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Open Access 01-01-2019 | Note

Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Authors: Sutin Kaennakam, Kamonwan Mudsing, Kitiya Rassamee, Pongpun Siripong, Santi Tip-pyang

Published in: Journal of Natural Medicines | Issue 1/2019

Abstract

Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3–8) and anthraquinones (9–10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3–6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC₅₀ values in the range of 1.45–9.46 µM.

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Title: Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana
Authors: Sutin Kaennakam
Kamonwan Mudsing
Kitiya Rassamee
Pongpun Siripong
Santi Tip-pyang
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1240-8

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Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Abstract

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Abstract

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