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International Orthopaedics

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01-01-2019 | Original Paper

Two-stage cementless hip revision for peri-prosthetic infection with an antibacterial hydrogel coating: results of a comparative series

Authors: Luigi Zagra, Enrico Gallazzi, Delia Romanò, Sara Scarponi, Carlo Romanò

Published in: International Orthopaedics | Issue 1/2019

Abstract

Purpose

The aim of this study was to investigate the hypothesis that a two-stage exchange procedure, performed with an antibiotic-loaded, fast-resorbable hydrogel coating, may provide better infection cure rate than a two-stage procedure without the coating, in patients affected by peri-prosthetic hip infection.

Methods

In this case-control study, 27 patients, treated with a two-stage procedure, using cementless implants coated with an antibiotic-loaded hydrogel (DAC®, “Defensive Antibacterial Coating”), were compared with 27 matched controls, treated with a two-stage cementless revision procedure, without the coating.

Results

At a mean follow-up of 2.7 (minimum 2.1–maximum 3.5) years, no evidence of infection, implant loosening, or adverse events were observed in the DAC-treated group, compared to four cases of infection recurrence in the control group.

Conclusions

Although in a relatively limited series of patients our data show that cementless two-stage hip revision, performed with an antibacterial hydrogel coating, may provide better infection control than two-stage without the coating, with reduced hospitalization time, these findings warrant further studies in the possible applications of antibacterial coating technologies to treat implant-related infections.

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Title: Two-stage cementless hip revision for peri-prosthetic infection with an antibacterial hydrogel coating: results of a comparative series
Authors: Luigi Zagra
Enrico Gallazzi
Delia Romanò
Sara Scarponi
Carlo Romanò
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: International Orthopaedics / Issue 1/2019
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-018-4206-2

At a glance: The STEP trials

Springer Medicine

Two-stage cementless hip revision for peri-prosthetic infection with an antibacterial hydrogel coating: results of a comparative series

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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