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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2013

01-04-2013 | Retinal Disorders

Two-year outcome of photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide for polypoidal choroidal vasculopathy

Authors: Isao Nakata, Akitaka Tsujikawa, Kenji Yamashiro, Atsushi Otani, Sotaro Ooto, Yumiko Akagi-Kurashige, Naoko Ueda-Arakawa, Daisuke Iwama, Nagahisa Yoshimura

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2013

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Abstract

Purpose

To compare the 2-year results after photodynamic therapy (PDT) alone and PDT combined with intravitreal injections of bevacizumab and triamcinolone acetonide (triple therapy) for polypoidal choroidal vasculopathy (PCV).

Methods

We retrospectively reviewed the medical records of 40 consecutive patients (40 eyes) with subfoveal PCV. Of these 40 eyes, 16 were treated with PDT alone and 24 were treated with triple therapy.

Results

The change in visual acuity in the triple therapy group was significantly better than that in the PDT group (P < 0.001). At 24 months, improvement in visual acuity was seen in only two eyes (12.5 %) of the PDT group, while it was seen in ten eyes (41.7 %) of the triple therapy group. Retreatment was given to 12 eyes (75.0 %) in the PDT group and to nine eyes (37.5 %) in the triple therapy group, although the retreatment-free period was significantly longer in the triple therapy group than in the PDT group (P < 0.001). Post-treatment vitreous hemorrhage was seen in only two eyes (12.5 %), all of which were in the PDT group.

Conclusion

Compared with PDT alone, triple therapy appears to reduce the postoperative hemorrhagic complications and recurrences of PCV and to improve the 2-year visual outcomes of PCV.
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Metadata
Title
Two-year outcome of photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide for polypoidal choroidal vasculopathy
Authors
Isao Nakata
Akitaka Tsujikawa
Kenji Yamashiro
Atsushi Otani
Sotaro Ooto
Yumiko Akagi-Kurashige
Naoko Ueda-Arakawa
Daisuke Iwama
Nagahisa Yoshimura
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-012-2137-y

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