, Van Eyck D, Hanssens L, Wampers M, Scheen A, Peuskens J (2006) Screening for diabetes and other metabolic abnormalities in patients with schizophrenia and schizoaffective disorder: Evaluation of incidence and screening methods. J Clin Psychiatry 67:1493–1500PubMedCrossRef
49.
go back to reference Weiss AP, Henderson DC, Weiburg JB, Goff DC, Meigs JB, Cagliero E, Grant RW (2006) Treatment of cardiac risk factors among patients with schizophrenia and diabetes. Psychiatr Serv 57:1145–1152PubMedCrossRef Weiss AP, Henderson DC, Weiburg JB, Goff DC, Meigs JB, Cagliero E, Grant RW (2006) Treatment of cardiac risk factors among patients with schizophrenia and diabetes. Psychiatr Serv 57:1145–1152PubMedCrossRef
50.
go back to reference World Health Organization Expert Committee (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation, part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organization World Health Organization Expert Committee (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation, part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organization
Metadata
Title
Type 2 diabetes among persons with schizophrenia and other psychotic disorders in a general population survey
Authors
Jaana Suvisaari, MD, PhD
Jonna Perälä, MD
Samuli I. Saarni, MD, MSocSc
Tommi Härkänen, PhD
Sami Pirkola, MD, PhD
Matti Joukamaa, MD, PhD
Seppo Koskinen, MD, PhD, MSc
Jouko Lönnqvist, MD, PhD
Antti Reunanen, MD, PhD
Publication date
01-04-2008
Publisher
D. Steinkopff-Verlag
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2008
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-007-0762-y

Other articles of this Issue 3/2008

European Archives of Psychiatry and Clinical Neuroscience 3/2008 Go to the issue

Erratum

Erratum